HOME >> BIOLOGY >> NEWS
Duke Study Helps Explain How Cells Divvy Up Genes During Reproduction

DURHAM, N.C. -- For centuries, scientists have watched in wonder at the microscopic world of the cell. In many ways a self-contained world, it runs much as a tiny metropolis with production plants, energy generators, and transport systems to move its products around efficiently. Now researchers are beginning to sort out just how cells get all this work done.

In a report published in the Aug. 21 issue of the journal Science, Duke cell biologist Sharyn Endow and postdoctoral fellow Kimberly Waligora said they have for the first time been able to take apart a molecular motor, put it back together, make it run in reverse, and then mutate the motor and make it run the other way.

The motor they worked on is a key component of the machinery that divides up the genetic material during a special type of cell division that makes sperm and eggs. When this machinery malfunctions, chromosomes, the carriers of genetic material, can become jumbled and the wrong number of chromosomes can end up in each egg. This can result in infertility or syndromes such as Down's, in which a child has an extra copy of chromosome 21.

The scientists hope these experimental models will give clues to why some women have multiple miscarriages, and why, as women age, more of their eggs have the wrong number of chromosomes, increasing the odds of Down's syndrome and other birth defects.

Endow discovered the motor, called Ncd (nonclaret disjunctional), in fruit flies, but similar motors operate in all animals, including people, she said.

"Our hope is that by understanding how these molecular motors operate, we will be able to identify why sometimes things go wrong in the reproductive process," Endow said. "Right now it is very difficult to do these experiments with animals more advanced than flies because they make eggs internally. That makes it difficult to observe the process. But using flies, in which the process is thought to be
'"/>

Contact: Karyn Hede George
Georg016@mc.duke.edu
(919) 684-4148
Duke University Medical Center
20-Aug-1998


Page: 1 2 3

Related biology news :

1. Study: Emission of smog ingredients from trees is increasing rapidly
2. Study explores gene transfer to modify underlying course of Alzheimers disease
3. Study reveals why eyes in some paintings seem to follow viewers
4. Study by Israeli scientists provides insight on DNA code
5. Study reveals first genetic step necessary for prostate cancer growth
6. Study of flu patients reveals virus outsmarting key drug
7. Study in Science reveals recreational fishing takes big bite of ocean catch
8. Study suggests cell-cycle triggers might be cancer drug targets
9. Study narrows search for genes placing men at increased risk for prostate cancer
10. Study links high carbohydrate diet to increased breast cancer risk
11. Study explains spatial orientation differences between sexes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/1/2016)... 1, 2016  Today, the first day of American ... to develop a first of its kind workplace health ... Watson. In the first application of Watson ... IBM ), and Welltok will create a new offering ... cognitive analytics, delivered on Welltok,s health optimization platform. The ...
(Date:1/25/2016)... BLUE BELL, Pa. , Jan. 25, 2016   Unisys ... facial recognition system at John F. Kennedy (JFK) International Airport, ... and Border Protection (CBP) identify imposters attempting to enter ... or do not belong to them. pilot testing ... rolled out initially at three terminals at JFK during January 2016. ...
(Date:1/21/2016)... , January 21, 2016 ... to a new market research report "Emotion Detection and ... Others), Software Tools (Facial Expression, Voice Recognition and ... - Global forecast to 2020", published by MarketsandMarkets, ... expected to reach USD 22.65 Billion by 2020, ...
Breaking Biology News(10 mins):
(Date:2/3/2016)... , Feb. 3, 2016  Discovery Laboratories, ... focused on developing aerosolized KL4 surfactant therapies for ... Directors has approved an inducement award as a ... , its newly appointed President and Chief Executive ... Compensation Committee on February 1, 2016 and granted ...
(Date:2/3/2016)... 2016 New Jersey Health Foundation (NJHF) has ... for researchers in New Jersey ... demonstrates exciting potential.   James M. ... New Jersey Health Foundation Research Grant Program ... institutions— Princeton University, Rutgers University, Rowan University and ...
(Date:2/3/2016)... ... February 03, 2016 , ... Resilinc released online ... analyzes nearly 750 unique supply chain notifications and alerts generated by its ... chain risk management practitioners subscribe to the EventWatch service to receive early warnings ...
(Date:2/3/2016)... ... February 03, 2016 , ... Data Sciences ... solutions focused on social housing of small animal models in research studies. ... ² , DSI’s HD-S11 implant has evolved to allow researchers to simultaneously measure ...
Breaking Biology Technology:
Cached News: