HOME >> BIOLOGY >> NEWS
DNA arrays give clues to better vaccines

"We are in the midst of a revolution in the way researchers study infectious diseaseinstead of depending on culture dishes as the only way to observe the behavior of pathogens, scientists are able to eavesdrop on the cross talk between invading microbes and the immune cells of our body," says Richard Young of the Whitehead Institute of Biomedical Research. Youngs lab has done this using DNA microarrays to explore the responses of human macrophages to a variety of bacteria, and as a result, has found clues to making safer, more potent vaccines.

Macrophages, immune cells that are part of the first line of defense, recognize and engulf microbes in a vigilant effort to keep the body healthy. The researchers found that macrophages respond to a broad range of bacteria by sending off an alarm to the rest of the immune system and transforming into a cell primed to mount an immune response.

Further study revealed that the macrophage didnt have to "see" the whole bacteria to send off its alarm signal, but the presence of specific bacterial components, such as proteins and sugars, induced activation. "These findings will help researchers design therapeutics that will stimulate the immune system in a targeted manner, perhaps with fewer side effects," says Young, lead author on the study, which will appear in the February 5 issue of Proceedings of the National Academy of Sciences.

"The interplay between a persons immune mechanisms and a microbes attempts to circumvent these defenses represents a complex relationship. DNA arrays help researchers dissect this struggle by measuring the activity of many genes in the immune cells as they respond to pathogens. As a result, researchers gain invaluable information about the strengths and vulnerabilities of the microbes and our own immune system during an infection," explains Gerard Nau, a first co-author on the study and a researcher in the Young lab. Ann Schlesinger, postdoctoral fellow in the Young lab, and Jo
'"/>

Contact: Nadia Halim
halim@wi.mit.edu
617-258-9183
Whitehead Institute for Biomedical Research
29-Jan-2002


Page: 1 2 3

Related biology news :

1. No longer just for biology, RNA can now be built into 3-D arrays
2. New glycan arrays discover autoimmunogenic activities of SARS-CoV: concern over monkey vaccine
3. Microarrays, key genome expression trackers, work better when probes are sequence-verified
4. Library on a Slide: Whole genome microarrays for comparative genomics
5. DNA arrays diagnose, predict survival for Sezary syndrome cancer patients
6. Stanfords new antigen microarrays open window to better disease screening
7. Scientists develop protein nanoarrays for biological detection
8. DNA arrays decipher genomes master switches
9. University of Alberta researcher looks for clues to mysterious disease
10. Broken arms and collateral damage: clues to predator-driven evolution
11. Researchers find clues about how antibodies specialize

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/18/2020)... , ... July 17, 2020 , ... Commercial launch readiness ... pharma’s ability to discover a COVID cure or vaccine, the global economic downturn will ... price pressure is not going away and capturing full value from every product launch ...
(Date:7/2/2020)... ... July 01, 2020 , ... ... phase 1a findings of Neihulizumab, a biologic for the treatment of steroid-refractory acute ... Led by hemato-oncologist Dr. Paul J Martin of the Fred Hutchinson Cancer Research ...
(Date:6/28/2020)... BASEL, Switzerland (PRWEB) , ... ... ... leading provider of enterprise software solutions for biopharmaceutical R&D, today announced that ... oncology company developing innovative, full-length multispecific antibodies (Multiclonics®), to support their translational ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... (PRWEB) , ... August 12, 2020 , ... ... Inc. (EMMA International), a global leader in FDA compliance consulting has been ... nation’s fastest-growing private companies. The list represents a unique look at the most ...
(Date:8/3/2020)... PHILADELPHIA (PRWEB) , ... August 03, 2020 , ... ... data collection, today announced Jim Corrigan, President and CEO has been named one ... a broad cross-section of industry sectors, PharmaVoice 100 honorees are selected based on ...
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is now ... With 50 million stem cells total, patients may choose which extremities they would like ... arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is obtained ...
(Date:7/31/2020)... ... 29, 2020 , ... Diversified Technologies, Inc. has introduced a ... to drive Klystrons, TWTs, IOTs, and magnetrons. , DTI Radar Transmitter Systems ... a push-pull configuration; yielding fast fall time for a capacitive load. These all ...
Breaking Biology Technology:
Cached News: