HOME >> BIOLOGY >> NEWS
Disconnect between skin cells implicated in common skin cancer

A mutation that prevents skin cells from making normal connections with each other plays an unexpectedly early and important role in the development of the skin cancer, suggests a study published in the February 23, 2001 issue of Cell.

By altering one molecule in a skin cell-cell junction in mice researchers at the University of Chicago profoundly changed the skin and caused it to behave like a pre-cancerous condition called squamous cell carcinoma in situ. Squamous cell carcinoma is one of the two most common forms of skin cancer with more than one million cases reported in the United States each year.

"Although mutations of this molecule have been found in some types of cancer, it has generally been assumed that this was a late event following other mutations disrupting cell-cycle control," said Elaine Fuchs, Ph.D., Amgen Professor of Molecular Genetics and Cell Biology and a Howard Hughes Investigator at the University of Chicago, and lead investigator of the study.

"We discovered surprisingly, this component's loss appears to be a critical early event in the development of skin cancer," said Fuchs. "This molecule appears to be doing more than simply participating in cell-cell junctions."

The organization the skin's epidermal layer depends on cell-cell connections formed by two types of intercellular structures: adherens junctions and desmosomes. The molecule alpha-catenin plays a role in adherens junctions and connects these junctions to a dynamic structural framework in the cell, the actin cytoskeleton.

Their strategy was to breed a mouse that has had the gene for alpha-catenin removed, or knocked-out, selectively in skin cells. The mouse embryo developed normally until its skin and hair begin to develop, around the 14th day of gestation. As these specialized cells, called keratinocytes, developed they did not make adherens junctions. The alpha-catenin needed to anchor the junction was missing.

Changes in the skin of the knockout mouse wer
'"/>

Contact: Jeanne Galatzer-Levy
jgalatz@uchospitals.edu
773-702-6241
University of Chicago Medical Center
22-Feb-2001


Page: 1 2 3

Related biology news :

1. Disconnecting molecular handbrakes has drastic consequences
2. Landmark agreement between Samoa and UC Berkeley could help search for AIDS cure
3. New research suggests link between maternal diet and childhood leukemia risk
4. Fossils reveal direct link between global warming and genetic diversity in wildlife
5. Battle between bubbles might have started evolution
6. UCSD researchers are first to demonstrate molecular link between inflammation and cancer
7. New survey reveals insights into unique relationship between mothers and pediatricians
8. Study explains spatial orientation differences between sexes
9. New technique helps scientists reveal interactions between genes and drugs
10. Unique partnership between UH, FDA opens path for scientific exchange
11. Study supports association between HPV infection and head and neck cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/13/2017)... April 13, 2017 According to a new market ... Identity Analytics, Identity Administration, and Authorization), Service, Authentication Type, Deployment Mode, Vertical, ... Market is expected to grow from USD 14.30 Billion in 2017 to ... of 17.3%. ... MarketsandMarkets Logo ...
(Date:4/11/2017)... N.Y. , April 11, 2017 ... fingerprints, but researchers at the New York University ... College of Engineering have found that partial similarities ... security systems used in mobile phones and other ... thought. The vulnerability lies in the ...
(Date:4/5/2017)... April 5, 2017  The Allen Institute for Cell ... Explorer: a one-of-a-kind portal and dynamic digital window into ... data, the first application of deep learning to create ... cell lines and a growing suite of powerful tools. ... these and future publicly available resources created and shared ...
Breaking Biology News(10 mins):
(Date:4/28/2017)... ... April 28, 2017 , ... While things have been quiet for EcoloCap ... and provide a new outlook for the future. As a continued effort to ... with the retirement of Mr. Siegel as CEO. With the new adjustments in management, ...
(Date:4/27/2017)... and RESEARCH TRIANGLE PARK, N.C. , ... UTHR ) today announced that its Board ... million of the company,s common stock. This program will ... 31, 2017. Purchases may be made in the open ... from time to time as determined by United Therapeutics, ...
(Date:4/27/2017)... ... 2017 , ... Proscia Inc., a data ... has the potential to eliminate subjectivity in the detection and classification of breast ... of the 2017 ISBI CAMELYON Digital Pathology Challenge, organized by the ...
(Date:4/27/2017)... ... April 27, 2017 , ... This month ... consent (eConsent) solution that simplifies research studies, accelerates study startup, and improves participant ... Q Consent™ is the first and only IRB-integrated eConsent solution . , ...
Breaking Biology Technology:
Cached News: