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Digging for genetic fossils: Hutchinson Center researchers solve structure of ancient biological molecule

otides, meaning that ribozymes must somehow make the most of what they've got."

The team found that the folding of the RNA into its active structure actually changes the chemical properties of its nucleotide building blocks, giving them a much broader range of chemical capabilities needed for catalysis. "We found that parts of the molecule actually change a lot as they come together to form the active site," said Ferr-D'Amar, who speculates that improved understanding of RNA activity could lead to the discovery of attractive targets for drug design, particularly in the area of antibiotics.


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Contact: Kristen Woodward
kwoodwar@fhcrc.org
206-667-5095
Fred Hutchinson Cancer Research Center
11-Apr-2001


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