HOME >> BIOLOGY >> NEWS
Development of important immune cells relies on more complicated influences than scientist had thought

Research by Penn Cancer Center's Abramson Family Cancer Research Institute shows it isn't all 'nurture' in the nature vs. nurture debate about how cells develop

Researchers studying the way immune cells differentiate have discovered that an important family of white blood cells divides into separate identities in a much more complicated fashion than current scientific theory has held. Led by Steven L. Reiner, MD, of the Abramson Family Cancer Research Institute at the Cancer Center of the University of Pennsylvania Medical Center, the researchers have overturned existing scientific belief that helper T cells are programmed to differentiate only by outside signals.

Instead, the researchers have shown that Th1 and Th2 cells -- which are involved in inflammatory and allergic responses, respectively -- develop in a delicate chronological pattern, and in response to both internal and external influences.

The finding, which will be published in the June 8 issue of the journal Science, clears a new path for inquiry in the development of drugs that can create reinforcements for the body's army of immune cells. "The cell isn't just a tabula rasa -- a blank slate completely open to outside instructions. The cell is actively making decisions on its own that are sometimes hard for us to see," said Reiner, an Associate Investigator for the Abramson Institute and an Associate Professor in Penn's Department of Medicine.

Establishing how these white blood cells develop will someday help scientists to manipulate their production, increasing the supply of Th1 cells to fight against some parasite-caused illnesses or intracellular bacterial infections such as tuberculosis, or pumping up the supply of Th2 cells to combat autoimmune diseases and extracellular microbes such as intestinal worms.

In their work, Reiner and his colleagues scrutinized the cascade of events that follow when uncommitted cells are exposed to a protein factor call
'"/>

Contact: Ellen O'Brien
ellen.obrien@uphs.upenn.edu
215-349-5659
University of Pennsylvania School of Medicine
6-Jun-2001


Page: 1 2

Related biology news :

1. Origin and Development of the Vertebrate Traits
2. GlaxoSmithKline Drug Discovery and Development Research Grant Program 2004
3. 2nd Annual CDB Symposium: Developmental Remodeling (March 29 - 31, 2004; Kobe, Japan)
4. The Virus-Cancer Link: Examining the Role of Viruses in the Development of Cancer
5. Development of hair depends on development of the hair channel
6. Development of prostate drug based on UT Southwestern research
7. ICSU to establish Science for Sustainable Development programme
8. Forum on Research and Development in FY 2002 Budget
9. Population-Development-Environment in Namibia: background readings
10. Symposium Probes Impact Of Toxins On Development
11. Researchers Discover Mechanism Of Cleft Palate Development

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/11/2019)... OTTAWA, Ontario (PRWEB) , ... ... ... creator of the world’s first on-site Legionella DNA test, today announced a ... commercial, and hospitality industries. , Through this strategic partnership, LiquiTech will integrate ...
(Date:7/5/2019)... ... 05, 2019 , ... SteriTrack Inc. is pleased to announce ... around the world. , Powered by Microsoft Azure, the Tractus™ software and ... operating theatres worldwide to address new global regulations mandating all medical devices and ...
(Date:6/19/2019)... ... ... Dahryn Trivedi, today released research results on the beneficial impact of biofield ... be beneficial for treating multiple bacterial diseases. , The preclinical trial shows:, ... decrease in weight , Over 8% alteration in melting point ...
Breaking Biology News(10 mins):
(Date:5/31/2019)... ... May 30, 2019 , ... Object Pharma, ... the strategic acquisition of Metabiologics, Inc., a globally recognized leader in the production ... and commercialization rights to a full spectrum of botulinum neurotoxins, as well as ...
(Date:5/21/2019)... ADDIS ABABA, Ethiopia (PRWEB) , ... May 21, ... ... Lehranstalt für Brauerei in Berlin (VLB) today officially opened the inaugural Africa Brewing ... the brewing and malting industry in Africa. The event, which is supported through ...
(Date:5/14/2019)... ... May 13, 2019 , ... Leak ... instruments for the Pharmaceutical, Biotechnology, Medical Device and Food Packaging Industries’ is excited ... website aims to improve LDA’s ability to communicate directly with the marketplace; serving ...
(Date:5/7/2019)... ... May 06, 2019 , ... ... for the growing number of repositories being asked to store cellular products ... the team of contributors who are world leaders, who have shared their expertise ...
Breaking Biology Technology:
Cached News: