HOME >> BIOLOGY >> NEWS
Designer Molecules: Largest Protein Ever Created From Scratch Has Implications For Novel Drug Delivery And Diagnostics

For the last decade, scientists have been trying to accurately synthesize substances with shapes that mimic biological molecules, specifically proteins that drive important biochemical pathways in humans. So far, these attempts have made moderate strides, both in terms of size of the designed protein and the precision with which it folds from a string of amino acids to its final three-dimensional structure. Now, researchers at the University of Pennsylvania Medical Center have created the largest protein from scratch, with both a stable and predictable shape.

"The ability to do this really takes us out of the realm of tinkering with existing proteins to engineering entirely new proteins and polymers," says senior author William F. DeGrado, Ph.D., professor of biochemistry and biophysics. "We have shown that it is now possible to design a protein with a well-defined three-dimensional structure." The Penn group's findings appear in the May 11 issue of the Proceedings of the National Academy of Sciences.

DeGrado notes that implications of this advance in protein design could be as broad as those for natural proteins -- from manufacturing entirely new polymers for industrial catalysts to creating new pharmaceuticals.

To design a protein, scientists generally work backwards from nature in a two-step process. They first choose an existing three-dimensional protein structure and then, using complex computer programs, find a new sequence of amino acids that folds into the same shape as the natural protein. The Penn team's approach is one step removed from that. "We asked: Can we generate proteins that are inspired by nature but have no direct natural equivalent?," explains DeGrado.

The protein -- called alpha-3D -- was designed, produced, and characterized by Scott Walsh, a doctoral student in DeGrado's lab. Alpha-3D is a bundle of three counterclockwise-coiling helices whose general shape was inspired by a protein found in the common h
'"/>

Contact: Karen Young Kreeger
kreeger@mail.med.upenn.edu
215-614-0290
University of Pennsylvania School of Medicine
11-May-1999


Page: 1 2

Related biology news :

1. Designer diseases
2. Designer proteins
3. Designer molecules correct RNA splicing defects: New strategy for treating many diseases
4. Designer animals made easy
5. Designer diets: ACS symposium will explore relationships between diet and genes, August 28-29
6. Designer chemical offers Alzheimers hope
7. Designer solvents promise revolutionary pollution solution
8. Constructing "Designer" Plant Enzymes
9. Largest brain repair initiative in MS will speed strategies to restore nerve function
10. Largest fossil cockroach found: Site preserves incredible detail
11. Largest grant ever to Indiana U fuels Genomics Initiative

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/26/2020)... ... August 25, 2020 , ... ... mitochondria, in partnership with Essex Bio-Technology, a bio-pharmaceutical company specializing in Ophthalmology ... VISTA-2 study of SkQ1 ophthalmic solution in patients with moderate to severe ...
(Date:8/21/2020)... ... 18, 2020 , ... Sentien Biotechnologies, Inc., a clinical-stage biotechnology ... and Drug Administration (FDA) has approved the company’s Investigational New Drug (IND) application ... COVID-19. Approval of this IND allows Sentien to initiate a Phase 1/2 study ...
(Date:8/12/2020)... ... August 11, 2020 , ... Both Roche, based in Basel, ... license agreements with Housey Pharma’s HMI subsidiary to gain access to its core-enabling ... Research and Development spending in excess of US $10 billion. , Scientists at ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... (PRWEB) , ... August 11, ... ... a biopharmaceutical cold chain validation engineering firm, is making available for free ... the need to incorporate concurrent transport simulation testing into today’s biologics licensing ...
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is now offering ... 50 million stem cells total, patients may choose which extremities they would like treated. ... joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is obtained from ...
(Date:7/31/2020)... ... July 29, 2020 , ... eSource has long been touted as the solution ... history of eSource, the reasons it did not take off as quickly as people ... the industry is moving towards capturing data electronically for clinical trials and then repurposing ...
(Date:7/18/2020)... ... July 16, 2020 , ... “We are thrilled to deliver ... “It’s the only technology of its kind on the market and we were pleased ... the protective capacity of traditional cultured ingredients, creating a natural way to extend the ...
Breaking Biology Technology:
Cached News: