HOME >> BIOLOGY >> NEWS
Disconnect between skin cells implicated in common skin cancer

A mutation that prevents skin cells from making normal connections with each other plays an unexpectedly early and important role in the development of the skin cancer, suggests a study published in the February 23, 2001 issue of Cell.

By altering one molecule in a skin cell-cell junction in mice researchers at the University of Chicago profoundly changed the skin and caused it to behave like a pre-cancerous condition called squamous cell carcinoma in situ. Squamous cell carcinoma is one of the two most common forms of skin cancer with more than one million cases reported in the United States each year.

"Although mutations of this molecule have been found in some types of cancer, it has generally been assumed that this was a late event following other mutations disrupting cell-cycle control," said Elaine Fuchs, Ph.D., Amgen Professor of Molecular Genetics and Cell Biology and a Howard Hughes Investigator at the University of Chicago, and lead investigator of the study.

"We discovered surprisingly, this component's loss appears to be a critical early event in the development of skin cancer," said Fuchs. "This molecule appears to be doing more than simply participating in cell-cell junctions."

The organization the skin's epidermal layer depends on cell-cell connections formed by two types of intercellular structures: adherens junctions and desmosomes. The molecule alpha-catenin plays a role in adherens junctions and connects these junctions to a dynamic structural framework in the cell, the actin cytoskeleton.

Their strategy was to breed a mouse that has had the gene for alpha-catenin removed, or knocked-out, selectively in skin cells. The mouse embryo developed normally until its skin and hair begin to develop, around the 14th day of gestation. As these specialized cells, called keratinocytes, developed they did not make adherens junctions. The alpha-catenin needed to anchor the junction was missing.

Changes in the skin of the knockout mouse wer
'"/>

Contact: Jeanne Galatzer-Levy
jgalatz@uchospitals.edu
773-702-6241
University of Chicago Medical Center
22-Feb-2001


Page: 1 2 3

Related biology news :

1. Disconnecting molecular handbrakes has drastic consequences
2. Landmark agreement between Samoa and UC Berkeley could help search for AIDS cure
3. New research suggests link between maternal diet and childhood leukemia risk
4. Fossils reveal direct link between global warming and genetic diversity in wildlife
5. Battle between bubbles might have started evolution
6. UCSD researchers are first to demonstrate molecular link between inflammation and cancer
7. New survey reveals insights into unique relationship between mothers and pediatricians
8. Study explains spatial orientation differences between sexes
9. New technique helps scientists reveal interactions between genes and drugs
10. Unique partnership between UH, FDA opens path for scientific exchange
11. Study supports association between HPV infection and head and neck cancer

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Disconnect between skin cells implicated common skin cancer

(Date:10/15/2014)... , Oct. 15, 2014 Sandata Technologies, ... home and community-based care, today announced it released ... Sandata,s Santrax® Electronic Visit Verification™ Solution (EVV™)  for ... a home health company founded in 1996 and ... . The study details the ...
(Date:10/15/2014)... Researchers have linked increased resistance to bacterial pneumonia in ... sex hormone estrogen. , Females are naturally more resistant ... of scientists has shown that increased resistance to bacterial ... nitric oxide synthase 3 (NOS3). They also show that ... the female sex hormone estrogen. , The team, lead ...
(Date:10/14/2014)... Research shows SIRT6—a protein known to inhibit the ... of skin cancers by turning on an enzyme that ... , Previously considered protective, SIRT6 is part of a ... genomic stability and prevent some of the genetic flaws ... can lead to cancer. This study, in the journal,s ...
Breaking Biology News(10 mins):Sandata Announces Case Study with Quality Care Services, Inc. 2Two-faced gene: SIRT6 prevents some cancers but promotes sun-induced skin cancer 2
(Date:10/18/2014)... The report "1,6-Hexanediol Market by ... to 2019", analyzes the global market on the ... the industry details such as the key drivers, ... regions. , Browse 81 Market Data Tables and ... TOC on “1,6-Hexanediol Market by Application and by ...
(Date:10/18/2014)... October 18, 2014 The Asia-Pacific hardware ... market in Asia-Pacific with analysis and forecast of revenue. ... is expected to reach $51,362.6 million by 2018, at ... Browse through the TOC of the Asia-Pacific hardware encryption ... analysis provided. This also provides a glimpse of the ...
(Date:10/18/2014)... 18, 2014 The Asian Electronic Medical Record ... Asian with analysis and forecast of revenue. The electronic medical ... to $2,328.0 million by 2018, at a CAGR of 9.4% ... the Asian Electronic Medical Record (EMR) market, to get an ... glimpse of the segmentation of the market in the same ...
(Date:10/18/2014)... According to a new market research report “Hydraulic Fracturing ... & Forecasts up till 2017”, hydraulic fracturing market will ... is expected to increase from $40 billion in 2012 ... the same period. North America is expected to lead ... hydraulic horse power supplied by the year 2011. , ...
Breaking Biology Technology:1,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 21,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 31,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 41,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 5The Asia-Pacific hardware encryption display market is expected to reach $51,362.6 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific hardware encryption display market is expected to reach $51,362.6 million by 2018 - New Report by MicroMarket Monitor 3The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 2The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 3The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 4The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 5Hydraulic Fracturing Market Projected To Reach $64 Billion by 2017 - New Report by MarketsandMarkets 2Hydraulic Fracturing Market Projected To Reach $64 Billion by 2017 - New Report by MarketsandMarkets 3Hydraulic Fracturing Market Projected To Reach $64 Billion by 2017 - New Report by MarketsandMarkets 4
Cached News: