HOME >> BIOLOGY >> NEWS
Dog Blindness Gene May Help Humans

ITHACA, N.Y. -- Two groups of researchers collaborating on a map of the canine genome have discovered the probable genetic correlation between the most widespread cause of inherited blindness in dogs and a similar human disease.

The scientists, working at Cornell University's James A. Baker Institute for Animal Health and the Fred Hutchinson Cancer Research Center in Seattle, report their findings in Proceedings of the National Academy of Sciences published tomorrow (March 17). They say that the genetic defect responsible for progressive rod-cone degeneration (called prcd), a form of progressive retinal atrophy known to cause blindness in at least five dog breeds, appears to be the canine version of the human gene defect producing RP17, one of the numerous forms of retinitis pigmentosa, a leading cause of familial blindness.

Before this latest research, no association had been suspected between RP17 and prcd. Now the researchers consider it likely that RP17 and prcd spring from mutations in corresponding genes in humans and dogs.

"If this is true, the identification of the prcd gene may lead not only to an unequivocal diagnostic test for dogs but also to gene therapy methods for prcd in dogs -- which eventually may be applicable to human RP17 patients," says veterinary ophthalmologist and geneticist Gregory Acland, the lead author of the report and a senior research associate in the laboratory of Gustavo Aguirre at the Baker Institute, a unit of Cornell's College of Veterinary Medicine.

"This is an important finding for the field of canine genetics as well, since it represents the first use of the map for identifying a disease locus," says Elaine Ostrander, a molecular biologist in Hutchinson's clinical research division and a co-author of the report.

"It is exciting that we now have a road map and have identified signposts indicating where to look for the defective gene causing prcd, a possibility that did not exist before," adds co-au
'"/>

Contact: Roger Segelken
hrs2@cornell.edu
607-255-9736
Cornell University News Service
16-Mar-1998


Page: 1 2 3

Related biology news :

1. Research to Prevent Blindness awards $4.8 million
2. Ribozymes To The Rescue: New UF Gene Therapy Shows Promise For Treatment Of Inherited Blindness
3. Genetic Clue Found To The Leading Cause Of Blindness In The United States
4. Blindness Linked To The Cytoskeleton?
5. Scientists Identify Key Protein Involved In Progressive Blindness
6. UNMC, Boys Town National Research Hospital Researchers Locate Gene That Causes Combined Deafness And Blindness
7. New Retinal Surgery May Reverse Legal Blindness
8. Humans march to a faster genetic drummer than primates, UC Riverside research says
9. Humans emerged out of Africa again and again
10. Humans hunted mammals to extinction in North America
11. Humans at work and play in high altitude environments

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... 2017 NXT-ID, Inc. (NASDAQ:   NXTD ... the appointment of independent Directors Mr. Robin D. Richards ... of Directors, furthering the company,s corporate governance and expertise. ... Gino Pereira , Chief ... to their guidance and benefiting from their considerable expertise as ...
(Date:4/5/2017)... 2017 Today HYPR Corp. , leading ... component of the HYPR platform is officially FIDO® ... security architecture that empowers biometric authentication across Fortune 500 ... secured over 15 million users across the financial services ... home product suites and physical access represent a growing ...
(Date:4/3/2017)... April 3, 2017  Data captured by ... platform, detected a statistically significant association between ... to treatment and objective response of cancer ... to predict whether cancer patients will respond ... as well as to improve both pre-infusion potency ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... 2017 , ... AMRI, a global contract research, development and ... outcomes and quality of life, will now be offering its impurity solutions as ... regulatory requirements for all new drug products, including the finalization of ICH M7 ...
(Date:10/11/2017)... ... October 11, 2017 , ... ComplianceOnline’s Medical Device Summit is back for ... June 2018 in San Francisco, CA. The Summit brings together current and former FDA ... board directors and government officials from around the world to address key issues in ...
(Date:10/11/2017)... TX (PRWEB) , ... October 11, 2017 , ... ... August compared the implantation and pregnancy rates in frozen and fresh in ... contribution of progesterone and maternal age to IVF success. , After comparing the ...
(Date:10/10/2017)... , ... October 10, 2017 , ... Dr. Bob Harman, ... his local San Diego Rotary Club. The event entitled “Stem Cells ... and had 300+ attendees. Dr. Harman, DVM, MPVM was joined by two human ...
Breaking Biology Technology:
Cached News: