BETHESDA, Md., Wed., July 14, 2004 The first draft of the dog genome sequence has been deposited into free public databases for use by biomedical and veterinary researchers around the globe, the National Human Genome Research Institute (NHGRI), one of the National Institutes of Health (NIH), announced today.

A team led by Kerstin Lindblad-Toh, Ph.D., of the Broad Institute of MIT and Harvard, Cambridge, Mass., and Agencourt Bioscience Corp., Beverly, Mass., successfully assembled the genome of the domestic dog (Canis familiaris). The breed of dog sequenced was the boxer, which was chosen after analyses of 60 dog breeds found it was one of the breeds with the least amount of variation in its genome and therefore likely to provide the most reliable reference genome sequence.

The initial assembly is based on seven-fold coverage of the dog genome. Researchers can access the sequence data through the following public databases: GenBank (http://www.ncbi.nih.gov/Genbank) at NIH's National Center for Biotechnology Information (NCBI); EMBL Bank (www.ebi.ac.uk/embl/index.html) at the European Molecular Biology Laboratory's Nucleotide Sequence Database; and the DNA Data Bank of Japan (www.ddbj.nig.ac.jp). The data can also be viewed through the UCSC Genome Browser (http://www.genome.ucsc.edu/) at the University of California at Santa Cruz and the Ensembl Genome Browser (www.ensembl.org) at the Wellcome Trust Sanger Institute in Cambridge, England. Viewing capabilities also will be available in August at NCBI's Map Viewer (http://www.ncbi.nlm.nih.gov/mapview/).

The NHGRI-supported researchers are currently comparing the dog and human genome sequences and plan to publish results of their an
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Contact: Geoff Spencer
spencerg@mail.nih.gov
301-402-0911
NIH/National Human Genome Research Institute
14-Jul-2004

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