Designer Molecules: Largest Protein Ever Created From Scratch Has Implications For Novel Drug Delivery And D...( ousehold bacteria Staphylococcus aureus...)

Designer Molecules: Largest Protein Ever Created From Scratch Has Implications For Novel Drug Delivery And Diagnostics

ousehold bacteria Staphylococcus aureus. Alpha-3D is also three times larger than previously synthesized proteins.

"By designing larger proteins, we can make them more stable and thus easier to manipulate," says Walsh. The next step will be to build a specific function into the protein's structure. Currently, Walsh is retooling the surface of alpha-3D to cause it to bind to a variety of hormonal receptors. Natural proteins that do this are expensive to produce and suffer from limited shelf lives. Novel mimics of these proteins may have enhanced stability and potency.

This work was conducted in the Johnson Research Foundation, a funding and research organization within Penn's Department of Biochemistry and Biophysics that concentrates on the study of physics as it applies to medicine.

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Contact: Karen Young Kreeger
kreeger@mail.med.upenn.edu
215-614-0290
University of Pennsylvania School of Medicine
11-May-1999

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