HOME >> BIOLOGY >> NEWS
Doctors Find Lead On Common Genes Which Can Lead To Bowel Cancer

Doctors from the Imperial Cancer Research Fund, London, England have taken a step closer to identifying people who should be screened for bowel cancer. In new findings published this month (September 1998) in the Proceedings of the National Academy of Sciences* the research team confirm that two variants of the APC gene (a gene already associated with familial bowel cancer) do make people more susceptible to developing pre-cancerous polyps and thus predisposes them to bowel cancer.

Sir Walter Bodmer, head of the charity's Cancer and Immunogenetics Laboratory, Oxford explained: "We have found a new category of susceptibility to bowel cancer. What is interesting about these variants is that although they are hereditary their effect is not so strong as the other mutations which have already been identified with familial bowel cancer."

Dr Ian Frayling, Clincial Research Fellow with Imperial Cancer's Bowel Cancer Unit at St Mark's Hospital, added: "Not everyone who carries these variants of the APC gene will develop bowel cancer and so someone who carries the gene won't necessarily have a family history of the disease, but they might be at an increased risk of bowel cancer nonetheless."

Inherited mutations in the APC gene are responsible for a condition called Familial Adenomatous Polyposis (FAP) in which gene carriers get hundreds, often thousands, of polyps in their bowel and if the condition is not treated by surgery bowel cancer will develop. FAP is very rare (1 in 8000 individuals), but accounts for about one half a per cent of bowel cancer.

Added Dr Ian Tomlinson, head of Imperial Cancer's Molecular and Population Genetics Laboratory: "These new variants have a much more subtle effect and could be more common than the ones responsible for FAP. Someone who carries a standard APC gene mutation will have a risk of bowel cancer 40 times higher than normal. The risk for someone with one of these weaker variants may only be 5 times normal."
'"/>

Contact: Christine Suggars
suggars@icrf.icnet.uk
+44-171-269-3614
Imperial Cancer Research Fund
8-Sep-1998


Page: 1 2 3

Related biology news :

1. Doctors miss chances to help pregnant women quit smoking
2. Doctors miss chance to advise women of vitamin that prevents birth defects, survey finds
3. Doctors perform more IVF treatments, but multiple births decline
4. Doctors aware of Tylenol-related liver risk - but is the public getting the message?
5. Doctors failure to reevaluate asthma severity hurts wheezing sufferers
6. One In Three Doctors Recommends Herbal Supplements To Patients
7. Plant Doctors Find Genetic Solution For Papaya Growers
8. Phase Out Planned For One Of Top Five U.S. Pesticides, Plant Doctors Respond
9. New Heart-Attack Indicator Dramatically Improves Diagnostic Accuracy Of ER Doctors: TnT/Echocardiogram Combination Could Reduce Needless Admissions
10. Common cold virus can cause polio in mice when injected into muscles
11. Common call for action on European Research Council (ERC)

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/28/2017)... , March 28, 2017 The ... Hardware (Camera, Monitors, Servers, Storage Devices), Software (Video Analytics, ... Region - Global Forecast to 2022", published by MarketsandMarkets, ... 2016 and is projected to reach USD 75.64 Billion ... and 2022. The base year considered for the study ...
(Date:3/24/2017)... 24, 2017 The Controller General of Immigration from ... Abdulla Algeen have received the prestigious international IAIR Award for the ... Continue Reading ... ... Controller Abdulla Algeen (small picture on the right) have received the IAIR ...
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based ... to 2022", published by MarketsandMarkets, the market is expected to be worth USD ... 2022. Continue Reading ... ... ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... and LAGUNA HILLS, Calif. , Oct. ... Cancer Research, London (ICR) and University ... SKY92, SkylineDx,s prognostic tool to risk-stratify patients with multiple myeloma ... MUK nine . The University of Leeds ... partly funded by Myeloma UK, and ICR will perform the ...
(Date:10/10/2017)... ... 2017 , ... San Diego-based team building and cooking events company, Lajollacooks4u, has ... The bold new look is part of a transformation to increase awareness, appeal to ... period. , It will also expand its service offering from its signature gourmet cooking ...
(Date:10/10/2017)... 10, 2017 International research firm Parks Associates announced ... at the TMA 2017 Annual Meeting , October 11 in ... residential home security market and how smart safety and security products impact ... Parks Associates: Smart Home ... "The residential security market has ...
(Date:10/9/2017)... DIEGO , Oct. 9, 2017  BioTech ... biological mechanism by which its ProCell stem cell ... critical limb ischemia.  The Company, demonstrated that treatment ... amount of limbs saved as compared to standard ... the molecule HGF resulted in reduction of therapeutic ...
Breaking Biology Technology:
Cached News: