HOME >> BIOLOGY >> NEWS
Drug breaks for HIV-infected individuals may put certain immune cells at risk

DALLAS May 2, 2002 Disruption of antiretroviral therapy by patients infected with HIV may be putting certain T-cells in their bloodstream at greater risk for infection with the deadly virus if it is allowed to rebound, a study in the May 2 issue of the journal Nature concludes.

Patients whose viral counts have fallen to nearly imperceptible levels sometimes interrupt antiviral therapy temporarily, re-starting treatment if viral levels rebound. Called structured therapy interruption, these drug breaks can increase the number of certain HIV-fighting T-cells, called CD8 T-cells, in the blood. Another type of T-cell, CD4, also plays an important role in fighting HIV.

Using data collected at UT Southwestern Medical Center at Dallas, researchers have found that, even though CD8 cells increase in number with interruption of therapy, HIV-specific CD4 cells appear to be particularly prone to infection by the virus during treatment interruption. Infections of CD4 cells hasten their destruction and help spread the disease to other cells in the body.

In time, as the patients immune system is progressively weakened, this can give rise to full-blown AIDS, researchers say.

The patient can begin taking antiviral drugs to control the virus again, although this therapy is not a cure. It is unknown how long it takes for the body to regenerate these HIV-specific CD4 cells once the bodys supply has become infected, or even if regeneration occurs with re-initiation of anti-viral treatment.

During the treatment interruption, although HIV-fighting CD8 cells increase, HIV-specific CD4 cells also become infected if the virus is allowed to rebound, said Dr. Joseph Casazza, a co-author and assistant professor of infectious disease at UT Southwestern. In effect, by taking a drug break, you could be robbing Peter to pay Paul.


'"/>

Contact: Mindy Baxter
melinda.baxter@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
1-May-2002


Page: 1

Related biology news :

1. Cigarette smoke causes breaks in DNA and defects to a cells chromosomes, Pitt study finds
2. New model explains why costly insect outbreaks hard to predict
3. Spruce bark beetle outbreaks examined at Alaska Symposium
4. Ebola outbreaks are simultaneous mini-epidemics
5. Mustard-root map breaks new ground tracking gene expression
6. $51 million research facility, classroom complex breaks ground at UH
7. Some 400 fragile regions of genome more vulnerable to evolutionary breaks
8. System failure to blame for Walkerton, North Battleford outbreaks, says U of T study
9. As Vitamin B-6 levels go down, numbers of DNA strand breaks go up
10. Checkpoint protein blocks chromosome breaks at fragile sites
11. Insect infestation models may shed light on insect and disease outbreaks

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/16/2017)... N.J. , May 16, 2017  Veratad Technologies, ... provider of online age and identity verification solutions, announced ... K(NO)W Identity Conference 2017, May 15 thru May 17, ... Regan Building and International Trade Center. ... the globe and in today,s quickly evolving digital world, ...
(Date:5/6/2017)... May 5, 2017 RAM Group ... a new breakthrough in biometric authentication based on ... mechanical properties to perform biometric authentication. These new sensors ... material created by Ram Group and its partners. This ... transportation, supply chains and security. Ram Group is ...
(Date:4/19/2017)... New York , April 19, 2017 ... competitive, as its vendor landscape is marked by the ... the market is however held by five major players ... Safran. Together these companies accounted for nearly 61% of ... of the leading companies in the global military biometrics ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... For the second time ... US2020 STEM Mentoring Award. Representatives of the FirstHand program travelled to Washington, D.C. ... US2020. , US2020’s mission is to change the trajectory of STEM education in ...
(Date:10/10/2017)... SANTA CRUZ, Calif. , Oct. 10, 2017 /PRNewswire/ ... SBIR grant from the NIH to develop RealSeq®-SC (Single ... preparation kit for profiling small RNAs (including microRNAs) from ... Cell Analysis Program highlights the need to accelerate development ... "New techniques for ...
(Date:10/9/2017)... SAN DIEGO , Oct. 9, 2017 /PRNewswire/ ... a biological mechanism by which its ProCell stem ... of critical limb ischemia.  The Company, demonstrated that ... the amount of limbs saved as compared to ... of the molecule HGF resulted in reduction of ...
(Date:10/9/2017)... , ... October 09, 2017 , ... ... four-tiered line of medical marijuana products targeting the needs of consumers who are ... of Kindred takes place in Phoenix, Arizona. , As operators of two successful ...
Breaking Biology Technology:
Cached News: