HOME >> BIOLOGY >> NEWS
Discovery Of A Molecule That Controls Bile Acids May Lead To New Cholesterol Drugs

DALLAS - May 21, 1999 - The discovery that a nuclear receptor controls the production of bile acids and works within a pathway that speeds up destruction of cholesterol may lead to new cholesterol drugs, UT Southwestern researchers reported in today's issue of Science.

Their finding -- that the receptor FXR (farnesoid orphan receptor) is integral to maintaining the balance of cholesterol and bile acids -- has important implications for developing drugs to control dietary cholesterol in humans, said corresponding author of the study Dr. David Mangelsdorf, associate professor of pharmacology and Howard Hughes Medical Institute (HHMI) investigator.

"Our finding that FXR functions as a bile-acid receptor suggests an expanded model for the regulation of cholesterol homeostasis by nuclear receptors," Mangelsdorf said. He and other researchers previously had shown that accumulation of dietary cholesterol in the liver triggers production of biochemicals called oxysterols. These substances activate liver orphan receptor (LXR) to speed up the breakdown of cholesterol for conversion to bile acids and steroid hormones.

"If we find an antagonist to FXR, then it might increase bile-acid production to control cholesterol," Mangelsdorf said. Both LXR and FXR are members of a family of protein molecules located in the nucleus of cells found in the liver, intestine, kidneys and adrenal glands. Their role in removing cholesterol from the body is important because it prevents arteriosclerosis, which leads to heart attacks.

This study showed that elevated bile acids regulated further production and transport through FXR. This leads Mangelsdorf to believe that FXR is one of the key regulators that controls repression and further synthesis in the liver and increases the production of other proteins that transport bile acids in the intestine.

"People can't live without bile acids as a way to rid the body of cholesterol, so o
'"/>

Contact: Susan Steeves
susan.steeves@email.swmed.edu
214-648-3404
UT Southwestern Medical Center
21-May-1999


Page: 1 2

Related biology news :

1. Discovery of new shrimp species adds to unique family
2. Discovery of tiny microbes in ancient Greenland glacier may define limits for life on Earth
3. Discovery in parasite movement may offer insights into malaria
4. Scientists find second way to kill cancer cells: Discovery opens possibilities for new therapies
5. GlaxoSmithKline Drug Discovery and Development Research Grant Program 2004
6. Discovery helps explain how cells package DNA
7. Discovery offers clues to origin of life
8. Discovery could improve anemia treatment in patients
9. Discovery could lead to better treatment for cryptosporidum infections
10. Discovery of brain disorder gene paves way for genetic test
11. Discovery may be first plant cell surface molecule that halts cell proliferation

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/10/2020)... ... ... Today CJ BIO announced the first in a series of Food Ingredient MasterClass webinars, ... revolutionizing ingredient mixes, nutritional content and flavor profiles across a range of savory foods ... AM (CDT) during SHIFT20, the virtual edition of the IFT Annual Meeting & Food ...
(Date:7/1/2020)... ... 2020 , ... Cure Glioblastoma, a registered 501(c)(3) nonprofit research ... adult brain cancer—announced today the appointments of its first Senior Fellows: John Boockvar, ... organization’s initiatives and overall vision. , "Senior Fellows are more than advisors; they ...
(Date:6/23/2020)... ... June 23, 2020 , ... First Aid Africa, ... a UK supplier and manufacturer of innovative portable renewable energy equipment, have announced ... fight against the COVID-19 pandemic in Zambia. , One of Renovagen’s FAST FOLD ...
Breaking Biology News(10 mins):
(Date:7/10/2020)... ... July 08, 2020 , ... Bode Technology, a ... laboratory operations through its COVID-19 testing service, Bode-CARES . Bode-CARES combines high-volume ... Bode-CARES provides a turnkey solution that includes a comprehensive collection and virus-management ...
(Date:7/7/2020)... ... , ... R3 International is now offering stem cell therapy for Alzheimers dementia ... on the patient's condition, treatment may be offered IV, intrathecal or with a combination. ... Alzheimers dementia, and the incidence continues to increase as individuals live longer. There is ...
(Date:7/1/2020)... ... June 30, 2020 , ... ... the launch of a new clinical diagnostics immuno-oncology service, TissueInsight . ... (TME). , “Flagship’s TissueInsight is a service that aids pathologists, oncologists, and ...
(Date:6/28/2020)... SPRING, Md. (PRWEB) , ... June 26, 2020 ... ... leading trade association representing security solutions providers, today announced its strong opposition to ... , The bill would impose a blanket ban on most federal use of ...
Breaking Biology Technology:
Cached News: