HOME >> BIOLOGY >> NEWS
DNA lends scientists a hand, revealing new chemical reactions

CAMBRIDGE, Mass. - Scientists have developed a powerful way of mining the chemical universe for new reactions by piggybacking collections of different small organic molecules onto short strands of DNA, which then gives the reactants the opportunity to react by zipping together. Their work draws upon an innovative technique, known as "DNA-templated synthesis," that uses DNA to code not for RNA or proteins but instead for synthetic molecules.

The researchers, led by Harvard University chemist David R. Liu, report this week in the journal Nature that their system for reaction discovery, driven by DNA-templated synthesis, is so efficient that a single researcher can evaluate thousands of potential chemical reactions in a two-day experiment.

"A conventional approach to reaction discovery, in which different reaction conditions are examined for their ability to transform one type of substrates into one type of product, may well be the best approach for trying to achieve a specific transformation," says Liu, an associate professor of chemistry and chemical biology in Harvard's Faculty of Arts and Sciences. "But no one knows what fraction of 'reactivity space' has been mined thus far, or even what this space looks like. We were therefore intrigued by a different approach to reaction discovery that does not focus on any specific combination of substrates but instead can simultaneously examine many combinations."

DNA-templated synthesis, pioneered in Liu's group, taps the unique assembly power of nucleic acids to address fundamental challenges in chemistry. Organic molecules are attached to, and "encoded" by, single strands of approximately a dozen DNA bases; when two strands with complementary sequences spontaneously stick together, their associated organic molecules can undergo a chemical reaction to generate a product.

Because the resulting synthetic compounds are linked to DNA, techniques long used to screen and amplify the genetic mainstay
'"/>

Contact: Steve Bradt
steve_bradt@harvard.edu
617-496-8070
Harvard University
29-Sep-2004


Page: 1 2 3

Related biology news :

1. NIST genetics research lends a hand in World Trade Center IDs
2. Conference at UH opens doors for new scientists, engineers
3. Wisconsin scientists develop quick botox test
4. UCI scientists successfully target key HIV protein; breakthrough may lead to new drug therapies
5. Alaska scientists find Arctic tundra yields surprising carbon loss
6. UAF scientists discover new marine habitat in Alaska
7. Information system to help scientists analyze mechanisms of social behavior
8. Zoonotic diseases - European scientists unite to fight diseases
9. Israeli scientists reveal the plan of a key cellular machine
10. Study by Israeli scientists provides insight on DNA code
11. Computer scientists at UH developing nurturing computers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/30/2019)... SANTA BARBARA, Calif. (PRWEB) , ... September 30, ... ... global technology consulting firm focused on increasing the capacity of life science organizations ... BoxWorks 2019 in San Francisco, CA on October 4th. , What: Just 30 ...
(Date:9/30/2019)... Md. (PRWEB) , ... September ... ... biotechnology market disrupter and leading supplier of innovative human mesenchymal stem/stromal cell ... for novel product formulations related to “Ready-to-Print” (RTP) cellular product formats (patent ...
(Date:9/25/2019)... AUSTIN, Texas (PRWEB) , ... September 25, 2019 ... ... Implant Center in Austin, TX, have placed over 20,000 dental implants for a ... and the highly technical zygomatic and pterygoid dental implants. Dental implants ...
Breaking Biology News(10 mins):
(Date:9/22/2019)... ... September 20, 2019 , ... ... Neurotrophic Factor (BDNF) testing in serum . BDNF plays a vital role in ... growth and differentiation of new neurons in the brain involved in learning, memory, ...
(Date:9/17/2019)... ... ... Jennifer Hermansky and Fang Xie, Ph.D. , attorneys from ... Rising Stars. Hermansky and Xie, named an Immigration Rising Star and a Life Sciences ... areas. The list highlights attorneys “whose legal accomplishments transcend their age,” according to Law360. ...
(Date:9/11/2019)... OF PRUSSIA, Pa. (PRWEB) , ... September 09, ... ... complex problems for life sciences companies and government agencies, announced that its president ... an invitation-only group of successful business leaders. , The Forbes Council accepted Gallivan ...
(Date:9/9/2019)... ... 09, 2019 , ... Visikol CEO Dr. Michael Johnson recently gave a ... to characterize 3D cell culture models. The inherent problem of characterizing 3D cell culture ... to image through and therefore traditional wide-field or even confocal microscopy only tells you ...
Breaking Biology Technology:
Cached News: