HOME >> BIOLOGY >> NEWS
Discovery may be first plant cell surface molecule that halts cell proliferation

CHAPEL HILL -- University of North Carolina at Chapel Hill scientists have discovered a unique protein on the surface membrane of plant cells, one that apparently contains both "on" and "off" molecular switches. Apart from its unique structure, the protein may be the first cell surface membrane receptor ever discovered in plants that regulates a key protein complex involved in cell growth and division. Known as the heterotrimeric G protein complex, it also is present in mammalian cells, including human.

The protein, known as AtRGS1, regulates the process of cell proliferation by turning the G protein complex off. A report of the discovery appears in today's (Sept. 19) issue of the journal Science.

The protein was discovered in Arabidopsis thaliana, a wild mustard weed. Completion of the Arabidopsis genome sequence in 2000, the first for a higher plant, made it ideal for molecular investigation such as this. In addition, this small weed has homologues or counterparts of many important human proteins, including some involved in diseases, such as cystic fibrosis and cancer.

"We have identified the first and a truly novel regulator of G protein signaling, or RGS signaling protein, in Arabidopsis," said Dr. Jin-Gui Chen, senior research associate in the department of biology and the report's first author. "This finding can be considered a breakthrough in G protein signaling."

Roughly 800 types of these cell receptors exist in human cells, said plant cell biologist Dr. Alan M. Jones, a senior study author and professor of biology in UNC's College of Arts and Sciences.

"These are the molecular targets for about half of the drugs in use today worldwide, which account for $9 billion a year in sales." Teasing out the complexities of how signals are transduced into action within cells also holds implications for agriculture. "The new RGS protein's function in the G protein signaling pathway may give us a handle on how fast plant org
'"/>

Contact: Leslie Lang
llang@med.unc.edu
919-843-9687
University of North Carolina School of Medicine
19-Sep-2003


Page: 1 2 3

Related biology news :

1. Discovery of new shrimp species adds to unique family
2. Discovery of tiny microbes in ancient Greenland glacier may define limits for life on Earth
3. Discovery in parasite movement may offer insights into malaria
4. Scientists find second way to kill cancer cells: Discovery opens possibilities for new therapies
5. GlaxoSmithKline Drug Discovery and Development Research Grant Program 2004
6. Discovery helps explain how cells package DNA
7. Discovery offers clues to origin of life
8. Discovery could improve anemia treatment in patients
9. Discovery could lead to better treatment for cryptosporidum infections
10. Discovery of brain disorder gene paves way for genetic test
11. Discovery may help in war against fire ants

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/3/2019)... , ... October 02, 2019 , ... Personalized Stem ... first patient in an FDA approved clinical trial for stem cell treatment of ... after formation of the company as a subsidiary of VetStem Biopharma. , PSC CEO, ...
(Date:9/30/2019)... ... September 30, 2019 , ... ... of innovative human mesenchymal stem/stromal cell (hMSC) biomanufacturing systems, today announced it ... “Ready-to-Print” (RTP) cellular product formats (patent number AU 2015259373). This new patent ...
(Date:9/25/2019)... ... September 25, 2019 , ... Deep Science Ventures (DSV), ... the world’s largest independent funder of cancer research. , Deep Science Ventures was founded ... systems-level view of the opportunity from the start, both at the industry and biological ...
Breaking Biology News(10 mins):
(Date:10/10/2019)... ... October 09, 2019 , ... ... PhD, Principal Deputy Commissioner, FDA, as a newly-confirmed keynote speaker for the ... Las Vegas, Nevada USA. , Dr. Abernethy, a hematologist/oncologist and palliative medicine physician, ...
(Date:10/10/2019)... ... October 10, 2019 , ... VirTrial today ... centers in Europe. All Pratia research centers have completed VirTrial’s Virtual Trial Capable ... certified as Virtual Trial Capable and prepared to conduct decentralized clinical trials (DCT). ...
(Date:10/8/2019)... ... October 08, 2019 , ... Today, Massachusetts stem cell biotechnology ... development technology. Like the company’s precursor patent, approved in the U.S. in 2017, ... tissue stem cells. Asymmetrex now markets the technology in the U.S. as the ...
(Date:10/3/2019)... ... October 02, 2019 , ... Today marked the ... is enabling clinical program outsourcing success by cultivating radical improvements in leadership, staff, ... veteran executive Brenda Reese, phaseUP™ brings clients deep, broad and unique expertise in ...
Breaking Biology Technology:
Cached News: