HOME >> BIOLOGY >> NEWS
Discovery could improve anemia treatment in patients

ext step is to determine whether drugs that inhibit HFE or hepcidin will be useful," says Senior Investigator Dr. Nancy Andrews, a Howard Hughes Medical Institute investigator at Children's Hospital Boston and the Leland Fikes Professor of Pediatrics at Harvard Medical School.

Roy notes that it may not be desirable to inactivate hepcidin completely. The hormone's antimicrobial properties would be lost and allowing too much iron to circulate also can promote infection. "It's going to be a balance," Roy says. "If we manipulate hepcidin activity, we have to be very careful not to encourage infection while we're trying to resolve the anemia. The ideal would be to control infection while allowing enough iron for red blood cell production."

HFE has long been known to control iron absorption. Andrews' lab has previously shown that a lack or a defect in HFE causes an opposite condition -- hereditary hemochromatosis (iron overload). People with this condition absorb too much iron, and as iron levels build up, they can develop liver cancer, heart disease, and other fatal conditions. "Living organisms have evolved intricate mechanisms to regulate iron uptake and distribution so they can exploit iron's useful properties while avoiding toxicity," notes Andrews.

Andrews and Roy are intrigued by the interaction of HFE and hepcidin, because it suggests that HFE has an immunologic function as well as an iron-regulating function. "We don't yet understand the immunity connection," says Andrews, who also holds a doctorate in biology. "Many molecules important in iron metabolism are also involved in immune defense, or are related to molecules involved in immune defense. But we don't yet know why." EMBL Scientists Martina Muckenthaler and Matthias Hentze collaborated closely with the Children's/Harvard team to identify this link.

"Our results clearly link HFE to the development of this type of anemia. More importantly, it seems that you can affect HFE f
'"/>

Contact: Mary-Ellen Shay
mary.shay@childrens.harvard.edu
617-355-6420
Children's Hospital Boston
18-Apr-2004


Page: 1 2 3

Related biology news :

1. Discovery of new shrimp species adds to unique family
2. Discovery of tiny microbes in ancient Greenland glacier may define limits for life on Earth
3. Discovery in parasite movement may offer insights into malaria
4. Scientists find second way to kill cancer cells: Discovery opens possibilities for new therapies
5. GlaxoSmithKline Drug Discovery and Development Research Grant Program 2004
6. Discovery helps explain how cells package DNA
7. Discovery offers clues to origin of life
8. Discovery could lead to better treatment for cryptosporidum infections
9. Discovery of brain disorder gene paves way for genetic test
10. Discovery may be first plant cell surface molecule that halts cell proliferation
11. Discovery may help in war against fire ants

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/14/2019)... POWAY, Calif. (PRWEB) , ... November 13, 2019 , ... ... successfully enrolled the first patients in an FDA approved clinical trial for stem ... anniversary of the formation of the company as a subsidiary of VetStem Biopharma. , ...
(Date:11/12/2019)... HAUPPAUGE, N.Y. (PRWEB) , ... November 12, 2019 ... ... made-in-the-USA germicidal ultraviolet air and water purifiers, announced today that distributors voted their ... ® and MEGATRON ® water purifiers. , The most frequent maintenance task ...
(Date:11/6/2019)... ... November 06, 2019 , ... NDA Partners Chairman ... pharmaceutical industry executive with expertise in clinical pharmacology and pharmacometrics and a widely ... data analytics, has joined the firm as an Expert Consultant. , Dr. Stanski ...
Breaking Biology News(10 mins):
(Date:11/12/2019)... ... November 12, 2019 , ... Fiberstar, Inc., a global ... industry launched a new innovative website. , After extensive research, Fiberstar ... global visitors updated ingredient usage tables by food application and video tutorials. And, ...
(Date:11/6/2019)... (PRWEB) , ... November 06, 2019 , ... Diversified ... whole pieces of fruits and vegetables per hour to improve processing. , The DTI ... of multiple tons per hour to increase juice yields by up to 50% and ...
(Date:11/5/2019)... POWAY, Calif. (PRWEB) , ... November 05, 2019 , ... Ole, a German Shepherd, was ... difficulty with stairs and jumping. Though his energy level and his willingness to play ... to veterinary surgeon Dr. Holly Mullen of VCA Emergency Animal Hospital and Referral Center ...
(Date:10/30/2019)... ... October 30, 2019 , ... While using cold plasma ... students at South Dakota School of Mines & Technology are exploring new ... healthy cells alive. , If successful, the technique would prove to be a ...
Breaking Biology Technology:
Cached News: