HOME >> BIOLOGY >> NEWS
Drunken worms reveal a genetic basis of alcohol response

Since one of the basic risk factors for alcoholism is a tolerance to alcohol, researchers have long sought to understand the genetic differences among people that affect their sensitivity to alcohol. So far, scientists have met with little success.

However, by exposing populations of the roundworm C. elegans to alcohol and pinpointing subtle genetic differences among strains that respond differently, researchers have identified one gene that affects alcohol sensitivity.

In an article in the June 10, 2004, issue of Neuron, Andrew Davies and his colleagues describe their findings that subtle differences between worm strains in the gene for a brain protein called NPR-1 explains differences in the worms' alcohol sensitivity.

The researchers chose the worm as their subject because there is evidence that alcohol has effects on worm behavior. Although the mechanisms that mediate alcohol response in humans or other animals are not well understood, most human neuronal proteins have worm versions and it seems likely that at least some of the mechanisms are shared. Additionally, the worm has been the subject of massive genetic study by scientists, and genetically distinct strains are available from around the world.

In their experiments, Davies and his colleagues exposed two wild strains of worms -- one from England and one from Hawaii to alcohol and compared how they showed "acute tolerance" when first exposed to ethanol. The researchers used alcohol concentrations comparable to those that cause intoxication in humans.

The researchers measured the worms' responses by how much slower their movement became after exposure. The Hawaiian worms showed a more dramatic recovery from initial intoxication than did the English worms.

Genetic analyses of the two strains led to a subtle difference between the strains in the gene for NPR-1. The genetic difference, their experiments showed, caused p
'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
9-Jun-2004


Page: 1 2

Related biology news :

1. Drunken Fruit Flies Reveal Molecular Pathway Regulating Sensitivity To Alcohol
2. Convulsions in worms mimic epileptic seizures
3. Heartless worms hold clues to cardiac arrhythmias, sudden death
4. Whale carcass yields bone-devouring worms
5. Oxygen sensing in worms may hold key to healthy blood pressure in humans
6. Researchers discover how worms noses sense oxygen
7. Study in worms shows how genes linked to complexity in animals
8. Two worms are better than one
9. Cows resistance to worms is genetically determined
10. Alien earthworms changing ecology of Northeast forests
11. Amorous worms reveal effects of Chernobyl

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Drunken worms reveal genetic basis alcohol response

(Date:3/24/2015)... DUBLIN , Mar. 24, 2015 Research and ... addition of the "Global Iris Recognition Market 2015-2019" ... forecast the Global Iris Recognition market to grow at ... This report covers the present scenario and ... for the period 2015-2019. To calculate the market size, ...
(Date:3/23/2015)... YORK , March 23, 2015   HOYOS ... property management company, today announced that the Company will ... for both enterprise and consumers at Connect:ID on March ... HOYOS Labs will highlight the IEEE Biometric ... TM ; and enterprise access control system. BOPS ...
(Date:3/20/2015)... , March 20, 2015 NXT-ID, Inc. (NASDAQ: ... authentication company focused on the growing mobile commerce market, ... is one of the products featured in 2015 "I ... at 11:00 PM EST on the DIY Network.   ... Las Vegas , site of the 2015 ...
Breaking Biology News(10 mins):Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 2NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 3
(Date:3/26/2015)... Houston, Texas (PRWEB) March 26, 2015 ... assist technologies, and Transonic, a supplier of precision transit-time ... board that will greatly improve the efficiency of the ... will enable LVAD patients to experience greater mobility and ... embedded with the miniature flow board, will draw 1/6th ...
(Date:3/26/2015)... March 26, 2015 Ale Gicqueau, Founder ... Director of Clinical Affairs at Align Technology, on “ ... the upcoming ACRP 2015 Global Conference and Exhibition on ... Utah. , During the poster presentation, Ale Gicqueau ... and running a Postmarket Registry, the requirements and resources ...
(Date:3/25/2015)... is one of the most attractive in the emerging ... a growing economy and increasing government investment in healthcare, ... Russian market is set to grow at twice the ... around 10-15% annually reaching an approximate market value of ... Green Cross provides total healthcare solutions that ...
(Date:3/25/2015)... Diagnostics Inc. ("SQI" or the "Company") (TSX-V: SQD; OTCQX: ... with certain shareholders representing approximately 45% of the outstanding ... certain matters including the appointment of auditors at its ... 2015 (the "Meeting") it intends to adjourn the Meeting ... when the Meeting reconvenes. The Meeting will be reconvened ...
Breaking Biology Technology:LVAD patients to have greater mobility and peace of mind through Transonic and ReliantHeart’s True Flow collaboration for the HeartAssist5® 2LVAD patients to have greater mobility and peace of mind through Transonic and ReliantHeart’s True Flow collaboration for the HeartAssist5® 3Clinovo Presents at ACRP 2015 in Salt Lake City, Utah on April 25th-28th 2Clinovo Presents at ACRP 2015 in Salt Lake City, Utah on April 25th-28th 3SQI Diagnostics Inc. Announces New Nominees to SQI Diagnostics Board and Adjournment of Meeting 2SQI Diagnostics Inc. Announces New Nominees to SQI Diagnostics Board and Adjournment of Meeting 3SQI Diagnostics Inc. Announces New Nominees to SQI Diagnostics Board and Adjournment of Meeting 4SQI Diagnostics Inc. Announces New Nominees to SQI Diagnostics Board and Adjournment of Meeting 5
Cached News: