HOME >> BIOLOGY >> NEWS
Dance of the molecules

Until now, scientists studying the workings of ultra-microscopic forms have had to rely on the scientific equivalents of still photos, something like trying to fathom driving by looking at a photograph of a car. Now, Prof. Irit Sagi and her team of the Structural Biology Department are using new and innovative methods developed at the Weizmann Institute to see real-time "video clips" of enzyme molecules at work. The resolution of these animated clips is so fine that the scientists are able to see the movements of individual atoms within the molecule.

The challenge facing the Weizmann team was to capture, step-by-step, the complex process -- the whole of which takes place in a tiny fraction of a second -- that an enzyme molecule goes through as it performs its work. Their pioneering method was published in Nature Structural Biology. It was hailed as the first of its kind, and a potentially important tool for biophysicists.

To obtain the "live action" footage, Sagi and her team use a technique akin to stop-action photography, but on an infinitely smaller scale. They literally freeze the process at certain stages, using advanced methods of chemical analysis to determine the exact molecular layout at each stage. The most difficult part, says Sagi, was figuring out the correct time frames that would allow them to see each phase of enzyme activity clearly. She compares it to attempting to capture on film the swirling of syrup being mixed into cake batter one has to gauge at what points individual stages of the process will be most visible.

Building an animated sequence from individual frames, the scientists are granted a rare peek into the intricate dance of life on the molecular level. "This method," says Sagi, "represents more than a major breakthrough in the techniques used to understand enzyme activity. It changes the whole paradigm of drug formulation. Now we can precisely identify which parts of the molecule are the active regions (th
'"/>

Contact: Alex Smith
Alex_smith@margeotes.com
212-460-0563
American Committee for the Weizmann Institute of Science
5-Jan-2004


Page: 1 2

Related biology news :

1. Tiny molecules have big potential as cancer drugs, Stanford researcher believes
2. Synthesized molecules studied as weapon to stop cell division in cancer cells
3. Scientists reinvent DNA as template to produce organic molecules
4. Sweet success in targeting sugar molecules to cells in living animals
5. UC Riverside researcher takes snapshots of the movement of molecules in a billionth of a second
6. Scientists pinpoint molecules that generate synapses
7. Two molecules work together to aid transport of immune cells, UT Southwestern researchers find
8. Controlling biomolecules with magnetic tweezers
9. Water molecules clump more loosely than previously thought
10. Creating polymers that act like biomolecules
11. A new way to see DNA (and other tiny molecules)

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/9/2019)... ... March 08, 2019 , ... On ... announce a new initiative focused on women in the field. The Women ... that seeks to celebrate and empower emerging female leaders in the cancer immunotherapy ...
(Date:3/1/2019)... AUCKLAND, New Zealand (PRWEB) , ... March 01, 2019 , ... ... Geneious Prime to provide an easy alternative to Vector NTI. , Geneious ... metadata, structure and lineage information from Vector NTI, so that files will be organised ...
(Date:2/26/2019)... ... February 26, 2019 , ... Ms. ... position as Account Manager, Ms. Baptiste demonstrated her ability to advocate for the ... Baptiste was responsible for partnering with both the Strategic Development team and the ...
Breaking Biology News(10 mins):
(Date:3/9/2019)... ... 2019 , ... ACEA Biosciences Inc. (ACEA), now a part ... performance, cutting-edge cell analysis platforms for life science research. Today, ACEA ... and electrophysiology, are announcing a partnership to provide comprehensive in vitro cardiac safety ...
(Date:2/27/2019)... DIEGO, CALIF. (PRWEB) , ... February 27, 2019 ... ... expanding its service offering. Starting today, the San Diego-based team-building and cooking ... 30 people or more: Tacos + Tequila. , This fun-filled, interactive team-building event ...
(Date:2/22/2019)... ... 20, 2019 , ... Ocean Tomo Transactions, LLC will auction ... The patents in lot 92 relate to innovation for verifying human ... human users and computers through exploiting the fundamental differences between computer-based vision and ...
(Date:2/6/2019)... TORONTO (PRWEB) , ... February 05, 2019 , ... ... BDC Capital and the Firmex executive management team to acquire Firmex, one of ... sharing solutions, from Novacap, a Montreal-based private equity firm. Debt financing was provided ...
Breaking Biology Technology:
Cached News: