HOME >> BIOLOGY >> NEWS
Discovery Could Help Understand Breast-Cancer Therapies

CHAMPAIGN, Ill. -- Breast-cancer researchers at the University of Illinois have identified four amino acids viewed as leading actors in the binding of estrogen and anti-estrogen hormones to receptor proteins in the female reproductive system.

The findings could prove to be crucial in efforts to understand how the receptors respond to drug therapies and how they become resistant to tamoxifen, which, for 20 years, has been the anti-estrogen agent most commonly used against breast cancer in the United States, said lead researcher Benita Katzenellenbogen, a professor of molecular and integrative physiology.

The research was published in the Aug. 16 issue of The Journal of Biological Chemistry. The authors were Katzenellenbogen, who on Oct. 18 will receive the 1996 Komen Scientific Distinction Award from the Susan G. Komen Breast Cancer Foundation in Dallas; her husband, John Katzenellenbogen, professor of chemistry; Kirk Ekena, postdoctoral researcher; and Karen E. Weis, research associate.

The estrogen receptor is a protein containing about 600 amino acids. It takes in estrogen, providing the transcription signal (the message system) for biological activity important in bone maintenance, especially for postmenopausal women, and for cardiovascular protection. But estrogen also increases the risk of breast cancer in some women.

"We've identified portions of the hormone-binding domain of this protein that appear to be critical sites for binding with the hormone," Benita Katzenellenbogen said. "We've shown that if one alters one of these four amino acids then one eliminates the ability of estrogen to bind, and as a consequence one also eliminates the ability of these receptors to act as transcriptional regulators."

The research, funded by the National Institutes of Health, was conducted using a molecular biological technique called alanine-scanning mutagenesis, in which a different form of amino acid is substituted one at a
'"/>

Contact: Jim E. Barlow, Life Sciences Editor
b-james3@uiuc.edu
217-333-5802
University of Illinois at Urbana-Champaign
3-Oct-1996


Page: 1 2

Related biology news :

1. Discovery of new shrimp species adds to unique family
2. Discovery of tiny microbes in ancient Greenland glacier may define limits for life on Earth
3. Discovery in parasite movement may offer insights into malaria
4. Scientists find second way to kill cancer cells: Discovery opens possibilities for new therapies
5. GlaxoSmithKline Drug Discovery and Development Research Grant Program 2004
6. Discovery helps explain how cells package DNA
7. Discovery offers clues to origin of life
8. Discovery could improve anemia treatment in patients
9. Discovery could lead to better treatment for cryptosporidum infections
10. Discovery of brain disorder gene paves way for genetic test
11. Discovery may be first plant cell surface molecule that halts cell proliferation

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: