HOME >> BIOLOGY >> NEWS
Cutting edge

Scientists have long toyed with the idea of putting to work a special class of biological catalysts, called ribozymes, as therapeutic agents. These molecular scissors would harness the activities of overly active genes that contribute to diseases like cancer by cutting their immediate products, messenger RNAs, into unusable pieces. The advantage of this approach, is that these molecules can be made to recognize very specific targets. This is reported in this month issue of EMBO reports.

Up until now, however, technical difficulties have hampered the development of such tools; the targets for these molecules are often folded extensively, making particular cleavage sites inaccessible to the catalyst. However, in the May 15 issue of EMBO reports, H. Kawasaki and K. Taira report on a technical breakthrough. By linking ribozymes to helicases, cellular components whose normal function is to smooth out folded RNAs to allow them to be translated into proteins, these investigators have managed to circumvent this folding difficulty. They have been able to efficiently inhibit the activities of a number of target RNAs, even at sites that are known to be inaccessible to regular ribozymes. This has further allowed them to develop a method for investigating the functions of random RNAs, creating a tool that may be invaluable in characterizing the functions of many of the previously unknown genes that have only recently been uncovered by various genome projects. Although we are not yet ready to treat any diseases using ribozymes, this study may indeed be a big step in the right direction.


'"/>

Contact: Ellen Peerenboom
ellen.peerenboom@embo.org
49-6221-8891-108
European Molecular Biology Laboratory
15-May-2002


Page: 1

Related biology news :

1. Cutting-edge cancer researchers sought for international recognition
2. Cutting back on cigarettes: when less is more
3. AChemS: Cutting edge research in taste, smell, & chemical irritation
4. Cutting-edge research to be presented at ASCPT pharmacology conference
5. Cutting the risk of coronary disease - start before birth says UK doctor
6. Story Tips: Engineering Students Pursue Cutting-Edge Research
7. Brain Building May Depend On DNA Cutting And Pasting
8. Cutting The Time And Cost Of Developing New Cures: Lord Sainsbury Launches Worlds First Biomedical Accelerator Mass Spectrometer In York
9. Flexibility In Cutting Toxic Releases Yields Dividends
10. Gene Shears In Cutting Edge Anti-Aids Trial

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/4/2019)... ... June 04, 2019 , ... Molecular Devices, ... Susan Murphy as the new President of Molecular Devices, replacing Greg Milosevich who ... company, Danaher Corporation. , Since joining Molecular Devices in a scientific engineering role, ...
(Date:6/3/2019)... ... June 03, 2019 , ... Stay on top of current hot topics ... industries. Access to all webinars is free, so be sure to register today to ... Visit http://www.xtalks.com to see our upcoming webinars: , CLINICAL TRIALS , June ...
(Date:5/31/2019)... ... 2019 , ... Join Julie Peacock, Vice President of Product ... June 19, 2019 at 1pm EDT where she will demonstrate how role-based data ... contract research organizations (CROs) can improve collaboration, auditing, document tracking and reporting. , ...
Breaking Biology News(10 mins):
(Date:5/14/2019)... ... May 13, 2019 , ... ... testing instruments for the Pharmaceutical, Biotechnology, Medical Device and Food Packaging Industries’ is ... redesigned website aims to improve LDA’s ability to communicate directly with the marketplace; ...
(Date:5/4/2019)... ... 03, 2019 , ... Diopsys Inc, the world leader in ... vision test, a new full field electroretinography (ffERG) protocol designed to detect ... Americans will have glaucoma, with black Americans having the highest prevalence rate. This ...
(Date:5/2/2019)... ... May 02, 2019 , ... ... in the greater Boston area. Gone are the days of painful hair transplant ... Robotic Hair Restoration System is the only robotic intelligent solution to offer a ...
(Date:4/16/2019)... , ... April 16, 2019 , ... ... systems, applications, and technology, today announced that Bank South Pacific (BSP), the largest ... RFP process. The bank awarded Fulcrum a contract to deliver a fingerprint-based Know ...
Breaking Biology Technology:
Cached News: