HOME >> BIOLOGY >> NEWS
DNA: A sloppier copier

Novel, Mutation-Prone DNA Replication Enzyme Identified

University researchers have resolved an enigma of more than three decades standing by definitively establishing how ultraviolet radiation causes genetic mutation in a common bacteria.

The resolution is a surprise. While radiation is the stimulus, the group found, most of the resulting mutations are self-inflicted wounds, caused by a highly error-prone emergency DNA copying system of a novel kind.

The discovery of this system, announced in a paper in the Aug. 3 issue of the Proceedings of the National Academy of Sciences, sheds light on a fundamental cell survival process. The process is highly significant in aging, cancer and species evolution. It may even offer a clue to the solution of another long-standing mystery -- why the immune system's globulin genes are so prone to error.

A research team led by Myron F. Goodman, Ph.D., of the University of Southern California, studied a complex of evanescent substances seen at sites of DNA replication in Escherichia coli bacteria exposed to ultraviolet light. The team has established that the complex is a DNA polymerase, the fifth DNA replicating enzyme to be identified in the organism.

The new enzyme, named "pol V," differs in two significant ways from pols I, II and III, which are well-known enzymes.

First, pol V is a highly inaccurate replicator of DNA. While the other three enzyme systems copy and reproduce information-carrying sequences of the chemical bases in the DNA alphabet with an error rate of fewer than one mistake per million bases, the newly discovered enzyme is about 100 times more error-prone.

Second, pol V's structure is quite distinct from the others', which are all variations on a single design first identified in 1956 by Arthur Kornberg in work for which he shared the 1959 Nobel Prize in medicine. Dr. Goodman, a professor of biological sciences in the USC College of Letters, Arts and Sciences, notes
'"/>

Contact: mankin@usc.edu
mankin@usc.edu
213-740-9344
University of Southern California
2-Aug-1999


Page: 1 2 3 4

Related biology news :

1. Nearly two-thirds of GPs are unaware that insulin resistance, a fundamental cause of type 2 diabetes, is thought to be present in 92% of people with the disease
2. Nearly identical controls of immune genes in mice and humans hint at new asthma treatment
3. Nearly half of all women 65 and older now use herbal products to feel better, but dont tell their doctors
4. Honeybees In The Wild Nearly Gone In North America
5. Impact of Earths rising atmospheric carbon dioxide found in world oceans
6. Continents played key role in collapse and regeneration of Earths early greenhouse, geologists say
7. Unexpected changes in Earths climate observed on the dark side of the moon
8. Uncovering mysteries beneath the Earths surface
9. Tourism to Earths most threatened areas surges by over 100 percent in last decade
10. Scripps research gives tiny phytoplankton a large role in Earths climate system
11. Increasing nitrogen in Earths soils may signal global changes, say U. of Colorado researchers

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: DNA sloppier copier

(Date:10/22/2014)... Oct. 21, 2014 Aware, Inc. (NASDAQ: ... today reported financial results for its third quarter ended September ... 2014 was $6.0 million, an increase of 40% compared to ... in the third quarter of 2014 was $4.1 million compared ... operating income in the current three month period was primarily ...
(Date:10/18/2014)... of patients with undiagnosed, suspected genetic conditions, a certain ... higher molecular diagnostic yield than traditional molecular diagnostic methods, ... The study is being released to coincide with the ... sequencing, which sequences the protein­coding region of the genome ... in a cell or organism), has been rapidly applied ...
(Date:10/17/2014)... German . ... When treating overdoses, doctors are often limited to supportive therapy ... is a combination of drugs involved. So what can be ... grandmother,s pills? ETH professor Jean-Christophe Leroux from the Institute of ... to this question. "The task was to develop an agent ...
Breaking Biology News(10 mins):Aware, Inc. Reports Third Quarter 2014 Financial Results 2Aware, Inc. Reports Third Quarter 2014 Financial Results 3Aware, Inc. Reports Third Quarter 2014 Financial Results 4Aware, Inc. Reports Third Quarter 2014 Financial Results 5Aware, Inc. Reports Third Quarter 2014 Financial Results 6Aware, Inc. Reports Third Quarter 2014 Financial Results 7Study examines type of exome sequencing and molecular diagnostic yield 2Study examines type of exome sequencing and molecular diagnostic yield 3Emergency aid for overdoses 2Emergency aid for overdoses 3
(Date:10/25/2014)... October 24, 2014 SonaCare Medical, ... ultrasound (HIFU) technology, announced that its Board of ... Chief Executive Officer, President and member of the ... Carol will take-on expanded responsibilities within the company, ... well as overseeing commercialization, manufacturing and finance. ...
(Date:10/25/2014)... ROCKVILLE, Md. , Oct. 24, 2014  RegeneRx Biopharmaceuticals, ... on data presented at the Fourth International Symposium on ... , Italy.  "When thymosin beta ... was injected into the peritoneal cavity in a rodent ... vessels and throughout the brain parenchyma (the functional tissue ...
(Date:10/22/2014)... -- Research and Markets has announced ... Market (Product types, Application, Technology, End User and ... Demand, Insights, Analysis, Research, Report, Opportunities, Segmentation and ... offering. This new report titled, ... and Geography) Global Size, Industry Analysis, Trends, Opportunities, ...
(Date:10/22/2014)... Involution Studios , a healthcare software ... infographic, Understanding Ebola . The goal of ... to follow informative tool for anyone wanting to know ... prevention. , "As the news has spread in all ... represents not only a healthcare crisis with global impact, ...
Breaking Biology Technology:SonaCare Medical Board of Directors Appoints Dr. Mark Carol as CEO and President 2SonaCare Medical Board of Directors Appoints Dr. Mark Carol as CEO and President 3Researchers Report Thymosin Beta 4 Crosses Blood-Brain Barrier In Animal Stroke Model 2Global DNA Diagnostics Market (Product types, Application, Technology, End User and Geography) - Forecast to 2020 2Global DNA Diagnostics Market (Product types, Application, Technology, End User and Geography) - Forecast to 2020 3Involution Studios' Ebola Infographic Provides Key Disease Information and Statistics at a Glance 2
Cached News: