HOME >> BIOLOGY >> NEWS
Cultured Neural Stem Cells Reduce Symptoms In Model Of Parkinsons Disease

For decades, researchers have imagined treating human diseases by replacing damaged cells with stem cells -- embryonic cells from which all other kinds of cells develop. While the potential benefits are enormous, such strategies have been limited by an uncertain supply of stem cells. Now, scientists have shown that neural stem cells can be multiplied and raised to maturity in the laboratory and that these cells can greatly reduce symptoms in an animal model of Parkinson's disease.

The study is the first to show that neural stem cells grown outside the body can form specific kinds of neurons -- in this case, dopamine-producing cells -- and that these neurons can survive and function normally when they are transplanted into the living brain. Dopamine is an important nerve signaling chemical, or neurotransmitter, and the loss of dopamine-producing cells in one region of the brain is responsible for the symptoms seen in Parkinson's disease. The new finding suggests that cells multiplied in culture may ultimately prove useful in treating Parkinson's and other nervous system diseases. It also provides new opportunities for studying how the brain develops that may greatly improve understanding of nervous system disorders, says Ronald McKay, Ph.D., of the National Institute of Neurological Disorders and Stroke (NINDS), senior author of the report which will appear in the August 1998 issue of Nature Neuroscience (1).

"Cells are the ultimate device for delivering substances to the brain, so this could become one of the most widely used therapies in medical research," says Dr. McKay.

Unlike the original cells of the embryo, which can form literally any kind of cell, neural stem cells are restricted to becoming nervous system cells. However, they still can develop into all the types of cells that make up the brain and spinal cord. The process in which cells that start out with unlimited potential fates develop into specific types
'"/>

Contact: Natalie Larsen
301/496-5751
NIH/National Institute of Neurological Disorders and Stroke
20-Jul-1998


Page: 1 2 3 4

Related biology news :

1. Cultured sea fans to be re-seeded in Florida keys national marine sanctuary
2. Neural stem cells take a step closer to the clinic
3. Neural biology explains ejaculation
4. Neural development in time and space
5. Neural signal that helps wire up brains movement circuit identified
6. Neural stem cells can develop into functional neurons
7. Neural stem cells move to damaged areas of brain after injury
8. Human Neural Stem Cells Advance Distant Prospect Of Reseeding Damaged Brain
9. Scientists Discover How Genes Work Together To Control Neural Development
10. Medicinal Leech May Offer Clues To Neural Regeneration
11. Cells may shoot messenger to halt protein production

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/26/2017)... , Feb. 25, 2017  Securus Technologies, ... technology solutions for public safety, investigation, corrections and ... Recidivism and Reentry. "Too often, too ... prisons and county jails are trying to tackle ... inmates and friends and family members. While significant steps ...
(Date:2/21/2017)... February 21, 2017 Der weltweite ... wachsen. Nach einem Gespräch mit mehr als 50 Vertretern aus ... zu überwinden gilt, um diese Prognose zu realisieren. ... ... Mobilisierung der finanziellen Mittel für die Biobank, die Implementierung ...
(Date:2/13/2017)... Feb. 13, 2017 Former 9/11 Commission border ... Committee, Janice Kephart of Identity Strategy Partners, ... Donald Trump,s "Executive Order: Protecting the Nation From ... 2017):  "As President Trump,s ,Travel Ban, Executive ... now essentially banned the travel ban, it is important ...
Breaking Biology News(10 mins):
(Date:3/22/2017)... ... , ... March 22, 2017...Council for Agricultural Science and Technology, Ames, Iowa. ... innovation in smart, sustainable ways. Humans depend on plants for food, feed, fiber, and ... This paper is the first in a series that connects science and technology to ...
(Date:3/22/2017)...  RXi Pharmaceuticals Corporation (NASDAQ: RXII), a clinical-stage ... unmet medical needs, today announced Alexey Eliseev ... at the 5th Annual Cancer BioPartnering & Investment ... present to and meet with thought leaders from ... as well as institutional investors. This event will ...
(Date:3/20/2017)... ... March 20, 2017 , ... ... the ability of endogenous hormones to regulate homeostasis via their cognate nuclear ... EDCs produce adverse reproductive, neurological, proliferative, and immunological disorders. EDC exposure can ...
(Date:3/20/2017)... ... March 20, 2017 , ... ... sample preparation methods in order to reduce the impact on instrumentation. ICP-MS is ... area of elemental analysis. , This presentation will discuss the pros and ...
Breaking Biology Technology:
Cached News: