HOME >> BIOLOGY >> NEWS
Dartmouth researchers expose weakness of common parasite

Hanover, NH Dartmouth Medical School geneticists in the Department of Microbiology and Immunology have discovered how to weaken a common human parasite to prevent disease in an animal model after infection by the normal parasite. The work, reported in the February 21 issue of Nature, opens new avenues for the development of vaccines and other treatments for diseases such as toxoplasmosis caused by a diverse, but related group of protozoan parasites.

Barbara A. Fox, a research associate, and David J. Bzik, PhD, associate professor of microbiology and immunology, found that inactivating a single enzyme in a key biochemical pathway prevented Toxoplasma gondii from causing disease.

The T. gondi parasite, most commonly spread through undercooked meat (and occasionally through cats), causes toxoplasmosis, which generally poses no problems in infected people, but can be life threatening in immunocompromised patients and cause severe birth defects in newborns from primary infections during pregnancy. T. gondii belongs to a family of parasites that include the human pathogens Cryptosporidium parvum, also a danger for immunocompromised patients, and Plasmodium falciparum, a cause of virulent malaria that kills more than 2 million children world-wide each year.

Fox and Bzik have devised a mutant T. gondii strain that causes no disease and, more importantly, provides protection against the normal parasite. "Because of the extraordinary ability of this mutant parasite to infect the animal host without apparent ill effects, this mutant could be used as a prototype vaccine strain," said Bzik.

"This parasite is amenable to further genetic manipulation; it has an amazing ability to elicit a strong immune response that is likely to be beneficial for certain vaccines targeted against other challenging infectious diseases or cancer," added Fox.

"Parasites have been around a long time and have become very proficient at stealing things from their host, if th
'"/>

Contact: Steve Snyder
dms.communications@dartmouth.edu
603-650-1492
Dartmouth Medical School
20-Feb-2002


Page: 1 2 3

Related biology news :

1. Dartmouth Medical School awarded $9 million grant for genomics research
2. Dartmouth study advances prion disease research
3. Dartmouth bioengineers develop humanized yeast
4. Dartmouth researchers find two circadian clocks in the same plant tissue
5. Dartmouth engineers closer to mass-producing therapeutic proteins
6. Arsenic in drinking water may be linked to cancer Dartmouth study finds
7. Dartmouth researchers put recycling in perspective
8. Dartmouth Medical School geneticists discover new role for antisense RNA
9. Dartmouth researchers identify multi-tasking circadian protein
10. New way found to see light through novel protein identified by Dartmouth geneticists
11. Cancer killing gene found by Dartmouth researchers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/1/2016)... , February 1, 2016 ... advancements to drive global touchfree intuitive gesture control market ... --> Rising sales of consumer electronics coupled with ... control market size through 2020 ... electronics coupled with new technological advancements to drive global ...
(Date:2/1/2016)... Fla. , Feb. 1, 2016  Wocket® smart wallet ( www.wocketwallet.com ... and television personality, Joey Fatone . Las Vegas ... greet fans. --> Las Vegas , where ... --> The new video ad was filmed at the Consumer ... appeared at the Wocket booth to meet and greet fans. ...
(Date:1/27/2016)... Jan. 27, 2016  Rite Track, Inc. a leading ... West Chester, Ohio announced today the ... staff, based in Austin, Texas , ... to provide modifications, installations and technical support offerings for ... of PLUS, commented, "PLUS has provided world class service ...
Breaking Biology News(10 mins):
(Date:2/4/2016)... -- ContraVir Pharmaceuticals, Inc. (NASDAQ: CTRV ), a ... targeted antiviral therapies, announced today that it will present ... held February 8-9, 2016, at the Waldorf Astoria New ... Healthcare Conference, taking place in New York ... Sapirstein , Chief Executive Officer of ContraVir, will provide ...
(Date:2/4/2016)... California (PRWEB) , ... February 04, 2016 , ... ... Intelligence (AI) and leading supplier of Semantic Graph Database technology has been recognized ... Database Products ” by Corporate America Magazine. , “At Corporate America, it’s our ...
(Date:2/3/2016)...   ViaCyte, Inc ., a leading, privately-held ... cell-derived islet replacement therapy for the treatment of ... that ViaCyte and Janssen Biotech, Inc., one of ... have agreed to consolidate the assets of the ... ViaCyte with an exclusive license to all BetaLogics ...
(Date:2/3/2016)... -- Ascendis Pharma A/S (Nasdaq: ASND ), a ... technology to address significant unmet medical needs, today announced ... Partners Global Healthcare Conference Location: , Waldorf Astoria, ... Time:  , 11:55am EST www.ascendispharma.com . ... audio webcast of this event will be posted to ...
Breaking Biology Technology:
Cached News: