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Discovery Of Mechanism Causing Colon Cancer

gene.

In another experiment, the scientists introduced an adhesion molecule called cadherin into colon cancer cells. Cadherin is known to bind with beta-catenin at the outer periphery of the cell. Through this binding action, the cadherin "trapped" beta-catenin, preventing it from traveling to the nucleus and excessively stimulating the production of the cyclin D1 protein. A patent application for this method has been filed by Yeda Research and Development Co., the Weizmann Institute's technology transfer arm.

These types of intervention may provide the basis for developing future therapies for colon cancer, as well as for melanoma and other types of cancer in which the levels of beta-catenin are abnormally elevated.

Ben-Ze'ev's research team consisted of Weizmann Institute postdoctoral fellow Michael Shtutman, graduate student Jacob Zhurinsky and technical assistant Inbal Simcha. The group headed by Dr. Richard Pestell at the Albert Einstein College of Medicine included Dr. Chris Albanese and graduate student Mark D'Amico.

At the time this study was conducted, another research team, headed by Dr. Frank McCormick of the University of California at San Francisco, independently achieved similar results, pointing to the role of beta-catenin and cyclin D1 in colon cancer.

Prof. Ben-Ze'ev holds the Lunenfeld-Kunin Chair in Cell Biology and Genetics. This study was supported by the US-Israel Binational Science Foundation, the German- Israeli Foundation for Scientific Research and Development (GIF), the Cooperation Program in Cancer Research sponsored by the German Cancer Research Center (DKFZ) and the Israel Ministry of Science, and the Susan G. Komen Breast Cancer Foundation.


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Contact: Arthur Berger, VP Public Policy & Marketing
arthur@acwis.org
212-779-2500, Ext. 1
American Committee for the Weizmann Institute of Science
11-May-1999


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TAG: Discovery Mechanism Causing Colon Cancer

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