HOME >> BIOLOGY >> NEWS
Drug wrecks the power plants of cancer cells

Researchers have identified a compound that selectively kills tumor cells by destroying their metabolic power plants. The researchers believe that the compound, code-named F16, could serve as a model for a targeted chemotherapy with low toxicity.

In an article published in the July 2002 issue of the journal Cancer Cell, researchers led by Howard Hughes Medical Institute senior investigator Philip Leder at Harvard Medical School reported that they screened 16,000 small molecules to look for compounds that would have a favorable effect on transgenic mouse cells engineered to overexpress the cancer-causing gene neu. The human counterpart of neu, which is called HER-2, has been implicated in 20-30 percent of human breast cancers, and is linked with a poor prognosis for breast cancer treatment.

"Because neu or its human analog are such important elements in breast cancer, we decided to carry out these experiments to identify metabolic pathways that might collaborate with HER-2 or neu in the development of malignancy," said Leder.

In the experiments, the paper's lead author, HHMI associate Valeria R. Fantin, introduced the neu gene into mouse mammary epithelial cells. Mouse mammary epithelial cells that overexpress neu bear some of the characteristics of human breast tumors. Fantin then tested each of the 16,000 molecules to see how it affected the growth of the transgenic and normal mouse cells. These studies showed that F16 selectively inhibited the growth of the neu-overexpressing cells, but not the normal cells.

Additional studies indicated that F16 also inhibited the proliferation of a number of mouse cancer-cell lines that were derived in Leder's laboratory and a panel of human breast cancer cell lines. The researchers found that F16 prevented the formation of tumors that would normally occur when '"/>

Contact: Jim Keeley
keeleyj@hhmi.org
301-208-6560
Howard Hughes Medical Institute
16-Jul-2002


Page: 1 2 3

Related biology news :

1. Ecowar looming with sunken wartime wrecks
2. Green, leafy spinach may soon power cellphones and laptops
3. Wastewater could treat itself, power city
4. ASU researchers demonstrate new technique that improves the power of atomic force micrscopy
5. Coordinating power of circadian rhythms keeps estrus and pregnancy on track
6. FDA approves VYTORIN, first and only to powerfully reduce LDL cholesterol through dual inhibition
7. Spanish scientists develop powerful tool for exploration and integration of biological information
8. Volcanic soils yield new clues about the emergence of powerful chiefdoms in Hawaii
9. Motion that powers sperm provides key to unravelling rare genetic disorder
10. Ethanol to power the future of hydrogen fuel cells
11. A shocking surprise: High voltage + rats = ozone, reopens power-line debate

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/16/2019)... ... ... SFC Fluidics, Inc. (SFC) has partnered with two companies, Diabeloop SA ... awarded to SFC Fluidics in 2018 by JDRF. , JDRF is sponsoring this project ... with type 1 diabetes (T1D). By accelerating the development of a next-generation miniaturized and ...
(Date:5/9/2019)... ... May 09, 2019 , ... Akadeum Life Sciences today announced ... its microbubble technology. Unlike magnetic-based products, microbubbles use buoyancy to gently separate cells ... who participated in an early access program has been very encouraging and has ...
(Date:5/8/2019)... QUEBEC CITY (PRWEB) , ... May 08, 2019 ... ... new small sensor, with a diameter of 200 microns and a lead-in fiber ... again establishing the new industry standard and positioning itself as the world leader ...
Breaking Biology News(10 mins):
(Date:4/16/2019)... ... April 16, 2019 , ... ... their project partner, the U.S. Army Center for Environmental Health Research (USACEHR), with ... Combined In-Licensing/Out-Licensing.” , Blue Sources, a veteran-owned company located at the Frederick Innovative ...
(Date:4/12/2019)... ... April 12, 2019 , ... An upcoming ... will educate about innovative tools and devices being used to enhance cognitive skills. ... information. , This segment of Advancements will focus on Sound for Life, a ...
(Date:4/9/2019)... , ... April 09, 2019 , ... ... focused on increasing the capacity of life sciences organizations to accelerate innovation and ... Assurance platform in the past 12 months. , USDM’s Cloud Assurance ...
(Date:4/8/2019)... ... April 08, 2019 , ... CallTower, ... today the launch of their app integration solution, CT Cloud Unite. CT ... applications while using CT Cloud Voice and Skype for Business solutions. This robust ...
Breaking Biology Technology:
Cached News: