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DoubleTwist completes the first annotation of the human genome

Sun supercomputers used to process all available sequence data from the human genome project

DoubleTwist, Inc. and Sun Microsystems, Inc. (Nasdaq: SUNW) today announced that DoubleTwist has completed an extensive analysis of the currently available Human Genome Project data, revealing genes and other valuable information. This milestone was accomplished using Sun Enterprise(TM) supercomputers, including Starfire(TM)servers, and DoubleTwist's proprietary genomic analysis software and distributed processing system. DoubleTwist also announced that it will continue to analyze the Human Genome Project data from its 'working draft' to final form -- and make this data available to scientists on its genomic research portal DoubleTwist.com(TM).

"The Human Genome Project has done a tremendous job of providing the primary sequence of more than 80 percent of the genome to date. We have built upon this accomplishment by processing this data to reveal its most important information -- the genes," said John Couch, Chairman and Chief Executive Officer of DoubleTwist. "Further, we are providing a mechanism for scientists to easily view and mine this information on DoubleTwist.com."

"With today's announcement, the stage is set for a new era of discovery," said Greg Papadopoulos, Chief Technology Officer for Sun Microsystems, Inc. "What the Web browser is to the Internet, DoubleTwist.com is to the human genome. It makes this whole complex collection of information easy to use."

DoubleTwist's proprietary multi-step genomic analysis pipeline includes multiple validated gene prediction algorithms, as well as methodologies based on elucidating DNA and protein similarities. To accomplish the initial annotation of the human genome and to facilitate on-going genomic processing, DoubleTwist has developed a distributed processing system that facilitates high-throughput processing and analysis.

"Finding genes
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Contact: Joan Kureczka, J. Kureczka Associates
JKureczka@aol.com
415-821-2413
Kureczka/Martin Associates
7-May-2000


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