HOME >> BIOLOGY >> NEWS
Drug bottles containing natural rubber stoppers may place latex allergic patients at risk for reactions

Armed with evidence from a recent study of latex allergy skin reactions in patients, scientists at Johns Hopkins encourage the Food and Drug Administration (FDA) and drug makers to label all current vials as "containing natural rubber" where appropriate and convert to using synthetic rubber for all medicine bottle stoppers.

If a drug is sold and stored in vials with a natural rubber stopper, no matter what precautions you take, latex allergens can contaminate that drug, says Robert Hamilton, Ph.D., professor of medicine at Johns Hopkins University. The FDA has asked for evidence that such allergens are present in pharmaceutical vials and that they can induce reactions in individuals already allergic to latex. Now we can provide it to them. Until the FDA requires all vials to be labeled as "containing natural rubber" for easy identification and that the stoppers be latex free, some sensitized individuals will be at risk for a potentially serious or fatal allergic reaction. Hamilton and his team make these recommendations based on a new study, reported in the June issue of the Journal of Allergy and Clinical Immunology, of 12 allergic and 11 non-allergic volunteers. All underwent puncture and intradermal skin testing with solutions from drug vials, two with natural rubber latex stoppers and three with synthetic stoppers. Two latex-allergic individuals had skin reactions even when the rubber stopper was not punctured and five had reactions when the stopper was punctured 40 times before testing. It is not unusual for drug vials to be frequently punctured by syringe needles, since vials contain multiple doses. Non-allergic individuals were not similarly affected.

The evidence from this study indicates that these stoppers pose a risk for reactions, says Hamilton. Even without a complete switch to synthetic stoppers, short-term solutions may help avoid allergic reactions and save lives. Doctors and pharmacists can ask, for example, whether their patients ha
'"/>

Contact: Kate O'Rourke
korourke@jhmi.edu
410-955-8665
Johns Hopkins Medical Institutions
7-Jun-2001


Page: 1 2

Related biology news :

1. Component in plastic bottles found to cause abnormal pregnancies in mice
2. National report containing Stanford research recommends path for future genome study
3. Genistein-containing supplements may stop tamoxifen
4. Report on dietary supplements containing ephedra makes urgent call for research to develop dose guidelines, safety warnings
5. Posters highlight water, energy and other natural resource research
6. Hunting illusive signs of natural selection
7. University of Arizona licenses patent for natural fungicide
8. Improving crops without genetic modification natural variation holds the key
9. Using statistics to decipher secrets of natural mutation
10. New designed paclitaxel analog kills more cancer cells than natural product
11. After natural disasters, the risk of infection, epidemics from dead bodies is negligible

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/31/2016)...  Genomics firm Nabsys has completed a financial  restructuring ... , M.D., who returned to the company in October ... team, including Chief Technology Officer, John Oliver , ... and Vice President of Software and Informatics, Michael ... Dr. Bready served as CEO of Nabsys from 2005-2014 ...
(Date:3/21/2016)... 22, 2016 Unique technology ... for superior security   Xura, ... of secure digital communications services, today announced it is ... offer enterprise customers, particularly those in the Financial Services ... voice authentication within a mobile app, alongside, and in ...
(Date:3/14/2016)... 14, 2016 NXTD ) ("NXT-ID" or ... market, announces the airing of a new series of commercials ... of March 21 st .  The commercials will air on ... Squawk on the Street show. --> NXTD ) ... mobile commerce market, announces the airing of a new series ...
Breaking Biology News(10 mins):
(Date:5/25/2016)... ... May 25, 2016 , ... Founder of the Fitzmaurice ... surgery and surgery of the hand by the National Board of Physicians and ... above and beyond in his pursuit of providing the most comprehensive, effective treatment ...
(Date:5/25/2016)... (PRWEB) , ... May 25, 2016 , ... Scientists at ... line options being tried for mesothelioma may be hampering the research that could lead ... research. Click here to read it now. , The team evaluated 98 ...
(Date:5/25/2016)... ... May 25, 2016 , ... Lady had been battling arthritis ... cruciate ligament in her left knee. Lady’s owner Hannah sought the help of Dr ... veterinary surgeon, to repair her cruciate ligament and help with the pain of Lady’s ...
(Date:5/24/2016)... ... 2016 , ... Cell therapies for a range of serious ... at Worcester Polytechnic Institute (WPI) that yielded a newly patented method of converting ... novel method, developed by WPI faculty members Raymond Page, PhD, professor of practice ...
Breaking Biology Technology:
Cached News: