HOME >> BIOLOGY >> NEWS
Doctors Find Lead On Common Genes Which Can Lead To Bowel Cancer

Doctors from the Imperial Cancer Research Fund, London, England have taken a step closer to identifying people who should be screened for bowel cancer. In new findings published this month (September 1998) in the Proceedings of the National Academy of Sciences* the research team confirm that two variants of the APC gene (a gene already associated with familial bowel cancer) do make people more susceptible to developing pre-cancerous polyps and thus predisposes them to bowel cancer.

Sir Walter Bodmer, head of the charity's Cancer and Immunogenetics Laboratory, Oxford explained: "We have found a new category of susceptibility to bowel cancer. What is interesting about these variants is that although they are hereditary their effect is not so strong as the other mutations which have already been identified with familial bowel cancer."

Dr Ian Frayling, Clincial Research Fellow with Imperial Cancer's Bowel Cancer Unit at St Mark's Hospital, added: "Not everyone who carries these variants of the APC gene will develop bowel cancer and so someone who carries the gene won't necessarily have a family history of the disease, but they might be at an increased risk of bowel cancer nonetheless."

Inherited mutations in the APC gene are responsible for a condition called Familial Adenomatous Polyposis (FAP) in which gene carriers get hundreds, often thousands, of polyps in their bowel and if the condition is not treated by surgery bowel cancer will develop. FAP is very rare (1 in 8000 individuals), but accounts for about one half a per cent of bowel cancer.

Added Dr Ian Tomlinson, head of Imperial Cancer's Molecular and Population Genetics Laboratory: "These new variants have a much more subtle effect and could be more common than the ones responsible for FAP. Someone who carries a standard APC gene mutation will have a risk of bowel cancer 40 times higher than normal. The risk for someone with one of these weaker variants may only be 5 times normal."
'"/>

Contact: Christine Suggars
suggars@icrf.icnet.uk
+44-171-269-3614
Imperial Cancer Research Fund
8-Sep-1998


Page: 1 2 3

Related biology news :

1. Doctors miss chances to help pregnant women quit smoking
2. Doctors miss chance to advise women of vitamin that prevents birth defects, survey finds
3. Doctors perform more IVF treatments, but multiple births decline
4. Doctors aware of Tylenol-related liver risk - but is the public getting the message?
5. Doctors failure to reevaluate asthma severity hurts wheezing sufferers
6. One In Three Doctors Recommends Herbal Supplements To Patients
7. Plant Doctors Find Genetic Solution For Papaya Growers
8. Phase Out Planned For One Of Top Five U.S. Pesticides, Plant Doctors Respond
9. New Heart-Attack Indicator Dramatically Improves Diagnostic Accuracy Of ER Doctors: TnT/Echocardiogram Combination Could Reduce Needless Admissions
10. Common cold virus can cause polio in mice when injected into muscles
11. Common call for action on European Research Council (ERC)

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Doctors Find Lead Common Genes Which Can Lead Bowel Cancer

(Date:11/4/2014)... PA) – Temple University School of Medicine announced ... winner, an initiative funded by the Bill & ... Professor of Obstetrics, Gynecology and Reproductive Sciences; and ... Temple University School of Medicine will pursue an ... "Maternal Blood Biomarkers to Assess Fetal Neurodevelopment.", Grand ...
(Date:11/4/2014)... VILNIUS, Lithuania , Nov. 4, 2014 /PRNewswire/ ... identification technologies, today announced that the latest version ... place in the Ongoing MINEX evaluation ... interoperability of fingerprint algorithms using the INCITS 378 ... a mandatory requirement in public tenders in ...
(Date:11/2/2014)... In this month,s issue of Physics World , ... bridging the "valley of death" to take their innovations ... argues that the gruelling challenge facing all start-up companies ... harder for physicists because of two main factors: physics-based ... and they often turn out to be a lot ...
Breaking Biology News(10 mins):Temple University School of Medicine receives Grand Challenges Explorations grant 2Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 2Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 3The 'valley of death' facing physics start-ups 2
(Date:11/22/2014)... November 21, 2014 On November 17th ... the 2014 Emerging Medical Technologies Summit in San Francisco ... Widely regarded among Silicon Valley investors and technology ... innovation, the win also positions Briteseed to move ... competition in 2015 and compete with other elite innovation ...
(Date:11/22/2014)... 2014 Respiratory therapy students will ... management of life-like respiratory ailments using the latest ... Grand Rapids-based, Michigan Instruments Inc. developers of the ... the respiratory simulation units to the pro-gram, which ... and Muskegon Community College are collaborating to offer ...
(Date:11/22/2014)... 2014   , ... Officer zu KLOX    ... Financial Officer bestellt    KLOX ist ... jüngst zugelassenen Behandlungssystems zur Wundheilung zu beginnen    , ... ist sehr erfreut, die folgenden personellen Veränderungen anzukündigen: ...
(Date:11/21/2014)... 21, 2014   TRU-D SmartUVC LLC and its ... UVC automated disinfection robot, TRU-D SmartUVC, at FIS 2014 in ... 23 to 26 at Stand 23. The conference, ... United Kingdom,s largest infection-related event of its kind ... one of the leading events of its type throughout the ...
Breaking Biology Technology:Insight Product Development Accelerator Member Wins MedTech Innovator Award Competition 2Insight Product Development Accelerator Member Wins MedTech Innovator Award Competition 3Michigan Instruments Donates Two Respiratory Simulation Training and Test Lung (TTL) Devices to Grand Valley State University 2Michigan Instruments Donates Two Respiratory Simulation Training and Test Lung (TTL) Devices to Grand Valley State University 3KLOX Technologies meldet Neubesetzung von Führungspositionen 2KLOX Technologies meldet Neubesetzung von Führungspositionen 3KLOX Technologies meldet Neubesetzung von Führungspositionen 4KLOX Technologies meldet Neubesetzung von Führungspositionen 5TRU-D SmartUVC to Showcase Superbug-Killing Robot at FIS 2014 2TRU-D SmartUVC to Showcase Superbug-Killing Robot at FIS 2014 3
Cached News: