HOME >> BIOLOGY >> NEWS
Dartmouth researchers expose weakness of common parasite

Hanover, NH Dartmouth Medical School geneticists in the Department of Microbiology and Immunology have discovered how to weaken a common human parasite to prevent disease in an animal model after infection by the normal parasite. The work, reported in the February 21 issue of Nature, opens new avenues for the development of vaccines and other treatments for diseases such as toxoplasmosis caused by a diverse, but related group of protozoan parasites.

Barbara A. Fox, a research associate, and David J. Bzik, PhD, associate professor of microbiology and immunology, found that inactivating a single enzyme in a key biochemical pathway prevented Toxoplasma gondii from causing disease.

The T. gondi parasite, most commonly spread through undercooked meat (and occasionally through cats), causes toxoplasmosis, which generally poses no problems in infected people, but can be life threatening in immunocompromised patients and cause severe birth defects in newborns from primary infections during pregnancy. T. gondii belongs to a family of parasites that include the human pathogens Cryptosporidium parvum, also a danger for immunocompromised patients, and Plasmodium falciparum, a cause of virulent malaria that kills more than 2 million children world-wide each year.

Fox and Bzik have devised a mutant T. gondii strain that causes no disease and, more importantly, provides protection against the normal parasite. "Because of the extraordinary ability of this mutant parasite to infect the animal host without apparent ill effects, this mutant could be used as a prototype vaccine strain," said Bzik.

"This parasite is amenable to further genetic manipulation; it has an amazing ability to elicit a strong immune response that is likely to be beneficial for certain vaccines targeted against other challenging infectious diseases or cancer," added Fox.

"Parasites have been around a long time and have become very proficient at stealing things from their host, if th
'"/>

Contact: Steve Snyder
dms.communications@dartmouth.edu
603-650-1492
Dartmouth Medical School
20-Feb-2002


Page: 1 2 3

Related biology news :

1. Dartmouth Medical School awarded $9 million grant for genomics research
2. Dartmouth study advances prion disease research
3. Dartmouth bioengineers develop humanized yeast
4. Dartmouth researchers find two circadian clocks in the same plant tissue
5. Dartmouth engineers closer to mass-producing therapeutic proteins
6. Arsenic in drinking water may be linked to cancer Dartmouth study finds
7. Dartmouth researchers put recycling in perspective
8. Dartmouth Medical School geneticists discover new role for antisense RNA
9. Dartmouth researchers identify multi-tasking circadian protein
10. New way found to see light through novel protein identified by Dartmouth geneticists
11. Cancer killing gene found by Dartmouth researchers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/16/2017)... 2017  Veratad Technologies, LLC ( www.veratad.com ), an ... identity verification solutions, announced today they will participate as ... 15 thru May 17, 2017, in Washington ... Center. Identity impacts the lives of ... quickly evolving digital world, defining identity is critical to ...
(Date:4/18/2017)...  Socionext Inc., a global expert in SoC-based imaging and computing ... M820, which features the company,s hybrid codec technology. A demonstration utilizing ... Inc., will be showcased during the upcoming Medtec Japan at Tokyo ... Las Vegas Convention Center April 24-27. ... Click here for an image ...
(Date:4/11/2017)... Research and Markets has announced the addition ... their offering. ... tracking market to grow at a CAGR of 30.37% during the ... 2017-2021, has been prepared based on an in-depth market analysis with ... its growth prospects over the coming years. The report also includes ...
Breaking Biology News(10 mins):
(Date:10/9/2017)... ... October 09, 2017 , ... ... line of medical marijuana products targeting the needs of consumers who are incorporating ... Kindred takes place in Phoenix, Arizona. , As operators of two successful Valley ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... consulting for microscopy and surface analysis, Nanoscience Instruments is now expanding into ... a broad range of contract analysis services for advanced applications. Services will ...
(Date:10/7/2017)... , Oct. 6, 2017  The 2017 ... of three scientists, Jacques Dubochet, Joachim Frank ... developments in cryo-electron microscopy (cryo-EM) have ... within the structural biology community. The winners worked ... can now routinely produce highly resolved, three-dimensional images ...
(Date:10/6/2017)... D.C. (PRWEB) , ... October 06, 2017 , ... ... will host a lunch discussion and webinar on INSIGhT, the first-ever adaptive clinical ... Principal Investigator, Dana-Farber Cancer Institute. The event is free and open to the ...
Breaking Biology Technology:
Cached News: