HOME >> BIOLOGY >> NEWS
Drug combo effective in advanced breast cancer

A pair of studies at UCLA's Jonsson Cancer Center taking laboratory science to the patient bedside found that combining the molecularly targeted therapy Herceptin with a specific chemotherapy combination resulted in significant tumor response rates and longer relapse-free periods in women with an aggressive form of advanced breast cancer.

The results of the studies, the first done on cell lines in the laboratory and the second translated into more than 120 patients in two Phase II clinical trials, appear Tuesday (May 18) in the peer-reviewed Journal of the National Cancer Institute.

In an accompanying editorial, Dr. George W. Sledge, Jr., co-director of the Breast Cancer Program at the Indiana University School of Medicine, called the studies "an impressive example of translational research at its best."

"Designing a sequential series of experiments, both laboratory and clinical, that lead intentionally to proof-of-concept adjuvant (Phase III) trials is all too rare," Sledge states in the editorial. "But, as (UCLA researchers) remind us, it is not impossible."

Jonsson Cancer Center researchers first tested drug combinations in the laboratory with the goal of translating their results into patients with HER2/neu amplification, a genetic alternation found in 20 to 25 percent of patients that leads to an aggressive form of breast cancer.

Lead by researchers Dr. Dennis Slamon and Dr. Mark Pegram, the laboratory studies analyzed Herceptin for interaction with nine chemotherapy drugs commonly used to treat breast cancer. Researchers found that the chemotherapy agents Taxotere, Navelbine, Cyclophosphamide and the platinum salts Cisplatin and Carboplatin increased the activity of Herceptin in lab models with HER2/neu amplification. In other words, Herceptin and the chemotherapy agents each made the other more effective, a synergistic effect. The laboratory studies pointed researchers to the optimum chemotherapy combination, which
'"/>

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles
18-May-2004


Page: 1 2 3

Related biology news :

1. Avastin-Tarceva combo provides one-two punch against lung cancer
2. Toxin combo common in fish appears capable of impairing motor skills
3. ENBREL combo therapy inhibits joint damage progression, offers significant RA symptom relief
4. Rum and coke combo far worse on the brain, study shows
5. International study findings link acne-like rash to effectiveness of new targeted cancer treatment
6. Endurance exercise found to be equally effective as diuretics in improving cardiac health
7. Purdue yeast makes ethanol from agricultural waste more effectively
8. Scientists learn how adjuvant makes vaccines effective
9. Super-effective jumping gene created
10. Data show investigational antibiotic safe, effective in preventing travelers diarrhea
11. Mexican farmers effectively cultivate phenotypic diversity in maize

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/21/2020)... ... May 19, 2020 , ... ... provider of operations management solutions, today introduced BioMed to their award-winning computerized ... platform for connecting the people and systems around biomedical engineering to better ...
(Date:5/21/2020)... ... ... Law Enforcement has always been a highly stressful career – serving to protect, ... and women put them constantly in harm’s way both from the criminal element as ... to face very high daily stress. Now, COVID-19 introduces another even greater degree of ...
(Date:5/15/2020)... ... May 15, 2020 , ... The National Institutes of Health ... firm based in Frederick, Maryland and Tysons Corner, Virginia, to provide patent legal services ... a another in the field of chemistry. The firm is one of nine firms ...
Breaking Biology News(10 mins):
(Date:7/10/2020)... Mass. (PRWEB) , ... July 09, 2020 , ... ... approaches to cell therapy, today announced the hiring of Allen R. Nissenson, M.D., ... team and oversee the clinical development of Sentien’s lead product, SBI-101. Dr. ...
(Date:7/1/2020)... ... June 29, 2020 , ... MedShift , a leading ... despite many obstacles created as a result of COVID-19. As a provider at ... medical practices and medical manufacturers by expanding access to device offerings, technology services, ...
(Date:6/28/2020)... ... 25, 2020 , ... The Indoor Lab, a leading provider of sensor solutions ... all types to ensure cleanliness, distancing and occupancy with its patent pending WipeAway™ technology ... business will provide a health performance index system that scores all aspects of compliance ...
(Date:6/28/2020)... SPRING, Md. (PRWEB) , ... June 26, 2020 ... ... leading trade association representing security solutions providers, today announced its strong opposition to ... , The bill would impose a blanket ban on most federal use of ...
Breaking Biology Technology:
Cached News: