HOME >> BIOLOGY >> NEWS
Drunken worms reveal a genetic basis of alcohol response

Since one of the basic risk factors for alcoholism is a tolerance to alcohol, researchers have long sought to understand the genetic differences among people that affect their sensitivity to alcohol. So far, scientists have met with little success.

However, by exposing populations of the roundworm C. elegans to alcohol and pinpointing subtle genetic differences among strains that respond differently, researchers have identified one gene that affects alcohol sensitivity.

In an article in the June 10, 2004, issue of Neuron, Andrew Davies and his colleagues describe their findings that subtle differences between worm strains in the gene for a brain protein called NPR-1 explains differences in the worms' alcohol sensitivity.

The researchers chose the worm as their subject because there is evidence that alcohol has effects on worm behavior. Although the mechanisms that mediate alcohol response in humans or other animals are not well understood, most human neuronal proteins have worm versions and it seems likely that at least some of the mechanisms are shared. Additionally, the worm has been the subject of massive genetic study by scientists, and genetically distinct strains are available from around the world.

In their experiments, Davies and his colleagues exposed two wild strains of worms -- one from England and one from Hawaii to alcohol and compared how they showed "acute tolerance" when first exposed to ethanol. The researchers used alcohol concentrations comparable to those that cause intoxication in humans.

The researchers measured the worms' responses by how much slower their movement became after exposure. The Hawaiian worms showed a more dramatic recovery from initial intoxication than did the English worms.

Genetic analyses of the two strains led to a subtle difference between the strains in the gene for NPR-1. The genetic difference, their experiments showed, caused p
'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
9-Jun-2004


Page: 1 2

Related biology news :

1. Drunken Fruit Flies Reveal Molecular Pathway Regulating Sensitivity To Alcohol
2. Convulsions in worms mimic epileptic seizures
3. Heartless worms hold clues to cardiac arrhythmias, sudden death
4. Whale carcass yields bone-devouring worms
5. Oxygen sensing in worms may hold key to healthy blood pressure in humans
6. Researchers discover how worms noses sense oxygen
7. Study in worms shows how genes linked to complexity in animals
8. Two worms are better than one
9. Cows resistance to worms is genetically determined
10. Alien earthworms changing ecology of Northeast forests
11. Amorous worms reveal effects of Chernobyl

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/30/2017)... -- Trends, opportunities and forecast in this market to ... AFIS, iris recognition, facial recognition, hand geometry, vein recognition, ... industry (government and law enforcement, commercial and retail, health ... and by region ( North America , ... , and the Rest of the World) ...
(Date:3/28/2017)... 2017 The report "Video Surveillance ... Servers, Storage Devices), Software (Video Analytics, VMS), and Service ... Forecast to 2022", published by MarketsandMarkets, the market was ... projected to reach USD 75.64 Billion by 2022, at ... base year considered for the study is 2016 and ...
(Date:3/24/2017)... The Controller General of Immigration from Maldives Mr. Mohamed Anwar ... prestigious international IAIR Award for the most innovative high security ePassport and ... ... Maldives Immigration Controller General, Mr. Mohamed ... the right) have received the IAIR award for the "Most innovative high ...
Breaking Biology News(10 mins):
(Date:8/15/2017)... ... ... Kapstone Medical is proud to announce that it has reached ... inventors develop and safeguard their latest innovations. The company has grown from a ... clients in the United States and around the world. , Company Founder and ...
(Date:8/15/2017)... ... August 15, 2017 , ... Pittcon is pleased ... analytical and scientific instruments. This year’s symposium, organized by the Pittcon 2018 program ... for Bioanalytical Applications.” This dynamic presentation will discuss novel ionization processes, high throughput ...
(Date:8/15/2017)... Wisconsin (PRWEB) , ... August 15, 2017 , ... ... a new family of 6” modular downlights designed to stay tightly sealed and ... including areas where damp and wet location listings just aren't enough, such as: ...
(Date:8/15/2017)... (PRWEB) , ... August 15, 2017 , ... ... and is threatened by various biotic and abiotic factors. During this educational webinar, ... history of coffee, as well as gain a better understanding of how genomics ...
Breaking Biology Technology:
Cached News: