HOME >> BIOLOGY >> NEWS
Drug prevents chemotherapy-induced hearing loss, study finds

PORTLAND, Ore. -- A drug used to treat people with Tylenol poisoning prevents hearing loss caused by a common chemotherapy drug, an Oregon Health & Science University study reports.

The study published in the journal Hearing Research found that rats treated with N-acetylcysteine, or NAC, did not suffer from platinum-induced ototoxicity, or hearing loss, caused by a widely used chemotherapeutic agent known as cisplatin.

Cisplatin, or CDDP, is a platinum-based compound used in chemotherapy for head and neck cancer. But it causes progressive, irreversible hearing loss, reducing patients' quality of life and forcing doctors to use lower, less-effective doses of the drug.

"It affects about a third of all children with cancer in the United States, not just those with brain tumors," said study co-author Edward Neuwelt, M.D., professor of neurology and neurological surgery, OHSU School of Medicine, and the Portland Veterans Affairs Medical Center. He also directs OHSU's Blood-Brain Barrier Program. "It's a big problem."

The study's lead author, D. Thomas Dickey, D.V.M., research instructor in neurology, OHSU School of Medicine, called ototoxicity "one of the main dose-limiting factors in giving cisplatin."

"Cisplatin is given a lot. It's been around a long time, and it's very effective. But it's very toxic," Dickey said.

Cisplatin is administered intravenously to slow or stop the growth of cancer cells. In addition to head and neck cancers, the drug is used to treat cervical carcinoma, lung cancer, neurologic cancers and a wide variety of other malignancies. But it injures hair cells of the cochlea, the spiral, inner-ear structure containing thousands of tiny hair cells that vibrate in response to sound waves.

"These hair cells are often destroyed," Dickey said. "It starts at the outer edge and moves in. Once it happens, it's progressive -- it gets worse and worse -- and it's permanent."

Hearing aids aren't as
'"/>

Contact: Jonathan Modie
modiej@ohsu.edu
503-494-8231
Oregon Health & Science University
20-Jul-2004


Page: 1 2 3

Related biology news :

1. Lack of immune system protein prevents lupus-like condition in mice
2. Combination of gene therapy and gene silencing prevents neurodegenerative disease
3. Pacifying bacteria prevents lethal post-op infections
4. Investigational cancer drug prevents abnormal brain growth, reverses seizures in lab mice
5. Hopkins researchers discover how nitric oxide prevents blood vessel inflammation
6. Injection prevents blinding blood vessel growth in mice
7. Tiny protein prevents disease-related cell death
8. Smart mathematical model prevents the spread of swine fever
9. Aspirin prevents polyps in colon cancer patients
10. Twin sister mechanism prevents formation of genetic mutations
11. Vaccine prevents stroke in rats

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/26/2020)... ... August 25, 2020 , ... Mitotech S.A, ... with Essex Bio-Technology, a bio-pharmaceutical company specializing in Ophthalmology and Dermatology, announced ... SkQ1 ophthalmic solution in patients with moderate to severe Dry Eye Disease ...
(Date:8/21/2020)... , ... August 19, 2020 , ... ... LLC and SalivaBio LLC, businesses dedicated to Salivary Bioscience for more than twenty ... recently published book by Springer, " Salivary Bioscience: Foundations of Interdisciplinary Saliva Research ...
(Date:8/7/2020)... ... August 06, 2020 , ... ... pleased to announce that Eric Chen and Jessica Wong have joined the company’s ... & Strategy, respectively. , Eric Chen heads development efforts for Alucio’s flagship product, ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... BINGHAM FARMS, Mich. (PRWEB) , ... August 12, ... ... International Consulting Group, Inc. (EMMA International), a global leader in FDA compliance ... ranking of the nation’s fastest-growing private companies. The list represents a unique look ...
(Date:8/3/2020)... ... 03, 2020 , ... Introducing Ardent Animal Health – MediVet Biologics rebrands company ... Known as MediVet Biologics since its formation in 2016, the company is relaunching ... Health will build on its base of innovative therapies for osteoarthritis and cancer. ...
(Date:7/31/2020)... ... July 29, 2020 , ... Diversified Technologies, Inc. has introduced ... configured to drive Klystrons, TWTs, IOTs, and magnetrons. , DTI Radar Transmitter ... in a push-pull configuration; yielding fast fall time for a capacitive load. These ...
(Date:7/31/2020)... , ... July 29, 2020 , ... eSource has long ... This webinar will cover the history of eSource, the reasons it did not take ... to wearables, to site source, the industry is moving towards capturing data electronically for ...
Breaking Biology Technology:
Cached News: