HOME >> BIOLOGY >> NEWS
Discovery Of Possible New Weight Control Role For Leptin Announced By Yale University School Of Medicine Researchers

New Haven, Conn. -- Researchers at Yale University School of Medicine and the Institutes for Pharmaceutical Discovery in Branford, Conn., have discovered a possible new mechanism for the body to control its fat stores by inducing the growth of new blood vessels, which suggests a new avenue for weight regulation.

The mechanism involves the action of leptin, a naturally occurring hormone known for its hunger-blocking effect on the hypothalamus, a region in the brain. According to a study published in the Sept. 11 issue of the journal Science, leptin also triggers the formation of new vessels in fat tissue, which may be a crucial adaptive response that provides more efficient release of metabolic energy and, thereby, weight loss.

The discovery was made by M. Rocio Sierra-Honigmann, M.D., Ph.D., associate research scientist in the Yale pathology department, and her husband Jaime Flores-Riveros, Ph.D, of the Institutes for Pharmaceutical Discovery (IPD), along with their colleagues.

"Now we have strong evidence for the existence of functional leptin receptors outside the brain, which could give us new insights into how leptin controls body fat besides blocking hunger," Sierra-Honigmann said.

"We were certainly puzzled by our initial observation that leptin receptors were present in endothelial cells lining blood vessels, a location never suspected to be a site of leptin action," said Flores-Riveros, a research director at IPD and previously a scientist in the Bayer Research Center in West Haven, Conn.

Other members of the research team were Anjali K. Nath, Chiaki Murakami, Guillermo Garcia-Cardena, Andreas Papapetropoulos, William C. Sessa, Lisa A. Madge, Jeffrey S. Schechner and Michael B. Schwabb of the Boyer Center for Molecular Medicine, Yale School of Medicine; and Peter J. Polvernini of the University of Michigan School of Dentistry.

According to Sierra-Honigmann, the growth of ne
'"/>

Contact: Cynthia Atwood
cynthia.atwood@yale.edu
203-432-1345
Yale University
10-Sep-1998


Page: 1 2 3

Related biology news :

1. Discovery of new shrimp species adds to unique family
2. Discovery of tiny microbes in ancient Greenland glacier may define limits for life on Earth
3. Discovery in parasite movement may offer insights into malaria
4. Scientists find second way to kill cancer cells: Discovery opens possibilities for new therapies
5. GlaxoSmithKline Drug Discovery and Development Research Grant Program 2004
6. Discovery helps explain how cells package DNA
7. Discovery offers clues to origin of life
8. Discovery could improve anemia treatment in patients
9. Discovery could lead to better treatment for cryptosporidum infections
10. Discovery of brain disorder gene paves way for genetic test
11. Discovery may be first plant cell surface molecule that halts cell proliferation

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/6/2019)... ... 05, 2019 , ... Keck Graduate Institute (KGI) President Sheldon Schuster has announced ... (SPHS). , “Dean Zdanowicz is highly regarded as an innovative leader who prioritizes student ... a great choice to build on the success of the KGI School of Pharmacy ...
(Date:8/1/2019)... ... August 01, 2019 , ... The GENSPEED platform is a compact, fast and ... fully developed with over 100 units deployed in the field for multiple applications. ... collaboration with axiVEND will give us a foothold in the USA to better support ...
(Date:8/1/2019)... ... August 01, 2019 , ... USDM Life Sciences (USDM) announces that Jay Crowley, ... detailed webinar addressing challenges with the upcoming EU MDR IVDR regulations . ... held a variety of positions over his 26 years at the FDA, including developing ...
Breaking Biology News(10 mins):
(Date:7/11/2019)... ... ... At the most recent stem cell training course in Las ... R3 Heroes Program. The Veterans included individuals and families from all over the US, ... a military Veteran, teacher or first responder to receive a regenerative therapy at a ...
(Date:7/2/2019)... ... July 02, 2019 , ... Leading Regenerative Veterinary Medicine company, ... Where Beasts Meet Biotech. The film focuses on regenerative veterinary medicine as a ... Pharm was recently included in the Brentwood and Pacific Palisades International Film ...
(Date:6/18/2019)... ... June 18, 2019 , ... Personalized Stem Cells, Inc ... application to the FDA for use of a person’s own adipose-derived stem cells to ... osteoarthritis in the knee. This IND is the first of several planned clinical ...
(Date:6/11/2019)... , ... June 10, 2019 , ... ... and technology in an upcoming episode, scheduled to broadcast 4Q/2019. Check your local ... Group) and will educate viewers about how its technology facilitates laboratories to improve ...
Breaking Biology Technology:
Cached News: