Drug stops blinding blood vessel growth in mice

--Prevents Damage from Diabetic Retinopathy, Macular Degeneration

Scientists at Johns Hopkins and Novartis Ltd. Pharmaceuticals, in partnership with Novartis' CIBA Vision eye care unit, have identified a drug that completely stops the growth of abnormal blood vessels on or beneath the retinas of laboratory mice.

Results of the mouse studies, published in the June issue of the American Journal of Pathology, could mean that people at risk for blindness associated with macular degeneration or diabetes may one day be able to pop a pill to prevent blinding blood vessel growth. Vessels that grow abnormally in the eyes can leak fluid or blood, causing rapid and severe vision loss. Such growth is the hallmark of diabetic retinopathy and age-related macular degeneration, the leading causes of blindness in young and old people, respectively, in developed countries.

Human trials of the drug, called PKC 412, could begin early next year, says Peter A. Campochiaro, M.D., senior author of the study and a professor of ophthalmology and neuroscience at Hopkins.

"This is the first drug I've seen that has a knock-your-socks-off kind of effect," Campochiaro says. "Previous drug studies have only halted growth of abnormal vessels by roughly 50 percent, but this medication appears to stop it completely in three mouse models. Remarkably, the drug can be given orally, the preferred method of drug delivery in people. If these animal models are predictive, the drug should work in people."

In diabetics, high blood sugar through a cascade of events can lead to damage to normal retinal blood vessels and a decrease in the supply of oxygen and nutrients. The retina calls for back up by releasing vascular endothelial growth factor (VEGF), a substance that stimulates new blood vessels to grow to try to compensate. However, the back-up blood vessels generally are faulty; they leak, bleed and encourage scar tissue th

Contact: Karen Infeld
Johns Hopkins Medical Institutions

Page: 1 2 3

Related biology news :

1. MIT research that stops pain of needle jabs gets FDA approval
2. Protein stops blood-vessel growth, holds promise as cancer therapy
3. How DNA copying enzyme stops the presses for repair synthesizing enzyme
4. New class of antibiotics stops pathogens in their genetic tracks
5. Catnip stops termites dead in their tracks
6. Experimental therapy stops allergic reactions in mice
7. Mutation on Y chromosome stops sperm production
8. Rainforest birds keep dying out long after logging stops
9. New clues to hereditary blinding disease found
10. Injection prevents blinding blood vessel growth in mice
11. Comprehensive set of vision genes discovered: Identification could help in diagnosing and treating blinding diseases

Post Your Comments:

(Date:7/1/2020)... ... July 01, 2020 , ... Catalent, a global ... of Teva-Takeda Pharmaceuticals’ packaging facility in Minakuchi, located in the Shiga prefecture of ... located in Kakegawa, the new 60,000-square-foot facility will provide customers with flexible clinical ...
(Date:6/25/2020)... ... June 24, 2020 , ... eClinical Solutions ... data services that accelerate drug development, is collaborating with Karyopharm Therapeutics (Nasdaq: ... hospitalized patients with severe COVID-19. This is the first study of an XPO1 ...
(Date:6/23/2020)... ... June 23, 2020 , ... ... pleased to announce the next event in a series of TOPIQ webinars, which ... TOPIQ series of webinars was developed in response to social distancing measures that ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... ... eSource has long been touted as the solution to high data management ... reasons it did not take off as quickly as people initially expected, and where ... towards capturing data electronically for clinical trials and then repurposing it for downstream analysis, ...
(Date:7/18/2020)... ... ... “We are thrilled to deliver this new technology to the industry” said Matt Hundt, ... market and we were pleased that the IFT jury recognized that.” reFRESH™ couples the ... natural way to extend the shelf life and improve the safety of perishable foods ...
(Date:7/10/2020)... , ... July 09, 2020 , ... ... 1-phenyl-2-thiourea (PTU) is commonly used to suppress pigment formation in zebrafish embryos, maintaining ... research team led by Dr MA has been using the zebrafish model to ...
(Date:7/1/2020)... GREEN, Ohio (PRWEB) , ... June 29, 2020 ... ... that offers access to competitively procured purchasing contracts to its membership, recently named ... to provide TIPS members with the opportunity to purchase ergonomic seating, cafeteria tables, ...
Breaking Biology Technology:
Cached News: