HOME >> BIOLOGY >> NEWS
DNA transcription is tuned to specific cells

September 14, 2001 -- Researchers have found a new example of how the machinery that controls the transcription of DNA to messenger RNA (mRNA) is tailored to specific cells or genes.

In studies in mice, the researchers discovered that TAFII105, a key component of the transcription machinery, is specific to egg-forming cells in ovaries. The finding emphasizes a newly emerging theme in molecular biology -- that DNA transcription is not standardized throughout cells but is instead adapted to control cell-specific gene expression. The scientists believe that future research is likely to reveal other cell-specific transcription components that ensure that genes are expressed in a customized way according to the needs of each cell.

The finding that TAFII105 is specifically involved in controlling genes for egg formation also hints that some inherited forms of sterility in women may be due to mutations in the TAFII105 gene, said the scientists.

In an article published in the September 14, 2001, issue of the journal Science, Howard Hughes Medical Institute investigator Robert Tjian and colleagues Richard N. Freiman, Shane R. Albright, Shuang Zheng, William C. Sha and Robert E. Hammer detailed how they traced the transcriptional role of TAFII105 to granulosa cells in the ovaries of mice. Granulosa cells surround the developing egg, called the oocyte, and foster its development.

The scientists also used DNA microarrays to explore which genes were switched off in knockout mice that lacked a functional copy of the TAFII105 gene. The TAFII105 protein is one of a family of TAF proteins that are subunits of a large complex called the transcription factor TFIID.

"When TFIID and all its associated factors were discovered ten years ago, we found it in every cell we looked at," said Tjian, who is at the University of California at Berkeley. "We thought it would be invariant from cell to cell, since it was so fundamental to the cells in transcri
'"/>

Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
13-Sep-2001


Page: 1 2 3

Related biology news :

1. Targeting transcription: New insights into turning genes on
2. UT Southwestern scientists prove certain proteins play unexpected roles in genetic transcription
3. Tidying up transcription factors
4. Post-transcriptional regulation of COX2 in tumor cells
5. Novel means for stopping transcription found, Hopkins scientists report
6. Discovery will change the way researchers look at DNA transcription, scientists say
7. Welch honors Kornberg for insights into DNA transcription
8. Different levels of transcription factor coax immune cell progenitors down different developmental pathways
9. 3-D structure of human transcription factor proteins revealed
10. Sequence of human chromosome 7 is fine-tuned and finished
11. Veterans with Gulf War syndrome have damage in specific, primitive portion of nervous system

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: DNA transcription tuned specific cells

(Date:11/15/2014)...  While we may still be a few years away ... Trek" to gain instant access to all that ailed his ... and tablets for monitoring and measuring our health are cropping ... seem a tad Orwellian to some, but a new survey ... technological opportunities into their healthcare regime. These are ...
(Date:11/11/2014)... -- Forensicon, Inc., a Chicago -based digital ... promotion of Yaniv Schiff from Senior Computer ... new role as Director, he will lead company efforts ... and provide leadership within the company,s digital forensics practice ... Schiff joined Forensicon in 2006 and ...
(Date:11/7/2014)... led by Dr. Debra Auguste, associate professor, biomedical ... The City College of New York, have identified ... for one of the most aggressive forms of ... have a high mortality rate owing to aggressive ... therapeutic options. However, Professor Auguste,s team, discovered the ...
Breaking Biology News(10 mins):Americans May Be Ready for a Brave New World of Healthcare 2Americans May Be Ready for a Brave New World of Healthcare 3Americans May Be Ready for a Brave New World of Healthcare 4Yaniv Schiff Promoted to Director of Digital Forensics at Forensicon, Inc. 2
(Date:11/22/2014)... 2014  The element of surprise has been a ... strike without warning. Until now, epidemiologists had nothing to ... outbreak, resulting in suboptimal responses to both the H1N1 ... Photo - http://photos.prnewswire.com/prnh/20141121/160242 ... because virus gene structural changes have been found that ...
(Date:11/21/2014)... England , Nov. 21, 2014   TRU-D SmartUVC ... will feature their superbug-killing UVC automated disinfection robot, TRU-D SmartUVC, ... this week from Nov. 23 to 26 at Stand 23. ... is the United Kingdom,s largest infection-related ... infection prevention societies to one of the leading events of ...
(Date:11/21/2014)... (PRWEB) November 20, 2014 Author Matthew ... Walk to the Other Side” published as a ... Finalist in the “Fiction: Short Story” category of the ... Keen, President and CEO of USA Book News, said ... and independent publishers, including Simon & Schuster, Penguin, John ...
(Date:11/21/2014)... 20, 2014 The November 2014 issue ... an open access journal featuring the following articles:, ... to preserve photoresponsiveness in the retina , ... situ hybridization using chromogenic substrates in zebrafish , ... and protein electrophoresis , Nuclear LC3-positive puncta ...
Breaking Biology Technology:Viruses' Advantage of Surprise is Lost 2TRU-D SmartUVC to Showcase Superbug-Killing Robot at FIS 2014 2TRU-D SmartUVC to Showcase Superbug-Killing Robot at FIS 2014 3Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 2Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 3Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 4BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 2BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 3
Cached News: