HOME >> BIOLOGY >> NEWS
DNA-based vaccine triples survival for dogs with melanoma

NEW YORK April 8, 2003 The options for treating advanced melanoma are limited - regardless of whether the patient is a dog or a human. Because this deadly cancer is virtually resistant to chemotherapy and radiation in its late stages, new approaches are being investigated including vaccines that harness the immune system. For nine dogs that naturally developed canine malignant melanoma, treatment with a new DNA-based vaccine more than tripled their median survival from an expected 90 days to an average of 389 days.

The results of this collaboration between the dogs' veterinarians at The Animal Medical Center (AMC) and researchers at Memorial Sloan-Kettering Cancer Center where the DNA-based vaccine had undergone pre-clinical testing are reported in the April issue of the Clinical Cancer Research. The vaccine continues to be studied at AMC. A parallel clinical trial began last fall at MSKCC for people with high risk of melanoma recurrence.

"Most medicines that we use to treat animals are the same as those given to humans," explained Philip J. Bergman DVM, MS, PhD, Head of the Donaldson-Atwood Cancer Clinic and the Flaherty Comparative Oncology Laboratory at The Animal Medical Center and the study's first author. "This vaccine was first tested in the laboratory at MSKCC and then given to dogs with melanoma after receiving approval from the United States Department of Agriculture and the AMC's own Institutional Review Board. We felt it was useful to see if immunotherapy might help these very sick dogs with advanced melanoma since the response rates for standard chemotherapy were extremely poor with no evidence of improved survival."

Canine malignant melanoma (CMM) is the most common oral cancer in dogs and accounts for one out of twenty cancer diagnoses. It is highly aggressive, occurring spontaneously in the mouth, nail bed and foot pad. CMM is most successfully treated in its early stage by surgery. However, the prognosis is not good if ther
'"/>

Contact: Joanne Nicholas
media@mskcc.org
212-639-3573
Memorial Sloan-Kettering Cancer Center
9-Apr-2003


Page: 1 2

Related biology news :

1. DNA-based flu vaccine raises protective immunity
2. Discussion May 24 on recommendations for animal studies on DNA-based therapies, herbs, emissions from cellular phones
3. Cancer vaccine based on pathogenic listeria bacteria shows promise targeting metastases
4. Pneumococcal vaccine reduces ear infections, pneumonia, new study shows
5. UC Irvine scientists to develop vaccine to combat bioterrorism threat from deadly bacteria
6. First clinical study of new pediatric croup vaccine shows safety, tolerability in adults
7. Protective gene may enhance vaccine responses
8. Protein vaccine fully protects mice from lethal aerosol challenge with ricin toxin
9. New glycan arrays discover autoimmunogenic activities of SARS-CoV: concern over monkey vaccine
10. Growing new breed of vaccine-producing plants to fight human diseases worldwide
11. Childrens Hospital Boston receives more than $10 million to help make smallpox vaccine safer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... Research and Markets has announced the addition of the "Global ... ... at a CAGR of 30.37% during the period 2017-2021. ... based on an in-depth market analysis with inputs from industry experts. ... the coming years. The report also includes a discussion of the ...
(Date:4/11/2017)... 2017 NXT-ID, Inc. (NASDAQ:   NXTD ... the appointment of independent Directors Mr. Robin D. Richards ... of Directors, furthering the company,s corporate governance and expertise. ... Gino Pereira , Chief ... to their guidance and benefiting from their considerable expertise as ...
(Date:4/5/2017)... , April 5, 2017  The Allen Institute ... Allen Cell Explorer: a one-of-a-kind portal and dynamic digital ... 3D imaging data, the first application of deep learning ... human stem cell lines and a growing suite of ... platform for these and future publicly available resources created ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... The Blavatnik ... Winners and six Finalists of the 2017 Blavatnik Regional Awards for Young Scientists. ... Foundation and administered by the New York Academy of Sciences to honor the ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... partners with the pharmaceutical and biotechnology industries to improve patient outcomes and quality ... Several trends in analytical testing are being attributed to new regulatory requirements for ...
(Date:10/11/2017)... ... ... Personal eye wash is a basic first aid supply for any work environment, but most ... you rinse first if a dangerous substance enters both eyes? It’s one less decision, and ... unique dual eye piece. , “Whether its dirt and debris, or an acid or alkali, ...
(Date:10/11/2017)... ROTTERDAM, the Netherlands and LAGUNA HILLS, ... that The Institute of Cancer Research, London ... will use MMprofiler™ with SKY92, SkylineDx,s prognostic tool to risk-stratify ... high-risk trial known as MUK nine . The University ... this trial, which is partly funded by Myeloma UK, and ...
Breaking Biology Technology:
Cached News: