HOME >> BIOLOGY >> NEWS
Drug resistance found to vary by ethnicity

New Orleans, March 25, 2001 -- A genetic mutation affecting resistance to chemotherapy occurs more frequently in some ethnic groups than in others according to a new study.

Researchers found that African and African American populations included more individuals with the drug-resistant gene than Caucasian or Asian populations. This might help explain why some people of African descent respond poorly to chemotherapy. The research will be presented March 25 at the annual meeting of the American Association for Cancer Research in New Orleans.

"We now know that the genetic influence on drug resistance is not the same throughout the whole population," says Howard L. McLeod, Pharm.D., associate professor of medicine, of pharmacology and molecular biology and of genetics at Washington University School of Medicine in St. Louis. "Because of this work, we can try to solve the problem."

McLeod, who led the international team of researchers from his previous position at the University of Aberdeen in the United Kingdom, specializes in pharmacogenetics, an emerging research field. Margaret-Mary Ameyaw, M.D., Ph.D., of the University of Aberdeen is the studys first author and will join the Washington University faculty later this year.

The mutation studied by McLeod and his colleagues changes production of a protein called P-glycoprotein, or PGP, a molecular pump that rids cells of drugs. When working correctly, PGP pumps chemotherapeutic drugs out of tumors, allowing the tumor cells to survive. This response is known as drug resistance. The genetic mutation means the PGP pump stops working, allowing drugs to enter and kill tumor cells.

PGP also rids cells of many other medications, such as HIV protease inhibitors and drugs used to control high blood pressure and prevent failure of kidney transplants.

Working with collaborators in five countries, McLeod and his colleagues did DNA tests on blood samples from 1,280 people from 10 ethnic populations. Th
'"/>

Contact: Anne Enright Shepherd
shepherda@msnotes.wustl.edu
314-286-0119
Washington University School of Medicine
24-Mar-2001


Page: 1 2

Related biology news :

1. Master of antimalarial resistance
2. Anthrax enzyme images reveal secrets of antibiotic resistance, suggest new drug design
3. Evolvability could be a driving force in drug resistance
4. Insecticide resistance: A constraint on evolutionary change
5. New drug shows promise against Gleevec resistance in mice
6. New milestones on the path to conquering HIV drug resistance (AIDS)
7. Study investigates breast cancer resistance to tamoxifen and possible way to reverse it
8. Antibiotic resistance risk from triclosan questioned
9. Cancer drug resistance research leads to possible therapeutic target for Alzheimers disease
10. Researchers string together players in pesticide resistance orchestra
11. Chicken litter harbors agents that generate antibiotic multi-resistance, according to UGA study

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/5/2020)... ... , ... Regenative Labs has received approval from the Centers for Medicare & ... first Wharton’s jelly allografts to be assigned a Q code and be approved for ... Wharton’s jelly allograft product to be recognized as a 361 HCT/P by CMS regulated ...
(Date:7/18/2020)... ... July 16, 2020 , ... A study has been published ... Neoasis™ active noise control device to attenuate typical noises in a simulated neonatal ... the alarm sounds from patient monitors, ventilators and other bedside devices that would ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com ... a biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European ... J Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... FARMS, Mich. (PRWEB) , ... August 12, 2020 ... ... Consulting Group, Inc. (EMMA International), a global leader in FDA compliance consulting ... of the nation’s fastest-growing private companies. The list represents a unique look at ...
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... collection, today announced Jim Corrigan, President and CEO has been named one of ... broad cross-section of industry sectors, PharmaVoice 100 honorees are selected based on how ...
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is ... $3950. With 50 million stem cells total, patients may choose which extremities they would ... for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. ... drive one or two switches in a push-pull configuration; yielding fast fall time ...
Breaking Biology Technology:
Cached News: