HOME >> BIOLOGY >> NEWS
Drug breaks for HIV-infected individuals may put certain immune cells at risk

DALLAS May 2, 2002 Disruption of antiretroviral therapy by patients infected with HIV may be putting certain T-cells in their bloodstream at greater risk for infection with the deadly virus if it is allowed to rebound, a study in the May 2 issue of the journal Nature concludes.

Patients whose viral counts have fallen to nearly imperceptible levels sometimes interrupt antiviral therapy temporarily, re-starting treatment if viral levels rebound. Called structured therapy interruption, these drug breaks can increase the number of certain HIV-fighting T-cells, called CD8 T-cells, in the blood. Another type of T-cell, CD4, also plays an important role in fighting HIV.

Using data collected at UT Southwestern Medical Center at Dallas, researchers have found that, even though CD8 cells increase in number with interruption of therapy, HIV-specific CD4 cells appear to be particularly prone to infection by the virus during treatment interruption. Infections of CD4 cells hasten their destruction and help spread the disease to other cells in the body.

In time, as the patients immune system is progressively weakened, this can give rise to full-blown AIDS, researchers say.

The patient can begin taking antiviral drugs to control the virus again, although this therapy is not a cure. It is unknown how long it takes for the body to regenerate these HIV-specific CD4 cells once the bodys supply has become infected, or even if regeneration occurs with re-initiation of anti-viral treatment.

During the treatment interruption, although HIV-fighting CD8 cells increase, HIV-specific CD4 cells also become infected if the virus is allowed to rebound, said Dr. Joseph Casazza, a co-author and assistant professor of infectious disease at UT Southwestern. In effect, by taking a drug break, you could be robbing Peter to pay Paul.


'"/>

Contact: Mindy Baxter
melinda.baxter@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
1-May-2002


Page: 1

Related biology news :

1. Cigarette smoke causes breaks in DNA and defects to a cells chromosomes, Pitt study finds
2. New model explains why costly insect outbreaks hard to predict
3. Spruce bark beetle outbreaks examined at Alaska Symposium
4. Ebola outbreaks are simultaneous mini-epidemics
5. Mustard-root map breaks new ground tracking gene expression
6. $51 million research facility, classroom complex breaks ground at UH
7. Some 400 fragile regions of genome more vulnerable to evolutionary breaks
8. System failure to blame for Walkerton, North Battleford outbreaks, says U of T study
9. As Vitamin B-6 levels go down, numbers of DNA strand breaks go up
10. Checkpoint protein blocks chromosome breaks at fragile sites
11. Insect infestation models may shed light on insect and disease outbreaks

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... , Apr. 11, 2017 Research and ... Market 2017-2021" report to their offering. ... The global eye tracking market to grow at a ... report, Global Eye Tracking Market 2017-2021, has been prepared based on ... covers the market landscape and its growth prospects over the coming ...
(Date:4/6/2017)... April 6, 2017 Forecasts by ... Document Readers, by End-Use (Transportation & Logistics, Government & ... Gas & Fossil Generation Facility, Nuclear Power), Industrial, Retail, ... Are you looking for a definitive report ... ...
(Date:4/5/2017)... 4, 2017 KEY FINDINGS The ... at a CAGR of 25.76% during the forecast period ... primary factor for the growth of the stem cell ... MARKET INSIGHTS The global stem cell market ... and geography. The stem cell market of the product ...
Breaking Biology News(10 mins):
(Date:6/23/2017)... ... June 23, 2017 , ... ... of a redesigned, easier-to-navigate website for all six of their healthcare job ... nurses, dentists, pharmacists, physical and occupational therapists, and biotechnicians, DocCafe.com and the ...
(Date:6/22/2017)... (PRWEB) , ... June 22, 2017 , ... ... taking over the allergy specialists DST Diagnostische Systeme & Technologien GmbH, thereby expanding ... know someone who suffers from hay fever, urticaria, asthma, atopic eczema or a ...
(Date:6/22/2017)... ... June 22, 2017 , ... ... the release of Limfinity® version 6.5, a content-packed update to the Limfinity® framework. ... gain a larger and more diverse base of customers among labs and other ...
(Date:6/20/2017)... , June 20, 2017  Kibow Biotech Inc., a ... announce the issuance of a new patent covering a ... by the U.S. Patent and Trademark Office on May ... of the Buzz of Bio award in 2014 in ... to developing non-drug approaches to chronic disease. Renadylâ„¢, the ...
Breaking Biology Technology:
Cached News: