HOME >> BIOLOGY >> NEWS
Duke Study Helps Explain How Cells Divvy Up Genes During Reproduction

DURHAM, N.C. -- For centuries, scientists have watched in wonder at the microscopic world of the cell. In many ways a self-contained world, it runs much as a tiny metropolis with production plants, energy generators, and transport systems to move its products around efficiently. Now researchers are beginning to sort out just how cells get all this work done.

In a report published in the Aug. 21 issue of the journal Science, Duke cell biologist Sharyn Endow and postdoctoral fellow Kimberly Waligora said they have for the first time been able to take apart a molecular motor, put it back together, make it run in reverse, and then mutate the motor and make it run the other way.

The motor they worked on is a key component of the machinery that divides up the genetic material during a special type of cell division that makes sperm and eggs. When this machinery malfunctions, chromosomes, the carriers of genetic material, can become jumbled and the wrong number of chromosomes can end up in each egg. This can result in infertility or syndromes such as Down's, in which a child has an extra copy of chromosome 21.

The scientists hope these experimental models will give clues to why some women have multiple miscarriages, and why, as women age, more of their eggs have the wrong number of chromosomes, increasing the odds of Down's syndrome and other birth defects.

Endow discovered the motor, called Ncd (nonclaret disjunctional), in fruit flies, but similar motors operate in all animals, including people, she said.

"Our hope is that by understanding how these molecular motors operate, we will be able to identify why sometimes things go wrong in the reproductive process," Endow said. "Right now it is very difficult to do these experiments with animals more advanced than flies because they make eggs internally. That makes it difficult to observe the process. But using flies, in which the process is thought to be
'"/>

Contact: Karyn Hede George
Georg016@mc.duke.edu
(919) 684-4148
Duke University Medical Center
20-Aug-1998


Page: 1 2 3

Related biology news :

1. Study: Emission of smog ingredients from trees is increasing rapidly
2. Study explores gene transfer to modify underlying course of Alzheimers disease
3. Study reveals why eyes in some paintings seem to follow viewers
4. Study by Israeli scientists provides insight on DNA code
5. Study reveals first genetic step necessary for prostate cancer growth
6. Study of flu patients reveals virus outsmarting key drug
7. Study in Science reveals recreational fishing takes big bite of ocean catch
8. Study suggests cell-cycle triggers might be cancer drug targets
9. Study narrows search for genes placing men at increased risk for prostate cancer
10. Study links high carbohydrate diet to increased breast cancer risk
11. Study explains spatial orientation differences between sexes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/4/2017)... YORK , April 4, 2017   EyeLock ... today announced that the United States Patent and Trademark ... patent broadly covers the linking of an iris image ... same transaction) and represents the company,s 45 th ... latest patent is very timely given the multi-modal biometric ...
(Date:3/30/2017)... , March 30, 2017  On April 6-7, 2017, ... the Genome hackathon at Microsoft,s headquarters in ... competition will focus on developing health and wellness apps ... Hack the Genome is the first hackathon ... The world,s largest companies in the genomics, tech and ...
(Date:3/30/2017)... March 30, 2017 Trends, opportunities and forecast ... behavioral), by technology (fingerprint, AFIS, iris recognition, facial recognition, ... others), by end use industry (government and law enforcement, ... and banking, and others), and by region ( ... Asia Pacific , and the Rest ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... first-ever genomics analysis platform specifically designed for life science researchers to analyze ... pioneering researcher Rosalind Franklin, who made a major contribution to the discovery ...
(Date:10/11/2017)... Alto, CA, USA (PRWEB) , ... October 11, 2017 , ... ... set to take place on 7th and 8th June 2018 in San Francisco, CA. ... policy influencers as well as several distinguished CEOs, board directors and government officials from ...
(Date:10/11/2017)... Georgia (PRWEB) , ... October 11, 2017 , ... Disappearing ... taking the lives of over 5.5 million people each year. Especially those living in ... greenovative startup Treepex - based in one of the most pollution-affected countries globally - ...
(Date:10/10/2017)... Angeles, CA (PRWEB) , ... ... ... Inc., a development-stage cancer-focused pharmaceutical company advancing targeted antibody-drug conjugate (ADC) therapeutics, ... uses of targeted HPLN (Hybrid Polymerized Liposomal Nanoparticle), a technology developed in ...
Breaking Biology Technology:
Cached News: