HOME >> BIOLOGY >> NEWS
Dartmouth researchers expose weakness of common parasite

Hanover, NH Dartmouth Medical School geneticists in the Department of Microbiology and Immunology have discovered how to weaken a common human parasite to prevent disease in an animal model after infection by the normal parasite. The work, reported in the February 21 issue of Nature, opens new avenues for the development of vaccines and other treatments for diseases such as toxoplasmosis caused by a diverse, but related group of protozoan parasites.

Barbara A. Fox, a research associate, and David J. Bzik, PhD, associate professor of microbiology and immunology, found that inactivating a single enzyme in a key biochemical pathway prevented Toxoplasma gondii from causing disease.

The T. gondi parasite, most commonly spread through undercooked meat (and occasionally through cats), causes toxoplasmosis, which generally poses no problems in infected people, but can be life threatening in immunocompromised patients and cause severe birth defects in newborns from primary infections during pregnancy. T. gondii belongs to a family of parasites that include the human pathogens Cryptosporidium parvum, also a danger for immunocompromised patients, and Plasmodium falciparum, a cause of virulent malaria that kills more than 2 million children world-wide each year.

Fox and Bzik have devised a mutant T. gondii strain that causes no disease and, more importantly, provides protection against the normal parasite. "Because of the extraordinary ability of this mutant parasite to infect the animal host without apparent ill effects, this mutant could be used as a prototype vaccine strain," said Bzik.

"This parasite is amenable to further genetic manipulation; it has an amazing ability to elicit a strong immune response that is likely to be beneficial for certain vaccines targeted against other challenging infectious diseases or cancer," added Fox.

"Parasites have been around a long time and have become very proficient at stealing things from their host, if th
'"/>

Contact: Steve Snyder
dms.communications@dartmouth.edu
603-650-1492
Dartmouth Medical School
20-Feb-2002


Page: 1 2 3

Related biology news :

1. Dartmouth Medical School awarded $9 million grant for genomics research
2. Dartmouth study advances prion disease research
3. Dartmouth bioengineers develop humanized yeast
4. Dartmouth researchers find two circadian clocks in the same plant tissue
5. Dartmouth engineers closer to mass-producing therapeutic proteins
6. Arsenic in drinking water may be linked to cancer Dartmouth study finds
7. Dartmouth researchers put recycling in perspective
8. Dartmouth Medical School geneticists discover new role for antisense RNA
9. Dartmouth researchers identify multi-tasking circadian protein
10. New way found to see light through novel protein identified by Dartmouth geneticists
11. Cancer killing gene found by Dartmouth researchers

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Dartmouth researchers expose weakness common parasite

(Date:10/15/2014)... an unexpected extent. The outbreak does not follow the ... a new disease dynamic in regions, where it has ... National Academy of Sciences Leopoldina, acatech – the German ... the German Academies of Sciences and Humanities have presented ... the statement the academies call for the following consequences ...
(Date:10/15/2014)... 15, 2014   Neurotechnology , a provider ... availability of the VeriLook Surveillance 3.0 software ... real-time biometric face identification using live video streams ... The new version not only identifies faces in ... objects while they are moving through the video ...
(Date:10/14/2014)... house fly genome for the first time, revealing robust ... that thrives in pathogen-rich dung piles and garbage heaps. ... Genome Biology , will increase understanding of house ... adapt to resist insecticides, which could lead to novel ... and transmit more than 100 human and animal diseases, ...
Breaking Biology News(10 mins):Academies call for consequences from the Ebola virus epidemic 2Academies call for consequences from the Ebola virus epidemic 3Academies call for consequences from the Ebola virus epidemic 4Academies call for consequences from the Ebola virus epidemic 5VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 2VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 3House fly genome reveals expanded immune system 2
(Date:10/22/2014)... CA (PRWEB) October 22, 2014 ... from Sartorius, A & D Weighing, Rice Lake, ... CPA Semi-Micro Balance . The Sartorius CPA Semi-Micro ... an affordable high-quality, precise, and user-friendly laboratory balance. ... of laboratory equipment, their laboratory balances are well ...
(Date:10/22/2014)... (PRWEB) October 22, 2014 Physicians ... its cardiovascular pharmacogenetics menu, which enables healthcare providers ... With PCLS’s evidence-based results, healthcare providers are ... optimize their therapy, while minimizing risks for adverse ... U.S., according to the FDA [1] more than ...
(Date:10/22/2014)... ROCKVILLE, Md. , Oct. 22, 2014   ... company developing novel pathogen-specific therapies for serious infections and ... Office has issued a Notice of Allowance for a ... product in its C. difficile program, SYN-004. This ... to SYN-004 in the U.S. and adds to the ...
(Date:10/22/2014)... , Oct. 22, 2014 Nuvilex, Inc. (OTCQB: ... 400 million people worldwide are living with diabetes, with  ... by 2030.  The global market for diabetes treatments is ... 330,000 people worldwide died from pancreatic cancer.  Pancreatic cancer ... to cancer in the United States ...
Breaking Biology Technology:Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 2Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 3PCLS Announces Expansion of Cardiovascular Pharmacogenetic Testing Menu 2PCLS Announces Expansion of Cardiovascular Pharmacogenetic Testing Menu 3Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 2Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 3Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 4Nuvilex Brief Analyst Report: Thinking Outside the Box by BrokerBank Securities, Inc. 2
Cached News: