HOME >> BIOLOGY >> NEWS
Drug-naive schizophrenia: The dopamine connection

Since the introduction of chlorpromazine in psychiatry in 1952, all antipsychotic drugs with proven efficacy have been dopamine (DA) D2 receptor antagonists. It has been suggested that positive schizophrenic symptoms (such as hallucinations) are associated with increased subcortical DA neurotransmission, and negative and cognitive symptoms with impaired mesocortical DA function. Studies on striatal D2 receptor densities in drug-naive schizophrenic patients have indicated that deviation in D2 density is larger among patients vs. controls, and although some patients have markedly elevated D2 levels, the D2 densities do not differ substantially at group level. Although DA neurotransmission in basal ganglia may be more important for motor functions rather than for emotions and behavioral symptoms, D2 binding studies have previously concentrated in the striatum, because there have been no suitable in vivo -ligands available for measuring extrastriatal D2 receptor binding. The aim of this study was to test the hypothesis that extrastriatal D2/3 density in temporal and cingulate cortex is lower among drug naive schizophrenic patients when compared with matched controls.

The results indicate that in drug-naive schizophrenic patients the extrastriatal dopamine D2/3 receptor density is markedly decreased. The authors also observed negative correlations between D2/3 receptor density and age among controls, and between D2/3 density and negative and general psychopathological symptom scores among patients. These results support the previous hypothesis on dysfunction of mesocortical dopamine function behind the cognitive and negative symptoms in schizophrenia.


'"/>

Contact: Aimee Midei
molecularpsychiatry@mednet.ucla.edu
310-206-6739
Molecular Psychiatry
12-May-2003


Page: 1

Related biology news :

1. Cognitive therapy for schizophrenia: Hope for those whom drugs havent helped
2. Vollum scientists find new form of dopamine transmission
3. How amphetamine affects the dopamine transporter
4. The dopamine receptor D1 gene and ADHD: A piece of the genetic puzzle?
5. Jefferson scientists show neural stem cells can become dopamine-making brain cells in laboratory
6. Molecule awakens and maintains neural connections
7. The Mediterranean connection: ecological effects of El Nio in the Northern hemisphere
8. OHSU researchers discover possible connection between infant hormone exposure, obesity
9. Gene essential for development of normal brain connections resulting from sensory input discovered
10. K-State professor examines connections between food, culture and psychology in new book
11. New study clarifies connection of brain and heart failure

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Drug naive schizophrenia The dopamine connection

(Date:7/30/2015)... , July 30, 2015 Cellecta, Inc., ... gene function analysis and biomarker discovery, announced the ... Knockout Library targeting all human protein coding genes. ... "knock out" a gene,s function. Cellecta,s new Human ... throughput screening tool so that researchers can investigate ...
(Date:7/23/2015)... , July 23, 2015 Research and ... of the "Global Outlook of the Biometrics ... The global biometrics market is ... and commercial applications owing to the uptake of ... a transformation that enhances the growth of biometrics ...
(Date:7/20/2015)... DENVER , July 20, 2015  Acuity ... Mobility Report: The Convergence of Commerce and Privacy" ... billion mobile biometric apps will be downloaded to ... users. The mobile biometrics market is projected to ... app revenue during the seven-year forecast period.    ...
Breaking Biology News(10 mins):CELLECTA, INC. Announces Launch of Human Whole Genome CRISPR Knockout Library 2Global Outlook of the Biometrics Industry 2015 2Global Outlook of the Biometrics Industry 2015 3Biometrics on Smart Mobile Devices to Redefine Digital Identity with 12.9 Billion Biometric App Downloads between 2014 and 2020 2
(Date:7/30/2015)... 30, 2015 AACC welcomed thousands of ... AACC Annual Meeting & Clinical Lab Expo in ... The meeting showcased revolutionary advancements in clinical testing ... healthcare providers to diagnose patients quickly and accurately ... As of Wednesday, July 29, ...
(Date:7/30/2015)... ... July 30, 2015 , ... ... Francois Vieillard as Sales & Marketing Director. , With more than 25 ... be responsible for reinforcing Tronics’ business development activities worldwide. He brings to the ...
(Date:7/30/2015)... 30, 2015 According to a ... Molecular Modeling, PB/PK, PKPD, Trial Design, Toxicity Prediction, In-house, ... Clinical Trial), by End Users - Global Forecast to ... to reach USD 2,107.99 million by 2020 from USD ... Browse more than 75 ...
(Date:7/30/2015)... July 30, 2015   Aratana Therapeutics, Inc ... company focused on the licensing, development and commercialization ... announced that its strategic partner VetStem Biopharma, Inc. ... study of AT-016, an adipose-derived allogeneic stem cell ... of osteoarthritis pain in dogs. The ...
Breaking Biology Technology:Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 2Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 3Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 4Tronics appoints Francois Vieillard as Sales and Marketing Director 2Biosimulation Market Worth 2,107.99 Million USD by 2020 2Biosimulation Market Worth 2,107.99 Million USD by 2020 3Biosimulation Market Worth 2,107.99 Million USD by 2020 4Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 2Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 3Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 4Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 5
Cached News: