HOME >> BIOLOGY >> NEWS
Dendreon identifies novel approach to improve immunization efficiency

Seattle, WA (Nov. 28, 2000) Researchers at Dendreon Corporation have reported a novel method for generating an enhanced immune response with potentially important implications for improving the efficiency of therapeutic cancer vaccines. The data, published in the December issue of Nature Biotechnology, highlights a method for modifying targets on cancer cells called antigens to facilitate activation of cytotoxic T cells a key component of the immune system responsible for destroying cancerous cells.

Cancer vaccines are designed to jumpstart the immune systems natural disease-fighting ability. Cytotoxic T-cells in particular have been shown to be directly responsible for killing cancerous cells. Cytotoxic T-cells are educated to detect antigens on cancer cells by dendritic cells immune system watchdogs that internalize and process antigens prior to bringing them to the attention of T-cells.

In their study, Dendreon researchers found that a cytotoxic T-cell response could be greatly enhanced by engineering an antigen in a way that optimizes its uptake and processing by dendritic cells. Their approach involves the addition of a peptidic sequence to a modified, soluble protein antigen. Researchers analyzed the T-cell response elicited by the modified antigen in mouse models and found that mice immunized with the modified antigen generated significant cytotoxic T-cell activity while mice that received unmodified antigen showed no T-cell response.

"Our research provides strong evidence that a robust, enhanced T-cell response can be elicited through this type of antigen engineering. These findings also complement our Antigen Delivery Cassette technology," said Dr. Reiner Laus, lead author of the publication and vice president of immunology at Dendreon Corporation. "This is a novel approach with important implications for the immunotherapy of cancer."

The methodology described in the report is applicable to the development of a variety of vacci
'"/>

Contact: Page Sargisson
p.sargisson@noonanrusso.com
415-677-4455 x 229
Noonan/Russo Communications
27-Nov-2000


Page: 1 2

Related biology news :

1. Long-term data on Dendreons Mylovenge vaccine presented at American Society of Hematology
2. Chemical genetics identifies SARS inhibitors
3. U of T study identifies possible stem cells in pancreas
4. New view of leukemia cells identifies best treatment options, Stanford researchers say
5. Study identifies genetics of fat metabolism, red wine link
6. Gene expression ratio identifies risk of recurrence in breast cancer patients receiving tamoxifen
7. Study identifies which patients can benefit from targeted lung cancer drug and why
8. Researcher identifies Irish potato famine pathogen
9. U Iowa study identifies damaging mechanism in transplants and heart attacks
10. Computer method identifies potentially active enzymes
11. New study identifies inhibitor of anthrax toxin

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/14/2019)... ... , ... Gateway Genomics , a leading developer of direct-to-consumer genetic tests ... annual Inc. 500|5000 list of fastest growing private companies, in the first year ... and generating revenue by March 31, 2015. Ranking in the list is determined by ...
(Date:8/6/2019)... Calif. (PRWEB) , ... August 06, 2019 , ... ... in veterinary stem cell manufacturing with clinical, regulatory and GMP manufacturing experience. ... Cells, Inc. (PSC). With extensive regulatory experience and one of the ...
(Date:8/4/2019)... ... August 02, 2019 , ... Bioclinica, a ... in advancing the development of medical therapies, announced today that Michael O’Neal, M.D., ... one of the “100 Most Inspiring People in the Life-Sciences Industry.” Dr. ...
Breaking Biology News(10 mins):
(Date:6/12/2019)... , ... June 12, 2019 , ... ... helium-based leak testing instruments for the Pharmaceutical, Biotechnology, Medical Device and Food Packaging ... has been signed. The agreement will grant exclusive rights for Zillion to represent ...
(Date:6/11/2019)... ... June 10, 2019 , ... ... will add 80 of its scientific journals to DeepDyve’s rental service for peer-reviewed ... DeepDyve’s continually expanding library of more than 20 million articles, sourced from more ...
(Date:6/11/2019)... ... June 11, 2019 , ... A study released today in ... are able to incorporate into human CD34+ cells, modifying their gene expression and ... increased the cells’ ability to lodge into bone marrow. This research performed by ...
(Date:5/31/2019)... ... May 29, 2019 , ... ... interest to our methodology, processes, and diagnostic techniques. The patent applications titled ... IP rights including our proprietary sleep scoring methodology. The approval and success ...
Breaking Biology Technology:
Cached News: