Drunken Fruit Flies Reveal Molecular Pathway Regulating Sensitivity To Alcohol

came more sensitive, or more inebriated, than their brethren. More importantly, however, when the researchers examined how the amnesiac gene normally functions within the fruit fly's neural system, they determined that it regulates the cyclic AMP (cAMP) pathway, a signal transduction cascade that scientists at the Gallo Center have long known was affected by alcohol through studies in human cells. This discovery fit with a previous finding, namely that amnesiac is believed to encode a molecule that stimulates cAMP production.

The scientists thus deduced that the fruit flies missing the amnesiac gene had reduced cAMP production, and that this action caused greater intoxication. To test their hypothesis, they treated the mutant amnesiac flies with agents that increased cAMP levels and were able to reverse the alcohol sensitivity. The finding made a giant leap from an isolated gene in fruit flies to an entire molecular pathway previously observed in animal and human cell cultures.

"This was an exciting discovery," said Heberlein. "We've known cAMP was involved in the brain's response to alcohol, but we haven't known what role it plays in causing the behavioral effects associated with intoxication. Our study demonstrates that proper regulation of the cAMP signaling pathway is central to establishing ethanol sensitivity in Drosophila."

The finding does not suggest that the amnesiac mutation exists in humans, nor that any one gene affects sensitivity to alcohol in higher animals. The significance, said Heberlein "is that we have found a pathway that modulates the response to alcohol."

"Our next step, she said, "is to identify more genes in fruit flies associated with alcohol behaviors and to see if we can find homologous, or similarly acting, genes in higher organisms, including mice and humans." Ultimately, of course, if these genes do exist in humans the researchers hope to find that they are linked to alcoholic behaviors.

Given how strikingly simi

Contact: Jennifer O'Brien
(415) 476-2557
University of California - San Francisco

Page: 1 2 3

Related biology news :

1. Drunken worms reveal a genetic basis of alcohol response
2. Fruits offer powerful protection from skin cancer
3. Fruit odors lure some flies to evolve into new species
4. Fruit fly pheromone receptor first ever discovered linked to specific sexual behavior
5. Fruit consumption related to increased risk of Parkinsons?
6. Fruit fly cells reveal Hedgehogs secrets
7. Fruit flies unlock Methuselahs secrets
8. Fruit fly model could explain how mosquitoes carry malaria: new drugs and vaccines on the horizon
9. Fruit flys genome sequence finished in record time: Physical maps are the key to accuracy
10. Research Bears Fruit, And Patents
11. Compounds From Fruits, Vegetables And Grains Slow The Growth Of Human Tumor Cells

Post Your Comments:

(Date:7/4/2020)... ... July 03, 2020 , ... Aesthetics Biomedical (ABM), a leading ... for not only the products and treatments developed, but also the dedicated team ... All the brands built by ABM have received several honors already for 2020, ...
(Date:7/2/2020)... ... July 02, 2020 , ... ... B.V. (MBS) has announced a publication detailing the use of its revolutionary ... polymerase chain reaction (RT-PCR) in 16 minutes. The article, titled "Ultra-fast one-step ...
(Date:7/1/2020)... (PRWEB) , ... July 01, 2020 , ... ... building awareness and solutions for glioblastoma—the most common and aggressive adult brain cancer—announced ... Haile, JD, PhD. Senior Fellows are charged with supporting the organization’s initiatives and ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... SCOTTSDALE, Ariz. (PRWEB) , ... July 29, 2020 , ... ... cell joint injections for only $3950. With 50 million stem cells total, patients may ... well stem cell therapy works for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 ...
(Date:7/31/2020)... ... July 29, 2020 , ... Diversified ... systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. , ... one or two switches in a push-pull configuration; yielding fast fall time for ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... the leading global provider of advanced delivery technologies, development, and manufacturing solutions for ... they have entered into a strategic partnership whereby Catalent will provide support for ...
(Date:7/31/2020)... ... 29, 2020 , ... The SDX® Respiratory Gating System ... has reached its 20th anniversary of worldwide use. Introduced in the US over ... including University of Pennsylvania, University of Michigan, University of Maryland, University of California ...
Breaking Biology Technology:
Cached News: