HOME >> BIOLOGY >> NEWS
Don't slight the birdbrain

Scientists Coax Precursor Cells to Replace Neurons in Adult Zebra Finches

Boston, MA -- February 22, 2000 -- A little bird told Jeffrey Macklis that it might be possible, one day, to awaken the birth of new neurons inside a person's brain without transplantation of so-called stem cells from other sources.

In the February Neuron, Macklis, a neuroscientist at Boston's Children's Hospital, reports with his collaborators Constance Scharff and Fernando Nottebohm of Rockefeller University and others that they have coaxed high-level neurons in adult zebra finches to be replaced by the bird's endogenous precursor cells.

"This is, we believe, the first example where it has been demonstrated that one can induce the birth of new neurons and that they actually contribute to a complex behavior," says Macklis, associate professor of neurology (neuroscience) at Harvard Medical School. "It is a step toward attempting the same in mammals," he adds.

The study plays on one of the brain's more amazing feats: every fall, a population of song-generating neurons in the so-called high vocal center of canaries dies off and the birds fall quiet. Winter sees a wave of rebirth of the same kind -- and same number -- of neurons, and in the spring, the canaries learn their songs anew. Zebra finches lack this seasonal cycle; their brains generate a constant yet tiny trickle of new neurons.

This more limited ability resembles that of mammals, where scientists now agree that multipotent precursors line the brain's inner ventricles, but only two specific types of neurons, one in the olfactory bulb and one in the hippocampus, are known to regrow at low levels.

If zebra finches, and indeed humans, have cells that could potentially repopulate brain areas, the scientists wondered, then why do they not do so? To find out whether the answer lay in the precursors themselves or in the brain environment they encounter, they tested the notion that it is the death of ce
'"/>

Contact: Gabrielle Strobel
gabrielle_strobel@hms.harvard.edu
617-432-3121
Harvard Medical School
23-Feb-2000


Page: 1 2

Related biology news :

1. Dont always believe what you see, suggests study on false memories
2. Dont drink the water: Texas A&M researcher conducting study of polluted Mexican lake
3. Dont ban embryo-based research says new chairman of European fertility organisation
4. Dont be fooled about your oral health: AAP uncovers common misconceptions
5. Pain in the gut? Dont blame stomach acid
6. HIV-Positive Injection Drug Users Often Dont Receive Protease Inhibitors And May Not Be Aware Of The Drug
7. HIV-1 Levels In Semen Dont Correspond To Viral Levels In Blood, Say Pitt Researchers In A Report At 12th World AIDS Conference
8. Genetic Makeup May Explain Why Some Women Smokers Develop Breast Cancer While Others Dont, UB Study in JAMA Reports

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/14/2019)... ... ... Gateway Genomics , a leading developer of direct-to-consumer genetic tests that ... Inc. 500|5000 list of fastest growing private companies, in the first year the ... generating revenue by March 31, 2015. Ranking in the list is determined by the ...
(Date:8/6/2019)... ... August 06, 2019 , ... ... manufacturing with clinical, regulatory and GMP manufacturing experience. In November it spun ... With extensive regulatory experience and one of the first cGMP cell ...
(Date:8/4/2019)... , ... August 02, 2019 , ... ... the life science industry in advancing the development of medical therapies, announced today ... by PharmaVOICE magazine as one of the “100 Most Inspiring People in the ...
Breaking Biology News(10 mins):
(Date:7/17/2019)... ... July 16, 2019 , ... ... manufacturing of Zolgensma® (onasemnogene abeparvovec-xioi), an AveXis gene therapy treatment for spinal ... have dedicated manufacturing space at the new, state-of-the-art commercial manufacturing center near ...
(Date:7/2/2019)... ... ... Leading Regenerative Veterinary Medicine company, VetStem Biopharma , was recently featured ... focuses on regenerative veterinary medicine as a means of improving the quality of life ... the Brentwood and Pacific Palisades International Film Festival in Los Angeles, California where it ...
(Date:6/11/2019)... ... June 10, 2019 , ... Thought Technology Ltd ... appointment of Biofeedback Tech Ltd as its authorised distributor for the ... of many therapeutic treatments and clinical assessment protocols to treat stress related disorders ...
(Date:6/11/2019)... ... June 11, 2019 , ... A study released ... cells (MSC-EV) are able to incorporate into human CD34+ cells, modifying their gene ... MSC-EVs also increased the cells’ ability to lodge into bone marrow. This research ...
Breaking Biology Technology:
Cached News: