Deadly to cattle and humans, prions may help other organisms survive, researchers find

Molecular studies in yeast have yielded surprising evidence that the contorted proteins known as prions, often deadly to cattle and humans, may serve a beneficial role in some organisms, and possibly in humans. By analyzing the gene sequences of yeast and more complex organisms, researchers at UC San Francisco have also found evidence that prions might be far more common than had been previously suspected.

The scientists also searched for and discovered a yeast species containing more than one kind of prion-forming protein, the first time a search has netted multiple prions in the same organism. The discoveries and analysis are published in the January 21 issue of the journal Cell.

Prions' capacity to replicate in the brains of cattle and humans is thought to cause deadly or debilitating disease. But the researchers have detected the prion-forming trait intact in distantly related yeast species spanning 300 million years of evolution, suggesting prions perform a function important to yeast survival, since traits conserved over evolutionary time tend aid survival. Other researchers have found that yeast with prions known as PSI+ are more resistant to certain environmental insults than those lacking prions, hinting at a possible prion role in yeast survival.

The research also sheds light on the mechanism underlying the "species barrier" that usually prevents prions in one species from infecting other species. The barrier has been thought to prevent the transmission of scrapie and mad cow disease from livestock to humans, but recently researchers found alarming evidence that in some cases prions from cattle may infect other species, including humans.

The research in Cell shows that at least in yeast, the species barrier is an inherent property of prions and does not require assistance from a helper protein, or chaperone. The specificity, the researchers found, results form a small, well defined region on the prion

Contact: Wallace Ravven
University of California - San Francisco

Page: 1 2 3

Related biology news :

1. Deadly listeriosis often occurs in clusters, research finds
2. Deadly coral toxin exposes ion pumps deepest secret
3. Deadly for bacteria, great for consumers
4. Researchers Discover A Common Proteins Deadly Role In Breast Cancer
5. In Logged Forests, Hunting of Wildlife Becomes Deadly Second Harvest
6. Researchers Develop First Way To Immunize Against A Deadly Bacterium
7. Scientists Discover Molecular Trigger Of Mucus Production, Suggesting First Treatment For Deadly Bronchitis, Other Diseases
8. UCSF Researchers Pinpoint Molecule That Triggers Deadly Progress Of Pulmonary Fibrosis
9. New Method For Destroying Potentially Deadly Toxins In Drinking Water
10. Gene Discovery Paves Way For Preventing Deadly Bacterial Shock
11. Cellular Target Of Leprosy, Deadly Viruses Found

Post Your Comments:

(Date:2/12/2019)... POWAY, Calif. (PRWEB) , ... February 12, 2019 , ... ... three years old, she partially tore one of her cruciate ligaments. Just one ... mellow dog by nature, was able to recover without surgical intervention and resumed her ...
(Date:2/11/2019)... ... February 11, 2019 , ... Bode Technology ... new forensic genealogy service offering to law enforcement investigators and crime laboratories. ... to develop ancestral relationships between samples and deliver leads to our clients. , ...
(Date:2/6/2019)... , ... February 04, 2019 , ... ... new Explorerâ„¢ story which provides insights to help individuals understand how the gut ... cardiovascular wellness. , After individuals eat foods that contain choline and L-carnitine, ...
Breaking Biology News(10 mins):
(Date:2/6/2019)... TORONTO (PRWEB) , ... February 05, 2019 , ... ... BDC Capital and the Firmex executive management team to acquire Firmex, one of ... sharing solutions, from Novacap, a Montreal-based private equity firm. Debt financing was provided ...
(Date:2/2/2019)... ... February 01, 2019 , ... Biomatlante, a world leader ... new CEO, Julien Dert, being effective on February 1st, 2019. , Graduated from ... management, in which more than 12 years in the Medical Device industry. Chief ...
(Date:1/30/2019)... TRIANGLE PARK, N.C. (PRWEB) , ... January 29, ... ... of Asklepios BioPharmaceutical, Inc. (AskBio), today announced the dosing of the first patient ... Pompe Disease is a serious disease associated with high morbidity and often ...
(Date:1/30/2019)... FRANCISCO (PRWEB) , ... January 30, 2019 , ... ... leader in microbial genomics, has awarded microbiome research support in study design, planning, ... State University led by Dr. Marc D. Cook, PhD, to study the interactions ...
Breaking Biology Technology:
Cached News: