HOME >> BIOLOGY >> NEWS
Designer molecules correct RNA splicing defects: New strategy for treating many diseases

With a high-tech fix for faulty cellular editing, scientists at Cold Spring Harbor Laboratory have moved a step closer to developing treatments for a host of diseases as diverse as breast cancer, muscular dystrophy, and cystic fibrosis.

Many human diseases have been linked to defects in a cellular editing process called pre-messenger RNA splicing. Adrian Krainer, a molecular biologist at Cold Spring Harbor Laboratory, has spent years investigating this complex editing process, which takes the information coded in genes and makes it available for building proteins. In a new study published in the journal Nature Structural Biology, Krainer's team has devised a clever way to correct RNA splicing defects implicated in breast cancer and spinal muscular atrophy (a neurodegenerative disease). In principle, the technique could provide the ability to correct RNA splicing defects associated with any gene or disease.

For now, Krainer's method has been shown to work under the simplest of conditions -- in test tubes with small segments of RNA. The next step is to adapt the technique for use in living cells. Still, "It's a very promising approach," says molecular biologist Brenton Graveley, of the University of Connecticut Health Center. "There are a lot of hurdles to be overcome in terms of delivering the corrective molecules to the cells that need to be treated. But theoretically the exact same approach could be taken for any gene at all, and the list of genes that have defects at the level of RNA splicing is very long," says Graveley, who is familiar with the research but not involved in the study.

For cells to produce protein, DNA is first transcribed into pre-messenger RNA (RNA is a chemical cousin of DNA). Pre-messenger RNA is a "word-for-word" representation of a DNA sequence in the language of RNA. But for reasons that remain unclear to scientists, pre-messenger RNA molecules contain excess "words" that are removed by splicing to create mature me
'"/>

Contact: Peter Sherwood
sherwood@cshl.edu
516-367-6947
Cold Spring Harbor Laboratory
12-Jan-2003


Page: 1 2 3

Related biology news :

1. Designer diseases
2. Designer proteins
3. Designer animals made easy
4. Designer diets: ACS symposium will explore relationships between diet and genes, August 28-29
5. Designer chemical offers Alzheimers hope
6. Designer solvents promise revolutionary pollution solution
7. Designer Molecules: Largest Protein Ever Created From Scratch Has Implications For Novel Drug Delivery And Diagnostics
8. Constructing "Designer" Plant Enzymes
9. Tiny molecules have big potential as cancer drugs, Stanford researcher believes
10. Synthesized molecules studied as weapon to stop cell division in cancer cells
11. Scientists reinvent DNA as template to produce organic molecules

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/2/2020)... REDWOOD CITY, Calif. (PRWEB) , ... July 01, ... ... stage biotech company, presented its phase 1a findings of Neihulizumab, a biologic for ... annual conference in June 2020. Led by hemato-oncologist Dr. Paul J Martin of ...
(Date:6/28/2020)... Fla. (PRWEB) , ... June 25, 2020 , ... In ... focus on innovations in accelerated Point of Care Testing solutions (POCT). Check local listings ... Samples are collected at medical offices and are shipped to labs throughout the country. ...
(Date:6/23/2020)... ... June 23, 2020 , ... ... pleased to announce the next event in a series of TOPIQ webinars, which ... TOPIQ series of webinars was developed in response to social distancing measures that ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... Ariz. (PRWEB) , ... July 29, 2020 , ... R3 ... joint injections for only $3950. With 50 million stem cells total, patients may choose ... stem cell therapy works for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, ...
(Date:7/31/2020)... ... July 29, 2020 , ... Editas Medicine, Inc. ... of advanced delivery technologies, development, and manufacturing solutions for drugs, biologics, cell and ... a strategic partnership whereby Catalent will provide support for the development, manufacturing, and ...
(Date:7/22/2020)... ... , ... Join experts from Reed Tech , Gary Saner, Sr. Manager, ... hour live webinar on Thursday, August 13, 2020 at 11am EDT (4pm ... devices. Specifically, for medical devices, the NMPA has departments dealing with medical device registration ...
(Date:7/18/2020)... ... July 17, 2020 , ... dicentra , ... sciences and food industries, is pleased to announce that Charles Galea has joined ... Development. , Charles is an accomplished and results-driven sales executive with over 10 ...
Breaking Biology Technology:
Cached News: