HOME >> BIOLOGY >> NEWS
Drunken worms reveal a genetic basis of alcohol response

Since one of the basic risk factors for alcoholism is a tolerance to alcohol, researchers have long sought to understand the genetic differences among people that affect their sensitivity to alcohol. So far, scientists have met with little success.

However, by exposing populations of the roundworm C. elegans to alcohol and pinpointing subtle genetic differences among strains that respond differently, researchers have identified one gene that affects alcohol sensitivity.

In an article in the June 10, 2004, issue of Neuron, Andrew Davies and his colleagues describe their findings that subtle differences between worm strains in the gene for a brain protein called NPR-1 explains differences in the worms' alcohol sensitivity.

The researchers chose the worm as their subject because there is evidence that alcohol has effects on worm behavior. Although the mechanisms that mediate alcohol response in humans or other animals are not well understood, most human neuronal proteins have worm versions and it seems likely that at least some of the mechanisms are shared. Additionally, the worm has been the subject of massive genetic study by scientists, and genetically distinct strains are available from around the world.

In their experiments, Davies and his colleagues exposed two wild strains of worms -- one from England and one from Hawaii to alcohol and compared how they showed "acute tolerance" when first exposed to ethanol. The researchers used alcohol concentrations comparable to those that cause intoxication in humans.

The researchers measured the worms' responses by how much slower their movement became after exposure. The Hawaiian worms showed a more dramatic recovery from initial intoxication than did the English worms.

Genetic analyses of the two strains led to a subtle difference between the strains in the gene for NPR-1. The genetic difference, their experiments showed, caused p
'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
9-Jun-2004


Page: 1 2

Related biology news :

1. Drunken Fruit Flies Reveal Molecular Pathway Regulating Sensitivity To Alcohol
2. Convulsions in worms mimic epileptic seizures
3. Heartless worms hold clues to cardiac arrhythmias, sudden death
4. Whale carcass yields bone-devouring worms
5. Oxygen sensing in worms may hold key to healthy blood pressure in humans
6. Researchers discover how worms noses sense oxygen
7. Study in worms shows how genes linked to complexity in animals
8. Two worms are better than one
9. Cows resistance to worms is genetically determined
10. Alien earthworms changing ecology of Northeast forests
11. Amorous worms reveal effects of Chernobyl

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/25/2016)...   Unisys Corporation (NYSE: UIS ) today announced ... International Airport, New York City , to help ... to enter the United States using passports ... pilot testing of the system at Dulles last year. The ... during January 2016. --> pilot testing of the ...
(Date:1/22/2016)... http://www.researchandmarkets.com/research/p74whf/global_biometrics ) ... "Global Biometrics Market in Retail Sector 2016-2020" ... --> http://www.researchandmarkets.com/research/p74whf/global_biometrics ) has announced the ... in Retail Sector 2016-2020" report to ... and Markets ( http://www.researchandmarkets.com/research/p74whf/global_biometrics ) has announced ...
(Date:1/20/2016)... Minn. , Jan. 20, 2016   MedNet ... supports the entire spectrum of clinical research, is pleased ... 2015. MedNet,s significant achievements are the result of the ... iMedNet eClinical , it,s comprehensive, easy-to-use ... --> --> Key MedNet growth achievements ...
Breaking Biology News(10 mins):
(Date:2/10/2016)... 10, 2016  Allergan plc (NYSE: AGN ) ... Brent Saunders , Allergan,s CEO and President, will be ... session at the RBC Capital Markets Healthcare Conference on ... The New York Palace Hotel in New ... live and can be accessed on Allergan,s Investor Relations ...
(Date:2/10/2016)... ... February 10, 2016 , ... HOLLOWAY AMERICA, ... Pharmaceutical Engineering (ISPE) Rocky Mountain Chapter 21st Annual Vendor Exhibition on Thursday, February ... than 100 tables for its annual event, which will run from 3:00 p.m. ...
(Date:2/10/2016)... San Mateo, CA (PRWEB) , ... February 10, ... ... Registry of Multiplex Testing (PROMPT), a research registry built on the secure online ... in September 2014. More than 1,600 participants have joined the PROMPT study, which ...
(Date:2/10/2016)... ... February 10, 2016 , ... Cenna Bioscience Inc., an emerging biopharmaceutical company focused ... announced today it has been selected to present at the Cavendish Global Health Impact ... Florida. The purpose of the Forum is to help family offices and foundations ...
Breaking Biology Technology:
Cached News: