Defects in 'orphan' inositol polyphosphates may be linked to manic depression, cancer

Lithium has been effective in the treatment of bipolar or manic depressive disease for more than 40 years yet scientists still don't understand fully how it works, that is, what target in the cell the lithium hit once it began circulating in the blood. Without this information, it is difficult to know how to create other, perhaps more effective drugs, or drugs that will work for patients who do not respond to lithium. A scientist who provided important insights into possible targets of lithium - and this year's recipient of the American Society for Biochemistry and Molecular Biology's Schering Plough Award -- will describe his current research on April 21 at the Experimental Biology 2002 meeting in New Orleans.

Dr. John D. York, Howard Hughes Medical Institute Assistant Investigator, Duke University Medical Center, focuses on the elucidation of communication pathways between cells - a process called signaling - and the mechanisms by which defects in these pathways may lead to diseases such as manic depression and cancer.

Dr. York is perhaps best known for identifying biological roles for "orphan" intracellular signaling molecules known in general as inositol polyphosphates, a discovery which changed how scientists regard inositol signaling and its possible impact on disease and the design of new therapies.

His own previous work illustrates the impact of these little understood molecules. As a graduate student, Dr. York took apart the three dimensional structure of inositol polyphosphate 1-phosphatase, an enzyme that many scientists suspected was the target of lithium. At the center of the enzyme he found and was able to characterize a unique structure he then used as a guide to identifying other enzymes that could serve as additional targets for lithium. This work also may provide the basis for the design of more specific drugs that may not have the negative side effects some patients experience on lithium. He found that lithium inhibits s

Contact: Sarah Goodwin
Federation of American Societies for Experimental Biology

Page: 1 2

Related biology news :

1. UCSF Scientists Report On A Transcription Factor That Could Stimulate Heart Cells To Repair Damage Caused By Heart Attacks Or Birth Defects
2. Researchers Isolate Gene For Heart And Facial Defects
3. Major Heart Defects Can Be Identified In Fetuses By 14 Weeks Of Gestation
4. Researchers Link Gene Defects To The Course Of A Deadly Form Of Heart Disease
5. Evidence Mounts Against Maintstream Dogma In Embryology, Could Shed New Light On Neurological Defects
6. Scientists Show How Defects Can Improve Technology In Science Magazines Special Issue On Materials Science
7. Stargazer Gene Provides New Clues To Calcium Channel Defects In Absence Epilepsy
8. Defects In Embryonic Development In Lunatic Fringe Knockout Mice
9. Gene Linked To Glaucoma, Hydrocephalus, And Other Birth Defects
10. Genetic mutations linked to the practice of burning coal in homes in China
11. Enzyme maintaining chromosome ends is linked to bone cancer recurrence, decreased survival

Post Your Comments:

(Date:10/5/2018)... SAN DIEGO (PRWEB) , ... October 04, 2018 , ... ... team-building cooking classes have become so popular. , Cooking appeals to companies ... such as group interaction, team cohesion, collaboration and decision-making skills. It’s also appealing ...
(Date:10/2/2018)... ... ... eight-year-old Labrador retriever. Like many labs, Stuart’s favorite thing in the world is to ... whenever anyone comes to our door, he grabs a toy to greet them, just in ... began limping and eventually could no longer play fetch. Though he was still a ...
(Date:10/1/2018)... ... 01, 2018 , ... NanoValent Pharmaceuticals, Inc ., (NanoValent) ... therapeutics, today announced the National Institute of Health (NIH) Small ... funding for two separate grants. These two grants will allow NanoValent to advance ...
Breaking Biology News(10 mins):
(Date:10/17/2018)... ... 2018 , ... Dr. Richard Amato, founder of Advanced Periodontics ... offering current and new patients the opportunity to enjoy improved tooth extraction, bone ... technology known as Piezosurgery® . As long-time believers in staying ahead of ...
(Date:10/17/2018)... , ... October 17, 2018 , ... ... and Phytophthora spp. have been validated by USDA’s Animal and Plant Health Inspection ... can use the assays with confidence and trust, knowing they will be able ...
(Date:10/16/2018)... ... October 16, 2018 , ... Infinity Healing ... briefing on a revolutionary technology that effectively treats pain, reduces the need for ... testified on how technology using photobiomodulation (PBM) has been effective for the treatment ...
(Date:10/16/2018)... (PRWEB) , ... October 15, 2018 , ... The American ... Award recipients. The leaders will receive their awards at the AMIA 2018 Annual ... symposium draws more than 2,500 attendees. This year garnered more than 700 submissions. The ...
Breaking Biology Technology:
Cached News: