HOME >> BIOLOGY >> NEWS
Duke Researchers Discover Candidate Susceptibility Gene For Autoimmune Disease

ls that had similar clinical signs, the researchers hypothesized the animals were producing too much of a potent inflammatory protein called tumor necrosis factor alpha (TNFa).
To test their idea, the researchers injected the TTP-deficient animals with an antibody that neutralizes TNFa. In a dramatic and almost complete reversal, all signs of disease completely disappeared.

The findings support preliminary results of human clinical trials being conducted at Duke and other research institutions of an experimental treatment for rheumatoid arthritis (RA) that also uses antibodies to TNFa, Blackshear said. Such studies have shown antibodies to TNFa can significantly reduce the symptoms of RA in patients.

"We know that TNFa is involved in many human inflammatory diseases including autoimmune disorders and septic shock," Blackshear said. "This finding provides insight into a new gene that appears to regulate TNFa. It is possible that defects in this gene may cause people to be susceptible to developing autoimmune diseases."

The corresponding gene has been identified in people, and Blackshear's group will soon begin a study to see if mutations in the gene correlate with autoimmune disease in people.

"The TTP-deficient mouse is an exciting new model of arthritis," said Haynes, chairman of medicine at Duke and director of the Duke University Arthritis Center. "It also provides important new information about the types of genes that can cause arthritis."

In addition to using the animal model to understand the autoimmune response, Blackshear will continue studies to determine how TTP is involved in the insulin response.

"Right now we really don't have a good handle on what TTP is doing, although there are hints it is involved in gene regulation," Blackshear said. "Our next step will be to determine if it is involved in synthesis or degradation of TNF_ and then move forward to our original question of how TTP i
'"/>

Contact: Karyn Hede George
georg016@mc.duke.edu
919-660-1301
Duke University
14-May-1996


Page: 1 2 3

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
(Date:7/30/2014)... tended her eggs until they hatched 4.5 years later, ... the open-access journal PLOS ONE by Bruce ... , Octopuses typically have a single reproductive period during ... of their fertilized eggs until they hatch. Shallow-water octopuses ... months, but little is known about the brooding of ...
(Date:7/30/2014)... effects of climate change on the world,s animal ... factors, according to a new paper by a ... of Queensland, and other organizations. The authors claim ... the point when it comes to climate change. ... scientists focus on the "direct" threats of changing ...
(Date:7/30/2014)... Board of the Entomological Society of America (ESA) has ... The election as a Fellow acknowledges outstanding contributions to ... teaching, extension, or administration. The following Fellows will be ... -- which will be held November 16-19, 2014 in ... is a professor with the Department of Plant, Soil ...
Breaking Biology News(10 mins):Deep-sea octopus has longest-known egg-brooding period 2Conservation scientists asking wrong questions on climate change impacts on wildlife 2Entomological Society of America recognizes 2014 fellows 2Entomological Society of America recognizes 2014 fellows 3Entomological Society of America recognizes 2014 fellows 4Entomological Society of America recognizes 2014 fellows 5Entomological Society of America recognizes 2014 fellows 6Entomological Society of America recognizes 2014 fellows 7Entomological Society of America recognizes 2014 fellows 8Entomological Society of America recognizes 2014 fellows 9Entomological Society of America recognizes 2014 fellows 10Entomological Society of America recognizes 2014 fellows 11Entomological Society of America recognizes 2014 fellows 12Entomological Society of America recognizes 2014 fellows 13Entomological Society of America recognizes 2014 fellows 14Entomological Society of America recognizes 2014 fellows 15Entomological Society of America recognizes 2014 fellows 16Entomological Society of America recognizes 2014 fellows 17
(Date:7/31/2014)... July 31, 2014 CollabRx, Inc. (NASDAQ: ... therapeutic decision-making in oncology, today announced that it will ... to discuss the Company's financial results for the first ... about the business in the current fiscal year. , ... on Thursday, August 14, 2014, at 5 p.m. EDT ...
(Date:7/31/2014)... Francisco, Calif. (PRWEB) July 31, 2014 ... newly diagnosed patients with an overview of the disease ... management of drug side effects, as well as updates ... “We’re grateful to Dr. Sandy Srinivas for organizing this ... survivor of kidney cancer. “Sandy and her colleagues have ...
(Date:7/31/2014)... “Rapid technological advances will spread a ... unemployment, depressing American consumer spending and further shrinking ... 22—we need automated manufacturing if we are to ... economist and corporate relocation expert Dr. Ron Pollina ... States for 2014, co-published with the American Economic ...
(Date:7/31/2014)... Boston’s Adult Stem Cell Technology Center, LLC ( ... cell biotechnologies. Currently the company holds seven recently ... applications currently under examination by the U.S. Patent and ... the most vexing problems in adult stem cell biology ... difficult to identify; and they have been difficult to ...
Breaking Biology Technology:CollabRx, Inc. Schedules First Quarter Fiscal Year 2015 Financial Conference Call and Business Update 2ITRA Global Affiliate’s Pollina Corporate Top 10 Pro-Business States Minimize the Impact of Automation on Middle Class and Unemployment 2ITRA Global Affiliate’s Pollina Corporate Top 10 Pro-Business States Minimize the Impact of Automation on Middle Class and Unemployment 3ITRA Global Affiliate’s Pollina Corporate Top 10 Pro-Business States Minimize the Impact of Automation on Middle Class and Unemployment 4The Adult Stem Cell Technology Center, LLC Launches A Marketing Campaign To License Adult Stem Cell Biotechnologies 2The Adult Stem Cell Technology Center, LLC Launches A Marketing Campaign To License Adult Stem Cell Biotechnologies 3
Cached News: