HOME >> BIOLOGY >> NEWS
Drug prevents chemotherapy-induced hearing loss, study finds

PORTLAND, Ore. -- A drug used to treat people with Tylenol poisoning prevents hearing loss caused by a common chemotherapy drug, an Oregon Health & Science University study reports.

The study published in the journal Hearing Research found that rats treated with N-acetylcysteine, or NAC, did not suffer from platinum-induced ototoxicity, or hearing loss, caused by a widely used chemotherapeutic agent known as cisplatin.

Cisplatin, or CDDP, is a platinum-based compound used in chemotherapy for head and neck cancer. But it causes progressive, irreversible hearing loss, reducing patients' quality of life and forcing doctors to use lower, less-effective doses of the drug.

"It affects about a third of all children with cancer in the United States, not just those with brain tumors," said study co-author Edward Neuwelt, M.D., professor of neurology and neurological surgery, OHSU School of Medicine, and the Portland Veterans Affairs Medical Center. He also directs OHSU's Blood-Brain Barrier Program. "It's a big problem."

The study's lead author, D. Thomas Dickey, D.V.M., research instructor in neurology, OHSU School of Medicine, called ototoxicity "one of the main dose-limiting factors in giving cisplatin."

"Cisplatin is given a lot. It's been around a long time, and it's very effective. But it's very toxic," Dickey said.

Cisplatin is administered intravenously to slow or stop the growth of cancer cells. In addition to head and neck cancers, the drug is used to treat cervical carcinoma, lung cancer, neurologic cancers and a wide variety of other malignancies. But it injures hair cells of the cochlea, the spiral, inner-ear structure containing thousands of tiny hair cells that vibrate in response to sound waves.

"These hair cells are often destroyed," Dickey said. "It starts at the outer edge and moves in. Once it happens, it's progressive -- it gets worse and worse -- and it's permanent."

Hearing aids aren't as
'"/>

Contact: Jonathan Modie
modiej@ohsu.edu
503-494-8231
Oregon Health & Science University
20-Jul-2004


Page: 1 2 3

Related biology news :

1. Lack of immune system protein prevents lupus-like condition in mice
2. Combination of gene therapy and gene silencing prevents neurodegenerative disease
3. Pacifying bacteria prevents lethal post-op infections
4. Investigational cancer drug prevents abnormal brain growth, reverses seizures in lab mice
5. Hopkins researchers discover how nitric oxide prevents blood vessel inflammation
6. Injection prevents blinding blood vessel growth in mice
7. Tiny protein prevents disease-related cell death
8. Smart mathematical model prevents the spread of swine fever
9. Aspirin prevents polyps in colon cancer patients
10. Twin sister mechanism prevents formation of genetic mutations
11. Vaccine prevents stroke in rats

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/17/2019)... ... July 17, 2019 , ... ... and its acclaimed pediatric urologists are among the professionals honored in U.S. ... signifies excellence among the country’s pediatric healthcare landscape. , Georgia Urology’s wholly-owned ...
(Date:7/10/2019)... ... July 10, 2019 , ... Inference ... and service organizations, today announced its role in Pizza Hut Australia’s digital ... of its franchisees. A key part of this initiative is implementation of an ...
(Date:6/27/2019)... ... 2019 , ... Lighting designers from integrated design firm LPA recently ... for creating both engaging and energy efficient lighting systems. , The lighting for the ... San Diego, California earned an IES Illumination Award of Merit in the Energy and ...
Breaking Biology News(10 mins):
(Date:7/11/2019)... ... ... At the most recent stem cell training course in Las ... R3 Heroes Program. The Veterans included individuals and families from all over the US, ... a military Veteran, teacher or first responder to receive a regenerative therapy at a ...
(Date:6/18/2019)... YORK and SOMERSET, N.J. (PRWEB) , ... June ... ... Catalent Biologics, today announced that they have entered into an agreement for production ... product candidates, IC-100 for the treatment of rhodopsin-mediated autosomal dominant retinitis pigmentosa (RHO-adRP) ...
(Date:6/11/2019)... ... June 10, 2019 , ... DeepDyve ... of its scientific journals to DeepDyve’s rental service for peer-reviewed journals. , ... library of more than 20 million articles, sourced from more than 15,000 journals. ...
(Date:5/31/2019)... ... ... For many years, the primary forms of cancer treatment have been chemotherapy, ... immuno-oncology have led to the advent of Chimeric Antigen Receptor T (CAR T) cell ... as “CARs”. The CAR enables the final product to produce chemicals in the hopes ...
Breaking Biology Technology:
Cached News: