HOME >> BIOLOGY >> NEWS
Drugs limit deadly side effects of graft-versus-host disease

ANN ARBOR, MI V A new class of anti-cancer drugs, currently being tested in human clinical trials, reduces the severity of graft-versus-host disease or GVHD a common and often deadly complication of life-saving bone marrow transplants without suppressing the immune response required to kill lingering cancer cells.

Scientists at the University of Michigan's Comprehensive Cancer Center are the first to study the effect of these drugs, called HDAC inhibitors, in laboratory mice with cancer after the mice received a bone marrow transplant. Results of the U-M study were published online in this week's early edition of the Proceedings of the National Academy of Sciences.

Other studies have shown that high doses of HDAC inhibitors can be an effective anti-tumor agent in mice and humans. Now, U-M scientists have found that low doses of the same drugs have a powerful anti-inflammatory effect. This prevents the production of proteins called inflammatory cytokines, which cause the extensive cell damage seen in GVHD patients. "What's so exciting is that HDAC inhibitors already have been tested as a chemotherapeutic agent in people," says co-author James L.M. Ferrara, M.D., director of the U-M's Blood and Marrow Transplant Program and a professor of internal medicine and pediatrics in the U-M Medical School. "They have relatively little toxicity and the doses required to generate an anti-inflammatory effect are 50- to 100-fold lower than doses needed to kill cancer cells."

If HDAC inhibitors work as well in cancer patients as they did in mice in the U-M study, they could reduce the risk of death, hospitalization and serious side effects associated with bone marrow transplants used to treat leukemia and other related cancers.

More than 5,000 Americans receive allogeneic bone marrow transplants annually. An allogeneic donor is someone other than the patient or the patient's identical twin. Between 500 to 1,000 Americans die from gr
'"/>

Contact: Sally Pobojewski
pobo@umich.edu
734-615-6912
University of Michigan Health System
27-Feb-2004


Page: 1 2 3 4 5

Related biology news :

1. Drugs, electronics, and green catalysts: The chemical year in review
2. Drugs from sea study finds sponge health link to bacteria
3. Drugs on tap
4. Discovery Of A Molecule That Controls Bile Acids May Lead To New Cholesterol Drugs
5. UT Southwestern Researchers Find Way To Control Gene Activity, Opening Way For Cancer Drugs
6. New Findings On Receptor Regulation May Lead To Better Drugs For Diabetes
7. NASA Research Helps Map Protein Structures -- Key In The Development Of New Disease-Fighting Drugs
8. 15 Drugs, Dyes And Other Chemicals Newly Listed As Known Or Likely Human Carcinogens
9. Cholesterol Lowering Drugs Stall Disease Progression In People With Below-Average Blood Cholesterol Level
10. Some AIDS Patients May Show Resistance To Sulfa Drugs
11. Researchers Discover Existing Drugs May Prevent Enlarged Hearts

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/5/2018)... ... December 04, 2018 , ... Slone Partners, North America’s leading ... Michael Mercer at Karius, Inc. as Chief Commercial Officer. Now responsible for developing, ... Karius' headquarters in Redwood City, California and report to CEO Mickey Kertesz Ph.D. ...
(Date:12/5/2018)... Texas (PRWEB) , ... December 04, 2018 , ... ... supplier, has announced the much-anticipated launch of their 100-liter (26 gallon) SAFEthread Drum. ... SAFEthread Drum in 2017, which brought a much-needed modern redesign to the ...
(Date:12/5/2018)... ... December 04, 2018 , ... ... expertise and existing IP in the development of innovative solutions for which high-speed ... into diverse systems from microfluidics to industrial machinery and instrumentation, allowing partner companies ...
Breaking Biology News(10 mins):
(Date:11/26/2018)... , ... November 26, 2018 , ... ... backed by Siemens Healthineers and Omphalos Venture Partners (Virtual Radiologic founders) among other ... Meeting from Nov. 25-29 at McCormick Place in Chicago. The company is proud ...
(Date:11/20/2018)... ... November 19, 2018 , ... Patients with missing teeth in Sandy ... from Dr. Dan Myers at THE DENTIST Centers without a referral. Dr. Myers ... for the last 20 years. He now offers skilled dental care in two practice ...
(Date:11/20/2018)... ... November 20, 2018 , ... Dr. Steven White and Dr. Brad Haines invite ... in Cornelius, NC. This common infection, left untreated, can be destructive to oral and ... training and certification in laser dentistry, Drs. White and Haines are uniquely qualified to ...
(Date:11/13/2018)... ... 13, 2018 , ... Renowned Honolulu veterinarian, Dr. Patrick Leadbeater, has begun offering ... Dr. Leadbeater, of Kahala Pet Hospital on Oahu, is a skilled surgeon ... to the island of Kauai on an almost weekly basis to perform surgery at ...
Breaking Biology Technology:
Cached News: