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Discovery helps explain how cells package DNA

es the histone proteins by adding chemical units known as acetyl groups.

The present study shows that the Hat B enzymes not only chemically modify histone proteins in cytoplasm--the region of the cell outside the nucleus--but that they remain attached to the histones as the proteins travel into the nucleus.

There, Parthun and his colleague, Xi Ai, a graduate student in The Ohio State University biochemistry program, found that the molecular threesome is joined by a fourth member, the newly discovered protein, Hif1p.

Last, the complex is joined by a fifth and still-unidentified protein that helps with that final step: adding the histone to DNA to form chromatin.

Next, Parthun wants to learn why histones must be modified by the addition of acetyl groups during chromatin assembly. He also wants to understand the role of the Hif1 protein in the process and identify the unknown protein that's needed for the final step of chromatin assembly.


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Contact: Darrell E. Ward
Ward-15@medctr.osu.edu
614-293-3737
Ohio State University
30-Apr-2004


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