HOME >> BIOLOGY >> NEWS
DNA lends scientists a hand, revealing new chemical reactions

can be applied. In the current work, the scientists coupled DNA-templated synthesis with in vitro selection and DNA microarray analysis to scan for pairs of reactants that are able to undergo chemical reaction under a chosen set of reaction conditions.

Liu's team first applied DNA-templated synthesis to the creation of new synthetic molecules; now, shifting their focus a bit, they're using the technique to reveal as-yet undiscovered chemical reactions. DNA's inherent sequence selectivity - binding only to other strands with a complementary sequence - means that DNA-templated synthesis can be used to evaluate hundreds of potential chemical reactions simultaneously, in a single solution.

"We had assumed that DNA-templated synthesis might make possible rapid discovery of potentially useful reactions and were encouraged to find, early on, an unexpected reaction that efficiently coupled two simple hydrocarbons, a terminal alkyne and a terminal alkene, to form a useful and more complex group called a trans-enone," Liu says. "We've also been excited by the fact that this reaction not only works in the DNA-templated format in which it was discovered, but also in a conventional flask-based chemistry format."

Chemical synthesis occurs very differently in laboratories and in cells. Chemists typically work with molecules that react to form products when they randomly collide at high concentrations. By contrast, biomolecules are found within cells at concentrations that are often a million times lower than the concentrations of molecules in laboratory reactors. In nature, the reactions between these highly dilute molecules are directed by enzymes that selectively bring certain biological reactants together. Liu and his colleagues use DNA as a similar type of intermediary to bring together synthetic small molecules that are otherwise too dilute to react, allowing minute quantities of sparse molecules to behave as denser mixtures when assembled together by
'"/>

Contact: Steve Bradt
steve_bradt@harvard.edu
617-496-8070
Harvard University
29-Sep-2004


Page: 1 2 3

Related biology news :

1. NIST genetics research lends a hand in World Trade Center IDs
2. Conference at UH opens doors for new scientists, engineers
3. Wisconsin scientists develop quick botox test
4. UCI scientists successfully target key HIV protein; breakthrough may lead to new drug therapies
5. Alaska scientists find Arctic tundra yields surprising carbon loss
6. UAF scientists discover new marine habitat in Alaska
7. Information system to help scientists analyze mechanisms of social behavior
8. Zoonotic diseases - European scientists unite to fight diseases
9. Israeli scientists reveal the plan of a key cellular machine
10. Study by Israeli scientists provides insight on DNA code
11. Computer scientists at UH developing nurturing computers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/31/2019)... ... 2019 , ... FileWave, the multi-platform endpoint management solution for ... version 13.1. The new version extends FileWave’s mobile device management features on the ... functionality. Version 13.1 builds on FileWave’s version 13 that was released in early ...
(Date:5/26/2019)... ... May 24, 2019 , ... Zolgensma (Novartis, AveXis), an AAV-delivered ... approved for clinical use in the United States by the Food and Drug Administration ... approved to treat inherited genetic disorders in the United States and the second-ever approved ...
(Date:5/22/2019)... ... May 22, 2019 , ... Leak Detection Associates (LDA), the ... the Pharmaceutical, Biotechnology, Medical Device and Food Packaging Industries’ is excited to announce ... Ltd has been signed. The agreement will grant exclusive rights for IPP ...
Breaking Biology News(10 mins):
(Date:5/14/2019)... LA JOLLA, Calif. (PRWEB) , ... May 14, 2019 , ... ... announces an office expansion, effectively doubling its space from 2,500 to 5,000 square feet. ... SneakPeek Early Gender DNA tests ,” says Gateway Genomics CEO, Chris Jacob. “The ...
(Date:5/7/2019)... , ... May 06, 2019 , ... ... resource for the growing number of repositories being asked to store cellular products ... to the team of contributors who are world leaders, who have shared their ...
(Date:5/4/2019)... ... May 03, 2019 , ... Diopsys ... Diopsys® ffERG/Photopic Negative Response vision test, a new full field electroretinography ... is estimated that 6.3 million Americans will have glaucoma, with black Americans having ...
(Date:5/2/2019)... (PRWEB) , ... April 30, 2019 , ... The centuries ... industrial scale macro breweries to local craft breweries, and even home brewing clubs scattered ... complex chemical and biological processes, that when mastered can produce a superb product. Students ...
Breaking Biology Technology:
Cached News: