HOME >> BIOLOGY >> NEWS
Diabetes in the elderly linked to fewer cellular 'power plants'

Elderly people may develop insulin resistance -- one of the major risk factors for diabetes -- because "power plants" in their muscle cells decline or fail with age, according to Howard Hughes Medical Institute researchers at Yale University School of Medicine.

In studies of young and elderly people, the researchers found that older people had lower levels of metabolic activity in their mitochondria, the "factories" that provide power to cells. The findings suggest that reduced mitochondrial activity underlies insulin resistance, which is a major contributor to type 2 diabetes in the elderly.

In another recent study the researchers also found that physical activity can enhance the number of mitochondria in muscle by activation of a key enzyme called AMP kinase. "This is yet another reason for seniors to maintain an active lifestyle," said the study's senior author, Gerald Shulman of the Howard Hughes Medical Institute at Yale. Shulman and his colleagues reported their findings in the May 16, 2003, issue of the journal Science.

According to Shulman, pinpointing the cause of type 2 diabetes in the elderly would help solve a major health problem. "Approximately one in four individuals over the age of 60 has type 2 diabetes, which is a remarkable statistic," said Shulman. "And, if you add impaired glucose tolerance, you're talking about forty percent of the population."

The estimated economic burden of diabetes in United States is about $100 billion per year, a substantial proportion of which is due to diabetes in the elderly, said the researchers.

At the biochemical level, the hormone insulin promotes the transfer of glucose in the blood into cells for energy production and storage. Mitochondria within the cells convert glucose and fatty acids into energy via oxidation.

According to Shulman, previous studies in his laboratory had shown that insul
'"/>

Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
15-May-2003


Page: 1 2 3

Related biology news :

1. Joslin Diabetes Center honors brothers living 70-plus years with type 1 diabetes
2. Joslin Diabetes Center adds first affiliate in California at Irvine Medical Center
3. Joslin Diabetes Center launches research section on developmental and stem cell biology
4. Joslin Diabetes Center releases new low impact exercise video
5. As obesity skyrockets, Joslin Diabetes Center urges action to stem the tide of type 2 diabetes
6. Diabetes drug may be new tool in treating breast cancer
7. Diabetes therapies and liquid memory may develop from micro fluid research, Science researchers say
8. Diabetes tied to altering of the hearts circadian clock
9. Bacteria From Gum Infections Associated With Diabetes, Chronic Lung Disease, UB Studies Find
10. New Findings On Receptor Regulation May Lead To Better Drugs For Diabetes
11. Researchers Identify And Isolate First Gene For A Form Of Insulin-Dependent Diabetes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/6/2019)... ... 2019 , ... VetStem Biopharma has long been ... experience. In November it spun out a human regenerative medicine subsidiary, ... of the first cGMP cell manufacturing facilities in California , VetStem signed ...
(Date:8/6/2019)... ... August 05, 2019 , ... ... announce its attendance at the Microscopy & Microanalysis 2019 Meeting ( M&M 2019 ... Oregon Convention Center. , The Microscopy & Microanalysis Meeting, organized by the Microscopy ...
(Date:8/4/2019)... ... August 02, 2019 , ... Stay on top of current hot topics ... industries. Access to all webinars is free, so be sure to register today to ... Visit http://www.xtalks.com to see our upcoming webinars: , CLINICAL OPERATIONS , August ...
Breaking Biology News(10 mins):
(Date:8/23/2019)... ... August 22, 2019 , ... An upcoming ... is scheduled to broadcast 4Q/2019. Check your local listings for more information. , ... generic drug delivery. Focusing on therapeutics for children and the elderly, viewers will ...
(Date:8/14/2019)... COLLEGE, Pa. (PRWEB) , ... August 13, 2019 ... ... in nuclear receptor and in vitro toxicology testing solutions, announced the appointment of ... healthcare industry experience to the Board. , Mark McLoughlin will lend his healthcare ...
(Date:8/8/2019)... ... August 08, 2019 , ... ... for sales and service organizations, today announced that the company’s Studio Intelligent ... for the IVA market . Inference will officially accept the award at Frost ...
(Date:8/6/2019)... DIEGO (PRWEB) , ... August 06, 2019 , ... ... Marketing Radio (LSMR) have joined forces in launching the biweekly SDBN BUZZ podcast ... further growth. SDBN BUZZ podcast will also serve to promote the region and ...
Breaking Biology Technology:
Cached News: