HOME >> BIOLOGY >> NEWS
Discovery could improve anemia treatment in patients

NOTE: This release has been updated since its original posting.

Patients with chronic inflammatory disorders, including infections, inflammatory bowel disease, arthritis and cancer, commonly become anemic. The anemia can make them sicker, is sometimes severe enough to require a blood transfusion, and responds only partially to current treatments. Researchers at Children's Hospital Boston, Harvard Medical School, and the European Molecular Biology Laboratory have unraveled the complicated biology behind this type of anemia and propose new targets for drug development. They report their findings in the April 18 edition of Nature Genetics.

A Children's Hospital team led by Cindy Roy in CHB's Division of Hematology/Oncology previously showed that anemia of chronic disease results from over-activation of hepcidin, a hormone involved in controlling iron in the body. Hepcidin is triggered by inflammation and may also help fight infection, both by directly inactivating pathogens and by reducing the amount of iron circulating in the blood. This "iron withholding" deprives infectious pathogens of a nutrient they need to proliferate, but it also reduces the iron available to developing red blood cells. As a result, patients become anemic.

Now, Roy and colleagues have identified a key regulator of hepcidin, a protein called HFE. The researchers showed that genetically engineered mice with deficiencies in HFE maintained elevated levels of iron in the blood during inflammation. "What we've shown is that unless you have the HFE protein, you can't mount this iron-withholding response," says Roy, who holds a doctorate in cell biology. "By turning off HFE, you turn off hepcidin and it's ability to respond to inflammation."

Anemia of chronic disease is often treated with iron or erythropoietin, a growth hormone for red blood cells, but neither is fully effective because hepcidin blocks the necessary iron from getting to the red cells. "An important n
'"/>

Contact: Mary-Ellen Shay
mary.shay@childrens.harvard.edu
617-355-6420
Children's Hospital Boston
18-Apr-2004


Page: 1 2 3

Related biology news :

1. Discovery of new shrimp species adds to unique family
2. Discovery of tiny microbes in ancient Greenland glacier may define limits for life on Earth
3. Discovery in parasite movement may offer insights into malaria
4. Scientists find second way to kill cancer cells: Discovery opens possibilities for new therapies
5. GlaxoSmithKline Drug Discovery and Development Research Grant Program 2004
6. Discovery helps explain how cells package DNA
7. Discovery offers clues to origin of life
8. Discovery could lead to better treatment for cryptosporidum infections
9. Discovery of brain disorder gene paves way for genetic test
10. Discovery may be first plant cell surface molecule that halts cell proliferation
11. Discovery may help in war against fire ants

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/22/2019)... (PRWEB) , ... October 21, 2019 , ... Join ... MS, Director of Bioanalytical in a live session on Thursday, October 31, ... CRO partner. , A good CRO partner should have expertise in method development, ...
(Date:10/17/2019)... (PRWEB) , ... October 15, 2019 , ... ... Prepared Media for the Microbiological Community”. , Microbiology International currently manufactures ready-to-use culture ... company also offers pre-poured agar plates & liquid supplements. , This major step ...
(Date:10/15/2019)... ... 2019 , ... Erchonia, the global leader in the manufacturing ... in Orlando & 18th Annual Golf Tournament. The invite-only, four-day event starts ... Melbourne. , The first day will kick off with training and roundtable discussions ...
Breaking Biology News(10 mins):
(Date:9/24/2019)... ... September 24, 2019 , ... Drug resistance has been declared ... Health Organization, with MRSA becoming one of the most serious concerns. Hong Kong cannot ... cases of community-associated MRSA (CA-MRSA), or a seven-fold of the figure in 2007 – ...
(Date:9/24/2019)... , ... September 24, 2019 , ... In the past ... research led by faculty at South Dakota School of Mines & Technology ... microbes that attach to surfaces to form a slimy and yet strong layer which ...
(Date:9/17/2019)... ... September 17, 2019 , ... Geneticure, Inc., a Rochester ... today that the U.S. Patent and Trademark Office (USPTO) and European Patent Office ... class recommendations for hypertension treatment. , The patent applies to Geneticure’s first ...
(Date:9/17/2019)... (PRWEB) , ... September 16, 2019 , ... ... was co-located with the China Focus @ Biotech Week Boston, a forum organized ... and collaborations in healthcare innovation. , After a careful process of evaluation, twelve ...
Breaking Biology Technology:
Cached News: