HOME >> BIOLOGY >> NEWS
DNA-based vaccine triples survival for dogs with melanoma

NEW YORK April 8, 2003 The options for treating advanced melanoma are limited - regardless of whether the patient is a dog or a human. Because this deadly cancer is virtually resistant to chemotherapy and radiation in its late stages, new approaches are being investigated including vaccines that harness the immune system. For nine dogs that naturally developed canine malignant melanoma, treatment with a new DNA-based vaccine more than tripled their median survival from an expected 90 days to an average of 389 days.

The results of this collaboration between the dogs' veterinarians at The Animal Medical Center (AMC) and researchers at Memorial Sloan-Kettering Cancer Center where the DNA-based vaccine had undergone pre-clinical testing are reported in the April issue of the Clinical Cancer Research. The vaccine continues to be studied at AMC. A parallel clinical trial began last fall at MSKCC for people with high risk of melanoma recurrence.

"Most medicines that we use to treat animals are the same as those given to humans," explained Philip J. Bergman DVM, MS, PhD, Head of the Donaldson-Atwood Cancer Clinic and the Flaherty Comparative Oncology Laboratory at The Animal Medical Center and the study's first author. "This vaccine was first tested in the laboratory at MSKCC and then given to dogs with melanoma after receiving approval from the United States Department of Agriculture and the AMC's own Institutional Review Board. We felt it was useful to see if immunotherapy might help these very sick dogs with advanced melanoma since the response rates for standard chemotherapy were extremely poor with no evidence of improved survival."

Canine malignant melanoma (CMM) is the most common oral cancer in dogs and accounts for one out of twenty cancer diagnoses. It is highly aggressive, occurring spontaneously in the mouth, nail bed and foot pad. CMM is most successfully treated in its early stage by surgery. However, the prognosis is not good if ther
'"/>

Contact: Joanne Nicholas
media@mskcc.org
212-639-3573
Memorial Sloan-Kettering Cancer Center
9-Apr-2003


Page: 1 2

Related biology news :

1. DNA-based flu vaccine raises protective immunity
2. Discussion May 24 on recommendations for animal studies on DNA-based therapies, herbs, emissions from cellular phones
3. Cancer vaccine based on pathogenic listeria bacteria shows promise targeting metastases
4. Pneumococcal vaccine reduces ear infections, pneumonia, new study shows
5. UC Irvine scientists to develop vaccine to combat bioterrorism threat from deadly bacteria
6. First clinical study of new pediatric croup vaccine shows safety, tolerability in adults
7. Protective gene may enhance vaccine responses
8. Protein vaccine fully protects mice from lethal aerosol challenge with ricin toxin
9. New glycan arrays discover autoimmunogenic activities of SARS-CoV: concern over monkey vaccine
10. Growing new breed of vaccine-producing plants to fight human diseases worldwide
11. Childrens Hospital Boston receives more than $10 million to help make smallpox vaccine safer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/31/2017)... , Jan. 31, 2017  Spero Therapeutics, LLC, ... for the treatment of bacterial infections, today announced ... antibacterial candidates from Pro Bono Bio Ltd (PBB) ... of multi-drug resistant forms of Gram-negative bacteria.   The ... Infectives Ltd, a PBB group company. ...
(Date:1/25/2017)... Jan. 25, 2017 The Elements of Enterprise ... lifecycle is comprised of a comprehensive set of ... of maintaining digital identities and providing a secured ... There are significant number of programs opted by ... time by optimizing processes and changing policies. However, ...
(Date:1/21/2017)... Research and Markets has announced the addition of the ... ... voice recognition biometrics market to grow at a CAGR of 19.36% ... present scenario and the growth prospects of the global voice recognition ... considers the revenue generated from the sales of voice recognition biometrics ...
Breaking Biology News(10 mins):
(Date:2/27/2017)... , ... February 27, 2017 , ... The Catalyst ... a few in the Midwest offering premix services and private label organic services. , ... laying hens, according Jos Zamzow, chief operating officer of Dynamite Marketing, which owns the ...
(Date:2/24/2017)... ... February 24, 2017 , ... ... be safely completed in an ambulatory surgery center (ASC) with satisfactory clinical and ... previous two-year TDR studies. , Jake Lubinski, president of AxioMed, commented on ...
(Date:2/24/2017)... Tenn. , Feb. 24, 2017 ... ("Provectus" or the "Company"), a clinical-stage oncology and ... regarding the deadline to participate in its previously ... units, consisting of shares of common stock and ... and holders of listed warrants. ...
(Date:2/24/2017)... 24, 2017  Driven by consumers, preference towards ... the fastest growing categories, finds the recently published ... Personal Care: Multi-regional Market Analysis and Opportunities ... firm Kline. "Biotechnology actives are derived ... more effective for skin and hair care applications," ...
Breaking Biology Technology:
Cached News: