HOME >> BIOLOGY >> NEWS
DNA: A sloppier copier

Novel, Mutation-Prone DNA Replication Enzyme Identified

University researchers have resolved an enigma of more than three decades standing by definitively establishing how ultraviolet radiation causes genetic mutation in a common bacteria.

The resolution is a surprise. While radiation is the stimulus, the group found, most of the resulting mutations are self-inflicted wounds, caused by a highly error-prone emergency DNA copying system of a novel kind.

The discovery of this system, announced in a paper in the Aug. 3 issue of the Proceedings of the National Academy of Sciences, sheds light on a fundamental cell survival process. The process is highly significant in aging, cancer and species evolution. It may even offer a clue to the solution of another long-standing mystery -- why the immune system's globulin genes are so prone to error.

A research team led by Myron F. Goodman, Ph.D., of the University of Southern California, studied a complex of evanescent substances seen at sites of DNA replication in Escherichia coli bacteria exposed to ultraviolet light. The team has established that the complex is a DNA polymerase, the fifth DNA replicating enzyme to be identified in the organism.

The new enzyme, named "pol V," differs in two significant ways from pols I, II and III, which are well-known enzymes.

First, pol V is a highly inaccurate replicator of DNA. While the other three enzyme systems copy and reproduce information-carrying sequences of the chemical bases in the DNA alphabet with an error rate of fewer than one mistake per million bases, the newly discovered enzyme is about 100 times more error-prone.

Second, pol V's structure is quite distinct from the others', which are all variations on a single design first identified in 1956 by Arthur Kornberg in work for which he shared the 1959 Nobel Prize in medicine. Dr. Goodman, a professor of biological sciences in the USC College of Letters, Arts and Sciences, notes
'"/>

Contact: mankin@usc.edu
mankin@usc.edu
213-740-9344
University of Southern California
2-Aug-1999


Page: 1 2 3 4

Related biology news :

1. Nearly two-thirds of GPs are unaware that insulin resistance, a fundamental cause of type 2 diabetes, is thought to be present in 92% of people with the disease
2. Nearly identical controls of immune genes in mice and humans hint at new asthma treatment
3. Nearly half of all women 65 and older now use herbal products to feel better, but dont tell their doctors
4. Honeybees In The Wild Nearly Gone In North America
5. Impact of Earths rising atmospheric carbon dioxide found in world oceans
6. Continents played key role in collapse and regeneration of Earths early greenhouse, geologists say
7. Unexpected changes in Earths climate observed on the dark side of the moon
8. Uncovering mysteries beneath the Earths surface
9. Tourism to Earths most threatened areas surges by over 100 percent in last decade
10. Scripps research gives tiny phytoplankton a large role in Earths climate system
11. Increasing nitrogen in Earths soils may signal global changes, say U. of Colorado researchers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/31/2017)...  Spero Therapeutics, LLC, a biopharmaceutical company founded ... bacterial infections, today announced it has acquired a ... Bono Bio Ltd (PBB) to bolster its pipeline ... of Gram-negative bacteria.   The assets acquired have been ... group company. "The acquisition of these ...
(Date:1/25/2017)... The Elements of Enterprise Information Security ... of a comprehensive set of business processes and ... identities and providing a secured and documented access ... number of programs opted by enterprises to maintain ... processes and changing policies. However, there are some ...
(Date:1/21/2017)... 20, 2017 Research and Markets has announced ... report to their offering. ... The global voice recognition biometrics market to grow ... The report covers the present scenario and the growth prospects ... the market size, the report considers the revenue generated from the ...
Breaking Biology News(10 mins):
(Date:2/27/2017)... FRANCISCO , Feb. 27, 2017 Fluxion ... Spain has been appointed as a ... System. The IsoFlux system will be used in Genetracer ... relevant to lung and colon cancer, with plans to ... The laboratory is utilizing Fluxion,s IsoFlux System to isolate, ...
(Date:2/25/2017)... ... February 25, 2017 , ... The STARR ... an ongoing effort to create meaningful change by increasing communication, partnerships and goodwill ... on consumers and patients’ mental health well-being. , Both organizations are dedicated to ...
(Date:2/24/2017)... Provectus Biopharmaceuticals, Inc. (OTCQB: PVCT, ... oncology and dermatology biopharmaceutical company, today is providing ... its previously announced rights offering of up to ... stock and Series C Convertible Preferred Stock to ... As previously announced, the rights offering ...
(Date:2/24/2017)... HONG KONG, Feb. 24, 2017 China Cord Blood ... "Company"), China,s leading provider of cord blood collection, laboratory ... services, today announced its unaudited financial results for the ... 2017 ended December 31, 2016. Third Quarter ... the third quarter of fiscal 2017 increased by 18.6% ...
Breaking Biology Technology:
Cached News: