HOME >> BIOLOGY >> NEWS
Designer chemical offers Alzheimer's hope

Researchers at the University of Illinois at Chicago have designed and synthesized highly potent inhibitor compounds that could lead to an effective treatment for Alzheimers disease. The work was reported in the American Chemical Societys Journal of Medicinal Chemistry.

Arun Ghosh, professor of chemistry, led the UIC research team in collaboration with Jordan Tang, head of the Protein Studies department at the Oklahoma Medical Research Foundation in Oklahoma City.

In earlier work, Ghosh and Tang designed an inhibitor that blocks the action of one of two protein-cutting enzymes, called proteases, thought to be responsible for Alzheimers disease. This enzyme, called memapsin 2, severs a longer protein in the brain called amyloid precursor protein, or APP, to produce beta-amyloid, which accumulates in the brain and forms plaques that lead to the development of Alzheimers disease.

This enzyme is probably the most exciting target for an Alzheimers drug, said Ghosh.

Tang discovered the precise location where memapsin 2 cuts APP. Subsequently, Tang and Ghosh demonstrated that a model inhibitor compound attracts memapsin 2 and keeps it from cutting APP a promising way to halt accumulation of beta-amyloid in the brain. That inhibitor was reported in the Journal of the American Chemical Society last year and was shown to be effective in test tube experiments.

The research team knew that while useful as a model, the inhibitor would not be effective in drug therapy. That was a preliminary inhibitor, said Ghosh. Its a big one, containing eight peptides a size that is inconceivable to be a drug candidate.

Ghosh and his team set out to reduce the molecules size in an effort to increase its potential as a drug candidate.

Peptide-like compounds never make useful drugs because theyre metabolically unstable, theyre insoluble and, perhaps the biggest problem in Alzheimers patients, theyre hard to deliver in the human brain
'"/>

Contact: Paul Francuch
francuch@uic.edu
312-996-3457
University of Illinois at Chicago
2-Aug-2001


Page: 1 2

Related biology news :

1. Designer diseases
2. Designer proteins
3. Designer molecules correct RNA splicing defects: New strategy for treating many diseases
4. Designer animals made easy
5. Designer diets: ACS symposium will explore relationships between diet and genes, August 28-29
6. Designer solvents promise revolutionary pollution solution
7. Designer Molecules: Largest Protein Ever Created From Scratch Has Implications For Novel Drug Delivery And Diagnostics
8. Constructing "Designer" Plant Enzymes
9. DNA lends scientists a hand, revealing new chemical reactions
10. Grant advances biochemical engineering laboratory
11. Bullish chemical could repel yellow fever mosquitoes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/28/2020)... ... May 27, 2020 , ... ... Workforce Advisor™ , a solution that uniquely combines lab testing insights and hc1’s ... systematically support the ongoing health and safety of employees returning to the workplace. ...
(Date:5/28/2020)... , ... May 28, 2020 , ... ... that interim results from their 1801 Phase 1/2 study (NCT03678883, EudraCT #: 2018-003739-32) ... Meeting which will take place virtually on May 29th, 2020. Dr. Benedito Carneiro, ...
(Date:5/25/2020)... ... May 22, 2020 , ... Oxford Nanopore Technologies is ... of SARS-CoV-2, the virus that causes COVID-19. , The LamPORE assay is ... smaller sample numbers, to very large numbers of samples. Hardware and reagents sit ...
Breaking Biology News(10 mins):
(Date:5/14/2020)... ... May 12, 2020 , ... DuPont Nutrition ... distribution partner for all personal care ingredients in Russia and Belarus. Beginning May ... preservative portfolio for personal care. , The GENENCARE®OSMS product line contains ...
(Date:5/9/2020)... ANGELES (PRWEB) , ... May 08, 2020 , ... ... episode of their successful business program on Sunday, May 10, 2020 and Wednesday, May ... U.S. coast! This episode’s exclusive interviews will spotlight key executives from Techolution ...
(Date:5/1/2020)... NEW YORK (PRWEB) , ... April 30, 2020 ... ... Ideas Awards were announced today, honoring the businesses, policies, projects, and concepts that ... is a revolutionary bioprinter for living cells, which has taken out the top ...
(Date:4/22/2020)... CHESTER, Ohio (PRWEB) , ... April 21, 2020 ... ... of Biophen™ FXIII chromogenic method for determination of FXIII. , Aniara Diagnostica, a ... strengthened its commitment to meeting today’s highest standards for product quality and cost-efficient ...
Breaking Biology Technology:
Cached News: