HOME >> BIOLOGY >> NEWS
Doctors Find Lead On Common Genes Which Can Lead To Bowel Cancer

Doctors from the Imperial Cancer Research Fund, London, England have taken a step closer to identifying people who should be screened for bowel cancer. In new findings published this month (September 1998) in the Proceedings of the National Academy of Sciences* the research team confirm that two variants of the APC gene (a gene already associated with familial bowel cancer) do make people more susceptible to developing pre-cancerous polyps and thus predisposes them to bowel cancer.

Sir Walter Bodmer, head of the charity's Cancer and Immunogenetics Laboratory, Oxford explained: "We have found a new category of susceptibility to bowel cancer. What is interesting about these variants is that although they are hereditary their effect is not so strong as the other mutations which have already been identified with familial bowel cancer."

Dr Ian Frayling, Clincial Research Fellow with Imperial Cancer's Bowel Cancer Unit at St Mark's Hospital, added: "Not everyone who carries these variants of the APC gene will develop bowel cancer and so someone who carries the gene won't necessarily have a family history of the disease, but they might be at an increased risk of bowel cancer nonetheless."

Inherited mutations in the APC gene are responsible for a condition called Familial Adenomatous Polyposis (FAP) in which gene carriers get hundreds, often thousands, of polyps in their bowel and if the condition is not treated by surgery bowel cancer will develop. FAP is very rare (1 in 8000 individuals), but accounts for about one half a per cent of bowel cancer.

Added Dr Ian Tomlinson, head of Imperial Cancer's Molecular and Population Genetics Laboratory: "These new variants have a much more subtle effect and could be more common than the ones responsible for FAP. Someone who carries a standard APC gene mutation will have a risk of bowel cancer 40 times higher than normal. The risk for someone with one of these weaker variants may only be 5 times normal."
'"/>

Contact: Christine Suggars
suggars@icrf.icnet.uk
+44-171-269-3614
Imperial Cancer Research Fund
8-Sep-1998


Page: 1 2 3

Related biology news :

1. Doctors miss chances to help pregnant women quit smoking
2. Doctors miss chance to advise women of vitamin that prevents birth defects, survey finds
3. Doctors perform more IVF treatments, but multiple births decline
4. Doctors aware of Tylenol-related liver risk - but is the public getting the message?
5. Doctors failure to reevaluate asthma severity hurts wheezing sufferers
6. One In Three Doctors Recommends Herbal Supplements To Patients
7. Plant Doctors Find Genetic Solution For Papaya Growers
8. Phase Out Planned For One Of Top Five U.S. Pesticides, Plant Doctors Respond
9. New Heart-Attack Indicator Dramatically Improves Diagnostic Accuracy Of ER Doctors: TnT/Echocardiogram Combination Could Reduce Needless Admissions
10. Common cold virus can cause polio in mice when injected into muscles
11. Common call for action on European Research Council (ERC)

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/26/2016)... -- Research and Markets has announced the ...  report to their offering.  , ,     (Logo: ... forecast the global multimodal biometrics market to grow ... 2016-2020.  Multimodal biometrics is being implemented ... healthcare, BFSI, transportation, automotive, and government for controlling ...
(Date:4/14/2016)... , April 14, 2016 ... and Malware Detection, today announced the appointment of ... the new role. Goldwerger,s leadership appointment comes ... the heels of the deployment of its platform at ... behavioral biometric technology, which discerns unique cognitive and physiological ...
(Date:3/29/2016)... LegacyXChange, Inc. (OTC: LEGX ... Protect are pleased to announce our successful effort to ... of writing instruments, ensuring athletes signatures against counterfeiting and ... athletes on LegacyXChange will be assured of ongoing proof ... Bill Bollander , CEO states, "By inserting ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... Calif. , June 23, 2016  Blueprint Bio, ... biological discoveries to the medical community, has closed its ... Matthew Nunez . "We have received ... with the capital we need to meet our current ... essentially provide us the runway to complete validation on ...
(Date:6/23/2016)... ... June 23, 2016 , ... ClinCapture, the only free ... and will showcase its product’s latest features from June 26 to June 30, ... poster on Disrupting Clinical Trials in The Cloud during the conference. DIA ...
(Date:6/23/2016)... FRANCISCO , June 22, 2016  Amgen (NASDAQ: ... sponsorship of the QB3@953 life sciences incubator ... human health. The shared laboratory space at QB3@953 was ... overcome a key obstacle for many early stage organizations ... part of the sponsorship, Amgen launched two "Amgen Golden ...
(Date:6/22/2016)... , June 22, 2016 Research and ... Global Markets" report to their offering. ... billion in 2014 from $29.3 billion in 2013. The market is ... of 13.8% from 2015 to 2020, increasing from $50.6 billion in ... projected product forecasts during the forecast period (2015 to 2020) are ...
Breaking Biology Technology:
Cached News: