HOME >> BIOLOGY >> NEWS
Duke Researchers Discover Candidate Susceptibility Gene For Autoimmune Disease

DURHAM, N.C. -- Researchers at Duke University Medical Center have identified a gene in mice that, when malfunctioning, causes a joint-destroying, arthritis-like disease in the animals. The discovery may provide a clue to the underlying genetic defects that can lead some people's immune systems to attack their own bodies, the Duke researchers say.

Led by Dr. Perry Blackshear of the Howard Hughes Medical Institute at Duke University, the research team published their results in the May issue of the journal Immunity. Gregory Taylor and Ester Carballo of Blackshear's lab were the lead authors of the paper. Blackshear also is a professor of biochemistry and medicine at Duke medical center.

To date, doctors have not identified any specific genes for autoimmune diseases such as rheumatoid arthritis, although many researchers believe there may be several genes that, when defective, predispose people to develop autoimmune disorders.

The Duke researchers made the discovery while trying to understand the role of a gene of unknown function that seemed to be involved in the action of insulin, a hormone involved in diabetes. Instead, they found they had actually located what may be a key gene involved in autoimmune diseases such as arthritis and dermatitis.

"This research is a perfect example of how research in one area can often lead to an understanding in an apparently unrelated field," Blackshear said. "We were studying factors in the body that are influenced by insulin, which regulates sugar levels in the bloodstream, and instead, discovered a gene that appears to regulate the inflammatory response."

Working with Duke University Arthritis Center researchers Dr. Bart Haynes and Dr. Dhavalkumar Patel, and with Dr. Gary Gilkeson, Blackshear's team determined that the animals had characteristic antibodies against their own tissues that represent an inflammatory autoimmune response. By comparing their mice with other anima
'"/>

Contact: Karyn Hede George
georg016@mc.duke.edu
919-660-1301
Duke University
14-May-1996


Page: 1 2 3

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/5/2020)... ... , ... Regenative Labs has received approval from the Centers for Medicare & ... first Wharton’s jelly allografts to be assigned a Q code and be approved for ... Wharton’s jelly allograft product to be recognized as a 361 HCT/P by CMS regulated ...
(Date:7/18/2020)... ... July 16, 2020 , ... A study has been published ... Neoasis™ active noise control device to attenuate typical noises in a simulated neonatal ... the alarm sounds from patient monitors, ventilators and other bedside devices that would ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com ... a biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European ... J Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... FARMS, Mich. (PRWEB) , ... August 12, 2020 ... ... Consulting Group, Inc. (EMMA International), a global leader in FDA compliance consulting ... of the nation’s fastest-growing private companies. The list represents a unique look at ...
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... collection, today announced Jim Corrigan, President and CEO has been named one of ... broad cross-section of industry sectors, PharmaVoice 100 honorees are selected based on how ...
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is ... $3950. With 50 million stem cells total, patients may choose which extremities they would ... for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. ... drive one or two switches in a push-pull configuration; yielding fast fall time ...
Breaking Biology Technology:
Cached News: