HOME >> BIOLOGY >> NEWS
Don't slight the birdbrain

Scientists Coax Precursor Cells to Replace Neurons in Adult Zebra Finches

Boston, MA -- February 22, 2000 -- A little bird told Jeffrey Macklis that it might be possible, one day, to awaken the birth of new neurons inside a person's brain without transplantation of so-called stem cells from other sources.

In the February Neuron, Macklis, a neuroscientist at Boston's Children's Hospital, reports with his collaborators Constance Scharff and Fernando Nottebohm of Rockefeller University and others that they have coaxed high-level neurons in adult zebra finches to be replaced by the bird's endogenous precursor cells.

"This is, we believe, the first example where it has been demonstrated that one can induce the birth of new neurons and that they actually contribute to a complex behavior," says Macklis, associate professor of neurology (neuroscience) at Harvard Medical School. "It is a step toward attempting the same in mammals," he adds.

The study plays on one of the brain's more amazing feats: every fall, a population of song-generating neurons in the so-called high vocal center of canaries dies off and the birds fall quiet. Winter sees a wave of rebirth of the same kind -- and same number -- of neurons, and in the spring, the canaries learn their songs anew. Zebra finches lack this seasonal cycle; their brains generate a constant yet tiny trickle of new neurons.

This more limited ability resembles that of mammals, where scientists now agree that multipotent precursors line the brain's inner ventricles, but only two specific types of neurons, one in the olfactory bulb and one in the hippocampus, are known to regrow at low levels.

If zebra finches, and indeed humans, have cells that could potentially repopulate brain areas, the scientists wondered, then why do they not do so? To find out whether the answer lay in the precursors themselves or in the brain environment they encounter, they tested the notion that it is the death of ce
'"/>

Contact: Gabrielle Strobel
gabrielle_strobel@hms.harvard.edu
617-432-3121
Harvard Medical School
23-Feb-2000


Page: 1 2

Related biology news :

1. Dont always believe what you see, suggests study on false memories
2. Dont drink the water: Texas A&M researcher conducting study of polluted Mexican lake
3. Dont ban embryo-based research says new chairman of European fertility organisation
4. Dont be fooled about your oral health: AAP uncovers common misconceptions
5. Pain in the gut? Dont blame stomach acid
6. HIV-Positive Injection Drug Users Often Dont Receive Protease Inhibitors And May Not Be Aware Of The Drug
7. HIV-1 Levels In Semen Dont Correspond To Viral Levels In Blood, Say Pitt Researchers In A Report At 12th World AIDS Conference
8. Genetic Makeup May Explain Why Some Women Smokers Develop Breast Cancer While Others Dont, UB Study in JAMA Reports

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/10/2019)... (PRWEB) , ... October 09, 2019 , ... ... Calcium Symposium (ISACS) 2019 at Executive Plaza Hotel in Vancouver, Canada on September ... the knowledge of the various measures to develop healthy bone and to prevent ...
(Date:10/8/2019)... ... October 08, 2019 , ... Enplug , a ... easier than ever for businesses and organizations to use their digital signage networks ... to count down to or count up from date-related milestones, while the Holidays ...
(Date:10/4/2019)... ... October 04, 2019 , ... ... be held November 10 at the Grand Elysée Hamburg Rothenbaumchaussee in Hamburg. , ... again this November,” said Miao Guo, Vice President of Operations and spokesperson for ...
Breaking Biology News(10 mins):
(Date:9/22/2019)... (PRWEB) , ... September 20, 2019 , ... ... launch of Brain-Derived Neurotrophic Factor (BDNF) testing in serum . BDNF plays ... systems. BDNF stimulates the growth and differentiation of new neurons in the brain ...
(Date:9/17/2019)... , ... September 17, 2019 , ... Tucker, a Labrador ... only four months old, Tucker was limping and lame on his right hip and ... dysplasia and it was called “the worst case the vet had seen.” He was ...
(Date:9/17/2019)... ... September 17, 2019 , ... Jennifer Hermansky and Fang Xie, ... named to Law360’s 2019 Rising Stars. Hermansky and Xie, named an Immigration Rising Star ... submissions, spanning 39 practice areas. The list highlights attorneys “whose legal accomplishments transcend their ...
(Date:9/17/2019)... ... September 16, 2019 , ... A ... Saturday, September 21st @11:00am ET. Check local listings for more information on this ... Biomedical), a molecular diagnostic company from Singapore dedicated to developing advanced diagnostic technologies ...
Breaking Biology Technology:
Cached News: