Dismantling Dangerous Genetic Codes With A Faster, More Flexible RNA Mimic

OK, so maybe you can't fool Mother Nature, but that hasn't stopped a chemist at Washington University in St. Louis from imitating her.

James K. Bashkin, D. Phil., assistant professor of chemistry at Washington University, has created a molecule that mimics the behavior of a kind of naturally occurring RNA (ribonucleic acid) called a ribozyme, which acts as a catalyst. Bashkin's ribozyme mimic can dismantle the dangerous genetic codes involved in propagating viral and fungal diseases, certain cancers and even the HIV virus. The discovery shows great promise for improved viral and cancer chemotherapy and other potential drug treatments.

In 1994, Bashkin was the first scientist to make synthetic ribozymes, and the first to publish on the concept, which was conceived and patented in the mid-1980s while working with colleagues at Monsanto's Corporate Research Laboratories in St. Louis. About the same time, two other researchers suggested an alternative, organic approach to ribozyme mimics, which differed from Bashkin's metal-based ideas. Since then, several academic research groups and biotechnology companies have been hot on the trail of developing and testing Bashkin's ribozyme mimic design, or variations of it.

In the May 1998 issue of the Journal of Chemical Communications, Bashkin reported a newer, improved ribozyme mimic with the flexibility to home in on several specific regions of an HIV gene and cleave the RNA to destroy the harmful genetic message. He reported a higher level of specificity and greater dismantling speed than before. Several biotechnology companies now are planning to test the mimics in live cell cultures, moving Bashkin's concept closer to clinical trials.

"Dramatic Control"

"We've developed dramatic control over the specificity of the mimics as well as their reaction rate, or speed," said Bashkin. "Specificity is important because if you miss the targeted spot, you have the possibility of damaging normal RNA. S

Contact: Tony Fitzpatrick
Washington University in St. Louis

Page: 1 2 3 4 5

Related biology news :

1. Dangerous beauty: Fungal flowers offer clues to biofilm formation on medical implants
2. A Quick DNA Test Seeks Out A Dangerous Bacteria That Lurk In Food
3. Rare Fossil Shows Dinosaurs As Fast, Dangerous
4. Rare Fossil Shows Theropod Dinosaurs Are Fast, Dangerous Turbocharged Reptiles
5. New Sensor Adds Precision To Search For Dangerous Gases
6. Dangerous Chemical Combination Presents Possible Scenario For Gulf War Illnesses
7. Genetic mutations linked to the practice of burning coal in homes in China
8. Genetic differences might help distinguish thyroid cancers
9. Genetic modification of linseed produces healthier omega 3 and 6 fatty acids
10. Wiley publishes Welcome to the Genome: A Users Guide to the Genetic Past, Present, and Future
11. Genetically modified bacterium as remedy for intestinal diseases

Post Your Comments:

(Date:7/17/2019)... ... July 16, 2019 , ... Imagine using a simple, portable test ... loss before it causes osteoporosis. For South Dakota School of Mines & Technology researcher ... game-changer in terms of our ability to monitor and prevent disease,” says Wang. ...
(Date:7/9/2019)... ... July 08, 2019 , ... On June 27, ... of the innovation behind two Danisco amylase patent applications (EP2859097 and EP2825643). The ... on prior art was without merit and awarded costs to Danisco. , ...
(Date:6/20/2019)... (PRWEB) , ... June 19, 2019 , ... ... announced by the Infectious Diseases Society of America Foundation, and the possibly millions ... Aging to study infectious agents in AD, are a “welcome affirmation” of the ...
Breaking Biology News(10 mins):
(Date:5/31/2019)... ... May 30, 2019 , ... Object Pharma, Inc., a ... acquisition of Metabiologics, Inc., a globally recognized leader in the production and sale ... rights to a full spectrum of botulinum neurotoxins, as well as a CDC ...
(Date:5/15/2019)... , ... May 15, 2019 , ... Milton Hershey School® ... recognition for his work within the biomedical industry, where he is changing lives by ... devices. , “William Harding epitomizes the vision of our founders – Milton and ...
(Date:5/8/2019)... ... May 07, 2019 , ... Standing at 16.2 hands, Atlas is on the large ... a drill team and barrel racing, among other activities. When loping around a corner ... went from being a busy horse to only being able to walk. Fortunately Atlas’ ...
(Date:5/2/2019)... ... April 30, 2019 , ... ... ISO 9001:2015 standard, REPROCELL USA Inc. has demonstrated its ability to provide ... USA Inc. aims to enhance customer satisfaction through the effective implementation of ...
Breaking Biology Technology:
Cached News: