HOME >> BIOLOGY >> NEWS
DNA: A sloppier copier

Novel, Mutation-Prone DNA Replication Enzyme Identified

University researchers have resolved an enigma of more than three decades standing by definitively establishing how ultraviolet radiation causes genetic mutation in a common bacteria.

The resolution is a surprise. While radiation is the stimulus, the group found, most of the resulting mutations are self-inflicted wounds, caused by a highly error-prone emergency DNA copying system of a novel kind.

The discovery of this system, announced in a paper in the Aug. 3 issue of the Proceedings of the National Academy of Sciences, sheds light on a fundamental cell survival process. The process is highly significant in aging, cancer and species evolution. It may even offer a clue to the solution of another long-standing mystery -- why the immune system's globulin genes are so prone to error.

A research team led by Myron F. Goodman, Ph.D., of the University of Southern California, studied a complex of evanescent substances seen at sites of DNA replication in Escherichia coli bacteria exposed to ultraviolet light. The team has established that the complex is a DNA polymerase, the fifth DNA replicating enzyme to be identified in the organism.

The new enzyme, named "pol V," differs in two significant ways from pols I, II and III, which are well-known enzymes.

First, pol V is a highly inaccurate replicator of DNA. While the other three enzyme systems copy and reproduce information-carrying sequences of the chemical bases in the DNA alphabet with an error rate of fewer than one mistake per million bases, the newly discovered enzyme is about 100 times more error-prone.

Second, pol V's structure is quite distinct from the others', which are all variations on a single design first identified in 1956 by Arthur Kornberg in work for which he shared the 1959 Nobel Prize in medicine. Dr. Goodman, a professor of biological sciences in the USC College of Letters, Arts and Sciences, notes
'"/>

Contact: mankin@usc.edu
mankin@usc.edu
213-740-9344
University of Southern California
2-Aug-1999


Page: 1 2 3 4

Related biology news :

1. Nearly two-thirds of GPs are unaware that insulin resistance, a fundamental cause of type 2 diabetes, is thought to be present in 92% of people with the disease
2. Nearly identical controls of immune genes in mice and humans hint at new asthma treatment
3. Nearly half of all women 65 and older now use herbal products to feel better, but dont tell their doctors
4. Honeybees In The Wild Nearly Gone In North America
5. Impact of Earths rising atmospheric carbon dioxide found in world oceans
6. Continents played key role in collapse and regeneration of Earths early greenhouse, geologists say
7. Unexpected changes in Earths climate observed on the dark side of the moon
8. Uncovering mysteries beneath the Earths surface
9. Tourism to Earths most threatened areas surges by over 100 percent in last decade
10. Scripps research gives tiny phytoplankton a large role in Earths climate system
11. Increasing nitrogen in Earths soils may signal global changes, say U. of Colorado researchers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/28/2017)... , March 28, 2017 The ... Hardware (Camera, Monitors, Servers, Storage Devices), Software (Video Analytics, ... Region - Global Forecast to 2022", published by MarketsandMarkets, ... 2016 and is projected to reach USD 75.64 Billion ... and 2022. The base year considered for the study ...
(Date:3/24/2017)... 24, 2017 The Controller General of Immigration from ... Abdulla Algeen have received the prestigious international IAIR Award for the ... Continue Reading ... ... Controller Abdulla Algeen (small picture on the right) have received the IAIR ...
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based ... to 2022", published by MarketsandMarkets, the market is expected to be worth USD ... 2022. Continue Reading ... ... ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... and LAGUNA HILLS, Calif. , Oct. ... Cancer Research, London (ICR) and University ... SKY92, SkylineDx,s prognostic tool to risk-stratify patients with multiple myeloma ... MUK nine . The University of Leeds ... partly funded by Myeloma UK, and ICR will perform the ...
(Date:10/10/2017)... ... 2017 , ... San Diego-based team building and cooking events company, Lajollacooks4u, has ... The bold new look is part of a transformation to increase awareness, appeal to ... period. , It will also expand its service offering from its signature gourmet cooking ...
(Date:10/10/2017)... 10, 2017 International research firm Parks Associates announced ... at the TMA 2017 Annual Meeting , October 11 in ... residential home security market and how smart safety and security products impact ... Parks Associates: Smart Home ... "The residential security market has ...
(Date:10/9/2017)... DIEGO , Oct. 9, 2017  BioTech ... biological mechanism by which its ProCell stem cell ... critical limb ischemia.  The Company, demonstrated that treatment ... amount of limbs saved as compared to standard ... the molecule HGF resulted in reduction of therapeutic ...
Breaking Biology Technology:
Cached News: