DNA vaccination places tumors in double jeopardy

The ER resident chaperone protein calreticulin plays a surprising variety of roles in cell regulation, some of which make it particularly appealing for antitumor vaccination. First, this protein can be cleaved in vivo to form the potent antiangiostatic factor vasostatin. In addition, when expressed in antigen presenting cells, calreticulin interacts with the peptide processing machinery to facilitate loading of associated peptides with the Class I MHC complex. Building on recent evidence that presentation of tumor-associated peptides through calreticulin can promote tumoricidal immune responses, Cheng et al. have engineered a fusion gene encoding a known viral tumor antigen, linked directly to the chaperone. They report here that mice exposed subdermally to this DNA construct enjoy seemingly complete resistance to tumor cells that express the viral antigen. Conversely, a simple mixture of the viral sequence and the calreticulin sequence has minimal effect, suggesting that calreticulin-mediated immune antigen presentation is crucial. Mice that are treated with calreticulin DNA but that lack CD8 T cells are susceptible to tumor growth, but even they appear to benefit somewhat from the effects of vasostatin, since their tumors show significantly less vascular development. It remains to be seen if this form of combined antiangiogenesis and antitumor immunity can be applied more generally by fusing calreticulin to other tumor antigens.


Contact: John Ashkenas
Journal of Clinical Investigation

Page: 1

Related biology news :

1. Smallpox vaccination grinds to halt
2. OHSU researchers publish final results of groundbreaking smallpox vaccination study
3. Measles on the rise as vaccinations fall in the UK, Science study reports
4. Rabies vaccinations could help save Ethiopian wolf
5. Study examines the potential risks of smallpox vaccination
6. Association found between anthrax vaccination, medication and health problems of Gulf War veterans
7. Dendritic cell-based vaccination to prevent opportunistic fungal infections
8. Chickens succumbing to virus formerly avoided by vaccination
9. Clemson researcher places hope on pushy photons
10. UF study: Barren Siberia, of all places, may be original home to animal life
11. UC San Diego places in top tier of institutions awarded 2004 Sloan Research Fellowships

Post Your Comments:

(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: